GHS Classification Result

Chemical Name：Isodecanol
CAS：25339-17-7

Result：
ID: 1-257-1）
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid
5 Gases under pressure Not applicable - - - - Liquid
6 Flammable liquids Not classified - - - - Since the flash point by ICSC(1999) is 104degC(open type), it was classified into Not classified.
7 Flammable solids Not applicable - - - - Liquid
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition point 266degC (ICSC,1999)).
10 Pyrophoric solids Not applicable - - - - Liquid
11 Self-heating substances and mixtures Classification not possible - - - - The test method suitable for liquid substances is not established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Although it is an organic compound including oxygen, not fluorine and chlorine, this oxygen has not chemically bound to any elements other than carbon and hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Classification not possible due to lack of data

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - The lower and latest data of 4,720 mg/kg among LD50 value 4,720 mg/kg (Patty (5th, 2001)) and 9,800 mg/kg (Patty (5th, 2001)) of the oral administration test employing a rat is adopted as LD50 value. Although this LD50 value corresponded to the U.N. GHS acute toxicity Category 5, it fell under unadopted category in Japan and was classified into "Not classified".
1 Acute toxicity （Dermal） Not classified - - - - It was classified into "Not classified" from LD50 value >2,600 mg/kg (Patty (5th, 2001)), and >3.56 mL/kg (2,937 mg/kg) (Patty (5th, 2001)) of the dermal administration test employing a rabbit.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Saturated vapor pressure level of this substance (20degC)is 14.8 ppm (0.096 mg/L). Since there was no mortality with 95 ppm in the 6-hour inhalation exposure test employing rats, mice, and guinea pig (Patty (5th, 2001)), the mist standard is applied. Since the 4-hour equivalent is 0.93 mg/L, LC50 value is presumed to be >0.93 mg/L, however, the classification cannot be specified, and classification is not possible.
2 Skin corrosion/irritation Classification not possible - - - - Although there are descriptions, "Moderately irritating" (Patty (5th, 2001)) and "Severely irritating" (Patty (5th, 2001)) in the 24 hour skin irritation test with rabbits in HSDB (2006)), classification is not possible, because they were both tested under severer conditions then 4 hours.
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Although there is a description of "severe eye irritant" (Patty (5th, 2001)) in the eye irritation test employing rabbits, there is a description of "Draize score is 28 after 24 hours and it recovers in seven days." when primary literature (Am.Ind.Hyg.Assoc.J.34 (1974)) was investigated. As mentioned above, it was classified into Category 2.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - Although it has been described as "not sensitizing" in the Draize test employing guinea pig (IUCLID (2000)), classification is not possible because of the source of information of List2 and no other data.
5 Germ cell mutagenicity Classification not possible - - - - Although there is a description of "negative" (IUCLID (2000), BUA 149 (1996)) in the body cell in vitro mutagenicity test (chromosome aberration test employing CHL V79 cell (OECD TG473, GLP)), since there is no data of the in vivo examination, classification is not possible.
6 Carcinogenicity Classification not possible - - - - Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible.
7 Reproductive toxicity Classification not possible - - - - Although there is a description as follows in the oral administration study using pregnant female rats, "Weight decrease of uteruses and fetuses and delayed ossification and deformation in fetuses were observed at the dose level (1,580mg/kg) where mother animals' nasal drip, salivation and degradation of the nervous system central nervous system were observed" (Patty (5th, 2001)), there is a possibility that they were caused by the secondary effect of mother animals' general toxicity, because there are case examples of death with 1,580mg/kg. Although it was described that the fetal toxicity mentioned-above was not expressed with 790mg/kg with which toxicity is not observed in mother animals (Food Chem. Toxicol. 35 (1997)), classification is not possible, because whether or not fetal toxicity is expressed at the dose level where slight effects are observed in mother animals cannot be confirmed and because the possibility that symptoms found in fetuses with 1,580mg/kg were the result of secondary effects of mother animals' general toxicity cannot be denied.
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation） Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since there are descriptions that "severe irritation to the nose, throat, and airway" (Patty (5th, 2001)), and that "an airway is stimulated. Short-term exposure may cause central nervous system depressions" (ICSC (1999)), it was taken as Category 3 (Respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Although there is a description of "orchiatrophy, liver enlargement, liver peroxisome induction, and hypolipaemia were not seen." in the test where 158 mg/kg was administered orally to rats for two weeks (90 days corresponding value: 26 mg/kg), (Patty (5th, 2001)), since there are no test data at higher dose and for a long period of time, classification is not possible. In addition, although BUA 149 (1996) has described that "sign of the hepatotoxic effect" was seen at 1,580 mg/kg, it is the signs out of the range of the guidance value of Category 2.
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 48 hours EC50=3.5mg/L of the crustacea (Daphnia magna) (Environmental Agency eco-toxicity tests of chemicals (1999)).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since acute toxicity was Category 2 and there were no suitable data about rapid degradability, it was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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