GHS Classification Result

Chemical Name：Decan-1-ol
CAS：112-30-1

Result：
ID: 1-257-2）
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid
5 Gases under pressure Not applicable - - - - Liquid
6 Flammable liquids Not classified - - - - Since the flash point by ICSC(2005) is 108degC(closed type), it was classified into Not classified.
7 Flammable solids Not applicable - - - - Liquid
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition point 255degC (ICSC.2005)).
10 Pyrophoric solids Not applicable - - - - Liquid
11 Self-heating substances and mixtures Classification not possible - - - - The test method suitable for liquid substances is not established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Although it is an organic compound including oxygen, not fluorine and chlorine, this oxygen has not chemically bound to any elements other than carbon and hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Classification not possible due to lack of data

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Although the lower value of 4,720 mg/kg corresponded to the U.N. GHS acute toxicity Category 5 from LD50 value 4,720 mg/kg (6th volume (2008) of MOE risk assessment) and 12,800 mg/kg (IUCLID (2000)) of the oral administration test employing a rat, it fell under unadopted category in Japan and was classified into "Not classified".
1 Acute toxicity （Dermal） Not classified - - - - Although LD50 value 3,560 mg/kg of the dermal administration test employing a rabbit (IUCLID (2000)) corresponded to the U.N. GHS acute toxicity Category 5 at home, it fell under unadopted category in Japan and was classified into "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Dusts and mists） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Saturated vapor pressure level of this substance (20degC)is 0.06 mg/L. Since LC50 value with 4 mg/L of the 2-hour inhalation exposure test employing mice (the 6th volume (2008) of the MOE Risk Assessment, IUCLID (2000)) is larger than saturated vapor pressure level, the mist standard is applied. Since 4-hour equivalent LC50 value is 2 mg/L, it was classified into Category 4.
2 Skin corrosion/irritation Classification not possible - - - - For animals, although "irritating" has been described in a 24-hour skin irritation test with rabbits (IUCLID (2000)), it cannot be employed because of being under condition of severer than 4 hours. For humans, although "irritating" has been described in the skin irritation test (IUCLID (2000)), it cannot be adopted because of a three-day repeated dose toxicity test. Therefore, classification is not possible because of inadequate data.
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		There is a description of "corneal injury is caused" (Patty (5th, 2001)) in the eye irritation test employing rabbits. Moreover, in HSDB (2006), there is a description of "The degree of injury to the eye is level 2 in 10 levels (Level 10 shows the strongest damage.)" in the test employing rabbits. As mentioned above, it was classified into Category 2.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - For humans, although there is a description of "not sensitizing" in the Maximization tests (IUCLID (2000)), classification is not possible because of the sources of information of List2 and no other data.
5 Germ cell mutagenicity Classification not possible - - - - There is a description that "abnormalities were observed in 3.4% of cell" by a body cell in vivo mutagenicity test (mutagenicity test employing rats bone marrow cell) (IUCLID (2000)), however, the conclusion was not specified and there was no statement about decision in primary literature (Tsitol.Genet.22 (1988)) when investigated. Moreover, since there is a description that an in vitro mutagenicity test (reverse mutation tests employing a Salmonella typhimurium) was "negative" (IUCLID (2000)), classification is not possible.
6 Carcinogenicity Classification not possible - - - - Since no evaluation by major international evaluation agencies is made, classification is not possible. In addition, there is a description that "the promoter activity of this article is weak to moderate in the 60-week dermal administration test of female mice in which 7,12-Dimethylbenz[a]anthracene was an initiator" (Patty (5th, 2001)), and IUCLID (2000) is evaluating this data that "skin cancers is observed and it is a promoter of cutaneous papillomatosis".
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is a description as follows in the inhalation exposure test with saturated steam applied to female rats of 1-19 day pregnancy, "No administration related effect was observed on the body weight of mother rats, resorption, fetal animals' body weight, gender ratio, outer surface, bone structure, internal organ, etc.,"(MOE Risk Assessment Vol.6 (2008), JECFA (2006), Patty (5th, 2001), IUCLID (2000), HSDB (2006)). On the other hand, there is a description as follows in the oral administration test of a 40% solution to female rats of 1-15 day pregnancy, "Fetal toxicity has been reported" (JECFA (2006), Patty (5th, 2001) and, when the primary literature (SOV. J. Dev. Biol. 22 (1990)) was reviewed, although there was a description as follows, "Hydrocephalus, hydronephrosis and suppression of ossification are included in the development disorder." it was classified in Class 2, because there was no description about mother animals.
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation） Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since there is a description that "Oral intake causes a stomachache, the feeling of red heat of a throat or a chest, vomits, and nausea, and inhalation causes a cough and a pharynx pain" (MOE Risk Assessment / the 6th volume (2008)) and "Respiratory tract irritations" (HSDB (2006)), it classified into Category 3 (Respiratory tract irritation). In addition, there is description "a central nervous systems may be affected in a high-concentration case" (the 6th volume (2008) of MOE risk assessment), however, it is not adopted because concentration is unknown in the reference from ICSC1490 (2005).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - There is a description that, in the two-months inhalation exposure test employing rats and rabbits, "reduction in serum cholinesterase activity in the group with 200 mg/m3 or more and focal irritation in the group with 600 mg/m3 " were seen."(MOE Risk Assessment, Volume (2008), HSDB (2006)) and although both are within the range of the guidance value of Category 2, classification is not possible due to insufficient data.
10 Aspiration hazard Category 1 Danger H304: May be fatal if swallowed and enters airways P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331: Do NOT induce vomiting.
P405: Store locked up.
P501: Dispose of contents/container to ... 		"After aspiration of 0.2 mL of the substance, nine out of the nine rats died" (Patty (5th, 2001)) and "it is harmful if inhaled, and it shows solubility behavior like the hydrocarbons in a small quantity (0.2 mL)" (HSDB (2006)). Moreover, the kinematic viscosity at 20degC is calculated to be 16.6 mm2/s (20degC), and at 40degC, the viscosity is expected to be 20.5 mm2/s or less. Therefore, it is classified into Category 1.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 72 hours EC50=0.56mg/L of the algae (Pseudokirchneriella subcapitata) (MOE eco-toxicity tests of chemicals (1999)).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since acute toxicity was Category 1, there were no data about rapid degradability and there were bio-accumulation (LogKow = 4.57 (PHYSPROP Database (2008))), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

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Model SDS by MHLW

 MHLW Website （in Japanese Only）

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