NITE - Chemical Management Field

GHS Classification Result

Chemical Name：tert-Dodecanethiol
CAS：25103-58-6

Result：


ID:	1-274
Classifier:	Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified:	FY2008
Reference Manual:	GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Liquid
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Liquid
5	Gases under pressure	Not applicable	-	-	-	-	Liquid
6	Flammable liquids	Category 4	-	Warning	H227: Combustible liquid	P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ...	Although the flash point (closed type) by IUCLID(2000) includes 82degC and 95degC, 82degC was adopted and it was classified into Category 4.
7	Flammable solids	Not applicable	-	-	-	-	Liquid
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9	Pyrophoric liquids	Not classified	-	-	-	-	Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition point 350degC (Merck KGaA data from March 2009)).
10	Pyrophoric solids	Not applicable	-	-	-	-	Liquid
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	The test method suitable for liquid substances is not established.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13	Oxidizing liquids	Not applicable	-	-	-	-	It is an organic compound not containing oxygen, fluorine or chlorine.
14	Oxidizing solids	Not applicable	-	-	-	-	Liquid
15	Organic peroxides	Not applicable	-	-	-	-	The organic compound not including peroxy group in molecule.
16	Corrosive to metals	Classification not possible	-	-	-	-	Classification not possible due to lack of data

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	From a description of LD50 value of 7,600 mg/kg (Patty (5th, 2001)) in the oral administration test employing rats, it was classified into "Not classified".
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	From a description of LD50 value of >10,200 mg/kg (Patty (5th, 2001)) and 12,600 mg/kg (IUCLID (2000)) in the dermal administration test employing rabbits, it was classified into "Not classified".
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	Classification not possible due to lack of data
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	Since it is written that there was no mortality with 2.1 mg/L in 4-hour inhalation exposure test employing rats (Patty (5th, 2001)), LC50 value is considered to be >2.1 mg/L. When applying the dust standard from saturated vapor pressure level of this substance (20degC)with 0.27 mg/L, classification cannot be specified, classification is not possible.
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	Although it has been described that "severe irritation" (Patty (5th, 2001)) was observed in the skin irritation test with rabbits, the primary literature was also not available because of unknown test time. The results of "moderate" and "slightly irritating" in the skin irritation test with rabbits have been described in IUCLID (2000). The test with evaluation of "moderate" (IUCLID (2000)) cannot be employed since it is a 24-hour test with unknown degree of irritation in 4 hours. Moreover, although the test with evaluation of "slightly irritating" (IUCLID (2000)) is a Draize test and describes PII=1.0, the concentration of test substance is unknown. Since any of them have unknown details of the test conditions and different evaluation results, classification is not possible.
3	Serious eye damage/eye irritation	Category 2B	-	Warning	H320: Causes eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling.	There is description of "Although iritis and mild conjunctivitis are caused after drop to the eye, it recovers in 24 hours."(Patty (5th, 2001)) in the eye irritation test employing rabbits, and IUCLID (2000) evaluates the two cases of the eye irritation test using rabbits as "mild" and "slightly irritating", respectively. As mentioned above, it was classified into Category 2B.
4	Respiratory sensitization	Classification not possible	-	-	-	-	Classification is not possible since there is no data.
4	Skin sensitization	Classification not possible	-	-	-	-	For animals, while there is a description of "not sensitizing (IUCLID (2000))," it has also been described that "the substance can be regarded as sensitizing" (IUCLID (2000)) in the Buehler test with guinea pig. About humans, it has been described that "allergic dermatitis was observed in workers exposed" (IUCLID (2000)). Classification is not possible since any information are from List2, and since the evaluation result is different between humans and animals
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	Although there are descriptions of "negative" in the in vitro mutagenicity test (mouse lymphoma test) (IUCLID (2000)) and "negative" in the in vitro genotoxicity test (SCE test employing a CHO cell) (IUCLID (2000)), classification is not possible because there is no data of in vivo examination.
6	Carcinogenicity	Classification not possible	-	-	-	-	Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible.
7	Reproductive toxicity	Classification not possible	-	-	-	-	There is a description as follows, "NOAEL for teratogenicity is the maximum dose level of 88.6ppm (0.37mg/L)" (IUCLID (2000)) in the 14 day inhalation exposure test using rats. In addition, there is a description as follows also in the 10 day inhalation exposure test (GLP) using mice, "NOAEL for teratogenicity is 88.6ppm (0.37mg/L)" (IUCLID (2000)). Acquisition of primary literature, however, is difficult and details are unknown. Moreover, since data for the effect on reproductive functions are not available, classification is not possible.
8	Specific target organ toxicity - Single exposure	Category 2 (central nervous system)		Warning	H371: May cause damage to organs (central nervous system)	P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ...	It has been described that as clinical symptoms, locomotor activity control, piloerection, and remarkable weight reduction were seen but, in necropsy, pathological change was not observed "in the oral administration test employing rats (Patty (5th, 2001)). Moreover, there is a description of "spasm and hyperventilation were seen 3 minutes after exposure, and hemorrhagic rhinitis and salivation were observed" within the range of the guidance value of Category 2 in 4 hours inhalation exposure test employing rats (Patty (5th, 2001)). As mentioned above, it was classified into Category 2 (central nervous systems).
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (liver)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	There is a description of "The mild kidney tubules denaturation relevant to hydrocarbon nephropathy, etc., discovered in male rats" at the exposures within the range of the guidance value of Category 2 in 28 days inhalation exposure test employing rats (IUCLID (2000)). Moreover, there is a description of "The liver weight increased depending on the exposures, and the liver enlargement, fading, and hepatic cell hypertrophy were observed in both of male and female" at the exposures within the range of the guidance value of Category 2 in 28 days inhalation exposure test employing mice. (IUCLID (2000))Since the kidney indications can be considered to be specific effects male rats, it is not adopted. As mentioned above, it was classified into Category 2 (liver).
10	Aspiration hazard	Classification not possible	-	-	-	-	Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 48 hours EC50=0.075mg/L of the crustacea (Daphnia magna) (Environmental Agency eco-toxicity tests of chemicals (1999)).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since acute toxicity was Category 1 and there were no data about rapid degradability, it was classified into Category 1.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）