GHS Classification Result

Chemical Name:1,3,5-Trichlorobenzene
CAS:108-70-3

Result:
ID: 1-290-3)
Classifier: Ministry of Economy, Trade and Industry (METI), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid
5 Gases under pressure Not applicable - - - - Solid
6 Flammable liquids Not applicable - - - - Solid
7 Flammable solids Not classified - - - - Since it was classified into Class 6.1 and PG III in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.2321 (HSDB (2008)), it was classified into Not classified.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid
10 Pyrophoric solids Not classified - - - - Since it was classified into Class 6.1 an PG III in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.2321 (HSDB (2008)), it was classified into Not classified.
11 Self-heating substances and mixtures Classification not possible - - - - The test method applicable for substances becoming liquid or gas at 140degC of test temperature has not been established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Solid
14 Oxidizing solids Not applicable - - - - Although it is an organic compound including chlorine, not oxygen and fluorine, chlorine has bound only to carbon.
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
As LD50 value of the oral administration test employing a rat, there is a description of 1,800 mg/kg, 2,100 mg/kg, 2,490 mg/kg, and 2,800 mg/kg in DFGOT vol.3 (1992), and a description of 800 mg/kg 4th volume (2005) of the MOE risk assessment. Since there existed two or more data which corresponded to Category 4 and "Not classified", high-risk category was adopted and considered it as Category 4.
1 Acute toxicity (Dermal) Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - It is written that there was no mortality in the test in which 1-hour inhalation exposure of the saturated steam was carried out to rats (DFGOT vol.3 (1992)). Although a vapor standard is applied from saturated vapor pressure level (25degC) with 2.3 mg/L, 4-hour equivalent LC50 value is presumed to be >1.15 mg/L, classification is not possible since classification cannot be specified, .
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - It is written that lethal concentration of the inhalation exposure test employing rats (1 hour) is >9,300 mg/m3 (the 4th volume (2005) of MOE Risk Assessment). When applying the dust standard from saturated vapor pressure level with 2.3 mg/L at 25degC, 4-hour equivalent LC50 value is presumed to be >2.3 mg/L, however, classification is not possible since classification cannot be specified.
2 Skin corrosion/irritation Not classified - - - - There is a description of a 24 hour batch test with rabbits in DFGOT vol 3 (1992), saying, " Erythema and edema were observed in 6/6 and erythema was observed in 3/6 animals in 72 hours. This substance therefore is mild irritant." and there is a description of a similar batch test using rabbits, saying, "Noteworthy dermal changes that are the special feature of irritation were observed." Although it seemed to correspond to UN GHS Skin irritation Category 3 based on the above-mentioned, it was classified into "Not classified", because Category 3 is not domestically adopted.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
In DFGOT vol.3 (1992), there is a description of "In the test where 100 mg of this substance was instilled into the eyes of a rabbit, mild and temporary redness, conjunctiva dropsy, and eye discharge arose and the recovery took seven days in the rabbit which was not rinsed." and a description of "The irritation to mucosa ranged from mild to moderate " in the test where it was medicated to the eyes of a rabbit. As mentioned above, it was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - Although it has been described that "sensitizing properties were not observed" in the test employing guinea pig (DFGOT vol.3 (1992)), classification is not possible because of no other data.
5 Germ cell mutagenicity Classification not possible - - - - Although there is a description of "slightly positive" by a body cell in vivo mutagenicity test (micronucleus tests which employed mouse erythrocyte) (DFGOT vol.3 (1992)), EU-RAR which is about isomer 1,2,4-trichlorobenzene (2003) described on this test that "a question lingers in the validity of positive finding since the test protocol is not so suitable"On the other hand, there is a description that the in vitro mutagenicity test (chromosome aberration test employing a chinese hamster cells --) and the Ames test employing Salmonella typhimurium and bacillus coli was "negative" (CaPSAR (1993), NTP DB (Access on December 2008), DFGOT vol.3 (1992)). As mentioned above, since there is not enough data for classifying, classification is not possible.
6 Carcinogenicity Classification not possible - - - - Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible.
7 Reproductive toxicity Classification not possible - - - - There is a description as follows, "A significant increase in the liver weight, changes in liver tissues, and decrease in hemoglobin cocentrations and hematocrit values with mother animals were observed in the forced oral administration study with rats of 6-15 day pregnancy. Although disorders were observed in the crystsl lens of fetuses' eyes, changes in the number of fetuses and fetuses' body weight and deformation of bone structure and internal organs were not observed" (MOE Risk Assessment Vol.4 (2005), HSDB (2004)). There is a description as follows, however, about this study, "Since the effect on eyes was not dose dependent, there seems to be no relation between this substance and exposure."(EU-RAR (2003)) In addition, there is a description as follows in the forced oral administration study applied to rats for 6-15 days during pregnancy, "Lesions in the liver and thyroid gland and decrease in hematocrit values and hemoglobin concentrations were observed. Although slight osteogenic changes were observed in fetuses, no serious deformation was observed" (Patty (5th, 2001), DFGOT vol. 3 (1992)). There is no other data and, since the effects on reproductive functions are not known, classification is not possible.
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation) Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
It is indicated that "nerve tremor, entasia, nasal mucus mixed with blood, dacryorrhea, and noisy breathing occur as with nonspecific symptom (piloerection, inactivity, disequilibrium, ataxia, etc.) at a high dose" in the paragraph of the acute toxicity of DFGOT vol.3 (1992) for animals. For humans, it is described as "An airway is irritated and cough and pharynx pain occur as acute symptoms." as effect on humans in MOE Risk Assessment, Volume 4 (2005)). For the animals' data, since the dose was unknown and the classification was not able to be identified, it was not adopted, thus, it was classified into Category 3 (Respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Category 2 (liver, kidney, thyroid, nasal cavity) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver, kidney, thyroid, nasal cavity) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
It has been described that, in the 13-weeks mixed feed administration test employing rats, " the weight increase of liver and kidney in female, increase of hepatic cell capacity and anisokaryosis increase in male and female, follicle reduction in thyroid gland, increase of the height of a follicular cell, colloid density reduction, and mild to moderate denaturation of nephric tubule in kidney" (MOE Risk Assessment, Volume 4 (2005)), CaPSAR (1993), Patty (5th, 2001), DFGOT vol.3 (1992)). There are descriptions of "The increase in the relative weight of liver was seen" in 4 weeks inhalation exposure test employing rats. (CaPSAR (s) (1993)) and of "The squamous metaplasia and hyperplasia of the respiratory nasal airway epithelium were observed" in 13 weeks inhalation exposure test employing rats. (CaPSAR (s) (1993), MOE Risk Assessment, Volume 4 (2005)), DFGOT vol.3 (1992). Since all these symptoms were seen within the range of the guidance value of Category 2, it was classified into Category 2 (liver, kidney, thyroid gland, nasal cavity). In addition, for humans, although there are descriptions of "The woman who had immersed the work clothes in Chlorobenzenes and washed them for a long period of time had experienced the aplastic anemias."(MOE Risk Assessment, Volume 4 (2005)), Patty (5th, 2001) and of "Some worker of 28 workers who was exposed to Trichlorobenzenes complained headache, giddiness, deep sleep, and indigestion" (MOE Risk Assessment, Volume 4 (2005))), the isomer has not been identified and it is unknown whether it is the influence due to this substance, it is not adopted.
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) - - - - - -
11 Hazardous to the aquatic environment (Long-term) - - - - - -


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

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