GHS Classification Result

Chemical Name:1,2,4-Trimethylbenzene
CAS:95-63-6

Result:
ID: 1-296
Classifier: Ministry of Economy, Trade and Industry (METI), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid
5 Gases under pressure Not applicable - - - - Liquid
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Since the flash point by ICSC(2002) is 44degC(closed type), it was classified into Category 3.
7 Flammable solids Not applicable - - - - Liquid
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition point 500degC (Lide,88th,2007)).
10 Pyrophoric solids Not applicable - - - - Liquid
11 Self-heating substances and mixtures Classification not possible - - - - The test method suitable for liquid substances is not established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - It is an organic compound not containing oxygen, fluorine or chlorine.
14 Oxidizing solids Not applicable - - - - Liquid
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Classification not possible due to lack of data

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Although LD50 value 5,000 mg/kg of the oral administration test employing a rat (female) (6th volume (2008) of the MOE risk assessment, RTECS (2008)) corresponded to the U.N. GHS acute toxicity Category 5, it fell under unadopted category in Japan and was classified into "Not classified".
1 Acute toxicity (Dermal) Classification not possible - - - - Since there is no data as this substance, classification is not possible. In addition, as to Solvesso 100 which contains 29.4% of this substance, LD50 value of the dermal administration test employing rabbits (GLP) is >3,160 mg/kg (IUCLID (2000)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity (Inhalation: Dusts and mists) Not classified - - - - Saturated vapor pressure level of this substance at 25degC is 14.60 mg/L (2,969 ppm). Since LC50 value of the 4-hour inhalation exposure test employing rats is 18 mg/L (the 6th volume (2008) of the MOE Risk Assessment, RTECS (2008)), it was classified into "Not classified" by applying the mist standard. EU classification is Xn; R20 (EU-Annex I).
2 Skin corrosion/irritation Classification not possible - - - - Although it has been described that liquid Trimethylbenzene has a primary skin irritation (ACGIH (7th, 2001)), classification is not possible because of unknown degree of irritation. It can be classified as Xi in the EU classification; R36/ 37/ 38 (EU-Annex I). In addition, the paragraph of the effects of short term exposure in ICSC (2002) has a description that "the skin is stimulated."
3 Serious eye damage/eye irritation Classification not possible - - - - There are descriptions that Trimethylbenzene has eye irritation (ACGIH (7th, 2001)) and of "slightly irritating" (IUCLID (2000)) in the test employing rats. Since the irritation level is unknown in the description of ACGIH (7th, 2001), IUCLID (2000) is the information source of List2, and OECD TG standard and GLP are unknown, classification is not possible. EU classification is Xi; R36/37/38 (EU-Annex I). In addition, the paragraph of the effects of short durations exposures of ICSC (2002) has described as "The eye is irritated."
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - Although there is a description of "no sensitizing potential" in the Maximization test employing guinea pig (IUCLID (2000)), classification is not possible because of the source of information of List.2 and unknown OECD TG conformity and GLP.
5 Germ cell mutagenicity Not classified - - - - Although there is a description of "positive finding only at a high dose" (Patty (5th, 2001)) in the body cell in vivo genotoxicity test (SCE test employing the mouse bone marrow cell), since the body cell in vivo mutagenicity test (micronucleus test using the mouse bone marrow cell) was "negative" (Patty (5th, 2001)), it was classified into "Not classified".
6 Carcinogenicity Classification not possible - - - - Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible.
7 Reproductive toxicity Classification not possible - - - - There is a report of "significantly lower fetal weights at doses at which there was significantly decreased weight gain in mother animals" (MOE Risk Assessment (2008)) in a repeated inhalation exposure test in rats. When we checked the primary literature (Food Chem. Toxicol. 43 (2005)), it was reported that "there were no significant changes in the numbers of implantations and live fetuses, loss of postimplantation embryos and absorption, and there were no significant deformations of organs or the skeleton in the fetuses, and significantly lower fetal weights at a higher side of doses were 5% and 11-12%." Moreover, since there is no data concerning reproductive capacity and fertility in the parents, classification is not possible.
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation, Narcotic effects) Warning H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects)
H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects)
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
About humans, while there is a description that "the CNS central nervous system and irritation were not foreseen in a low-dose" (Patty (5th, 2001)), there is a description of "respiratory tract irritation" (ACGIH (7th, 2001)). As for animals, there was also a description of "loss of righting reflex" in the inhalation exposure test employing mice (Patty (5th, 2001)), therefore, it classified into Category 3 (Respiratory tract irritation, Narcotic effects). The EU classification is Xi; R36/37/38 (EU-Annex I).
9 Specific target organ toxicity - Repeated exposure Category 2 (central nervous system, lung) Warning H373: May cause damage to organs through prolonged or repeated exposure (central nervous system, lung) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
For humans, it is reported that "in a survey of workers using a solvent containing Trimethylbenzene isomers adulterated with Benzene, symptoms of the central nervous system, symptoms of the central nervous system, asthmatoid bronchitis and anemia can be seen, but for anemia the effects of Benzene cannot be ignored" (ACGIH (7th, 2001), (MOE Risk Assessment, vol. 6 (2008)). However, this solvent was a mixture containing 50% of the substance under consideration and 30% of isomers 1, 3, and 5, so this report was not used. For animals, there are reports that "reversible tubular hyaline droplet degeneration were observed in the kidney in males, but no effects in females" (Ministry of Health, Labor and Welfare Report (Access on September 2008)) in a 28-day repeated oral toxicity test in rats (Guidelines for the 28-Day Repeat Dose Toxicity Test of Chemicals (Japan), GLP), and that "irreversible impairment in motor coordination, significantly increased incidence of lung damage and reduction of erythrocyte count" (MOE Risk Assessment, vol. 6 (2008)) were observed in a 3-month inhalation exposure test in male rats. Effects on laboratory animals seen in the central nervous system, lungs and blood system are all within the range of guidance values for Category 2, but there are no other findings on the blood system, so these reports are not used. The kidney symptoms are considered to be effects specific for male rats, and are outside the range of guidance values for Category 2. For the reasons stated above, it was classified as Category 2 (central nervous system, lungs).
10 Aspiration hazard Category 1 Danger H304: May be fatal if swallowed and enters airways P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331: Do NOT induce vomiting.
P405: Store locked up.
P501: Dispose of contents/container to ...
ICSC (2002) shows that "oral administration of this liquid may cause chemical pneumonitis if inhaled into the lungs." Furthermore, the kinematic viscosity estimated from the viscosity of 1.00 cP (Chemical Engineers' Handbook) at 25degC and the density 0.872 g/cm3 at 20degC was about 1.15 mm2/s. Since the level at 40degC is expected to be <1.14 mm2/s which is lower than the guidance value of 20.5 mm2/s, it was classified into Category 1.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 2 from 48 hours EC50=6.14mg/L of the crustacea (Daphnia magna) (IUCLID (2000)).
11 Hazardous to the aquatic environment (Long-term) Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since acute toxicity was Category 2 and there were no rapid degradability (28 days decomposition rate=4-18%(OECD TG301C) (Existing Chemical Safety Inspections Data (1977))), it was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


To GHS Information