GHS Classification Result

Chemical Name：3,7,11,15-Tetramethylhexadec-1-en-3-ol
CAS：505-32-8

Result：
ID: 1-269
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid
5 Gases under pressure Not applicable - - - - Liquid
6 Flammable liquids Not classified - - - - Since the flash point by IUCLID(2000) is 135degC(closed type), it was classified into Not classified.
7 Flammable solids Not applicable - - - - Liquid
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Classification not possible - - - - Classification not possible due to lack of data
10 Pyrophoric solids Not applicable - - - - Liquid
11 Self-heating substances and mixtures Classification not possible - - - - The test method suitable for liquid substances is not established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Although it is an organic compound including oxygen, not fluorine and chlorine, this oxygen has not chemically bound to any elements other than carbon and hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Classification not possible due to lack of data

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - It was classified into "Not classified" from >12,000 mg/kg which is the latest data among LD50 value >8,000 mg/kg, > 5,400 mg/kg, and >12,000 mg/kg (SIDS (2006)) of the oral administration test employing a rat.
1 Acute toxicity （Dermal） Not classified - - - - From a description of LD50 value of >5,000 mg/kg (SIDS (2006)) in the dermal administration test employing rabbits, it was classified into "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Saturated vapor pressure level at 20degCis 0.03 ppm. Since it is written in SIDS (2006) that NOEC of the 8-hour inhalation exposure test employing guinea pig is 0.3 mg/m3 (equivalent 0.025 ppm), it is classified according to the gas standard. Therefore, since 4-hour equivalent LC50 value is >0.025 ppm, and the classification cannot be specified, classification is not possible.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Classification not possible - - - - Although it has been described that moderate to severe irritation (SIDS (2006)) was determined in the skin irritation test with rabbits, the result was obtained by 24-hour dose. Moreover, although it has been described that no serious skin reaction (SIDS (2006)) was not triggered in the 48-hour dose study in human (27 volunteers), the tested concentration was 10%. As mentioned above, classification is not possible with no appropriate data.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		There is a description that although mild redness and turbidity are seen 1 hour 24-hour after medication and they recovers in eight days in the eye irritation test employing rabbits and it is "slightly irritating", the dose is 0.05 mL which is smaller compared with current 0.1 mL of OECD TG 405 (SIDS (2006)). Although the recovery required 7 days or more, the symptom was thought to be mild and it was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Not classified - - - - Although the result of the Maximization tests employing 30 guinea pig (OECD TG 406, GLP) was ambiguous, it was classified into "Not classified" since it was estimated as not sensitizing (SIDS (2006)) and was also not sensitizing (SIDS (2006)) in the Maximization test in 27 humans.
5 Germ cell mutagenicity Not classified - - - - Since it was negative (SIDS (2004)) in the body cell in vivo mutagenicity test (micronucleus test employing the bone marrow cell of the mouse (OECD TG 474, GLP)), it was classified into "Not classified".
6 Carcinogenicity Classification not possible - - - - Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In the first generation reproductive toxicity study (OECD TG 415, GLP) via oral administration for 98 days using rats increase in the pre-mating time, decrease in fertilizing capacities, conception rates and the number of birth were observed and decrease of the body weight during the nursing period was observed among mother animals with 1,000mg/kg (recovering after the completion of the nursing period) (SIDS (2006)). At the same time, based on the description that decrease in the number of birth and body weight among baby animals during the nursing period was found (SIDS (2006)) as the fetal toxicity effect with 1,000mg/kg in the first generation reproductive toxicity study (OECD TG 415, GLP) via oral administration for 10 weeks using rats, it was classified in Category 2.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - It has been described that although initial escape attempts were observed in the inhalation exposure test employing rats, there was no abnormality in the dissection during 8 hours exposure and after exposure (SIDS (2006)). Since the test concentration is unknown and there is no other data, classification is not possible.
9 Specific target organ toxicity - Repeated exposure Not classified - - - - As a result of testing by the dosage out of the range of the guidance value of Category 2 in 28-day oral administration test in rats (OECD TG 407,GLP), effects were found only on increase in liver, kidney, and lien weight (SIDS (2006)), therefore, it was classified into "Not classified".
10 Aspiration hazard Classification not possible - - - - Classification is not possible because there is no data. In addition, the kinematic viscosity at 20degC is 86.03 mm2/s.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 48 hours EC50=0.13mg/L of the crustacea (Daphnia magna) (SIDS (2006)).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Although acute toxicity was Category 1 and there were rapid degradability (the decomposition by BOD: >60% (SIDS (2006))), since there were bio-accumulation (LogKow = 8.23 (PHYSIPROP Database (2008))), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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