GHS Classification Result

Chemical Name:Nonan-1-ol
CAS:143-08-8

Result:
ID: 1-319
Classifier: Ministry of Economy, Trade and Industry (METI), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid
5 Gases under pressure Not applicable - - - - Liquid
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Since the flash point by NFPA(13th,2002) is 74degC, it was classified into Category 4.
7 Flammable solids Not applicable - - - - Liquid
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition point 260degC (Lide,88th,2007)).
10 Pyrophoric solids Not applicable - - - - Liquid
11 Self-heating substances and mixtures Classification not possible - - - - The test method suitable for liquid substances is not established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Although it is an organic compound including oxygen, not fluorine and chlorine, this oxygen has not chemically bound to any elements other than carbon and hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Classification not possible due to lack of data

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Although lower value of 3,560 mg/kg corresponded to the U.N. GHS acute toxicity Category 5 from LD50 value 3,560 mg/kg of the oral administration test employing a rat and 12,000 mg/kg (the MOE risk assessment / 6th volume (2008), HSDB (2006)) At home, it fell under unadopted category in Japan and was classified into "Not classified".
1 Acute toxicity (Dermal) Not classified - - - - Although LD50 value 2,960 mg/kg of the dermal administration test employing a rabbit (Patty (5th, 2001)) corresponded to the U.N. GHS acute toxicity Category 5, it fell under unadopted category in Japan and was classified into "Not classified".
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity (Inhalation: Dusts and mists) Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
Saturated vapor pressure level at 25degCis 0.18 mg/L.. Since LC50 value of 2-hour inhalation exposure test employing mice is 5,500 mg/m3 (the 6th volume (2008) of the MOE Risk Assessment, Patty (5th, 2001)), the mist standard is applied. 4-hour equivalent LC50 value is 2.75 mg/L, and it was classified into Category 4 by applying the mist standard.
2 Skin corrosion/irritation Classification not possible - - - - Although there is a description, "The irritation scores in undeluted liquid were 5.8/8.0 and they recovered in 10-14 days,"(HSDB (2006)) as a result of the 24 hour skin irritation test with rabbits classification is not possible, due to insufficiency of data. Incidentally, although there is a description, " Vaseline containing 2% of this substance did not cause irritation nor sensitivity in an volunteered experiment,"(MOE Risk Assessment, Vol. 6 (2008), Patty (5th, 2001)), it cannot be adopted, because it is not a datum with this substance undeluted.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
From the descriptions that "If 1-Nonanol eye irritation score is evaluated at the EU standard, it is thought to be eye irritant" (Patty (5th, 2001)) and that "The average irritation score of the non-diluted solution is 33.3/110 in 24-hours eye irritation test employing a rabbit and the symptom was slight actinic erythema, large amounts of copious discharge, and unrefined corneas" (HSDB (2006)), it was classified into Category 2A.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - Although it has been described that "vaseline which contains 2% of the substance did not show an irritation or sensitization to skin in a volunteer test" (the 6th volume of MOE Risk Assessment (2008)), or that "Nonanol (2% Petrolatum solution) is not a skin sensitizing substance to humans" (Patty (5th, 2001)), classification is not possible since they are inadequate for generalizing and there is no animal data in addition.
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data
6 Carcinogenicity Classification not possible - - - - Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible.
7 Reproductive toxicity Classification not possible - - - - It is described as follows in the 7 hour inhalation exposure test using female rats of 1-19 day pregnancy, "No effect related with the administration on mother rats' body weight, resorption, fetal animals' body weight, gender ratio, bone structure, internal organs, etc."(MOE Risk Assessment Vol. 6 (2008), Patty (5th, 2001)). In addition, there is a description as follows in the oral administration study using female rats of 1-15 day pregnancy, " Delayed growth of fetuses including embryos/fetal toxicity and delayed ossification has been reported" (Patty (5th, 2001)), and when the primary literature (Sov. J. Dev. Biol. 22 (1990)) was reviewed, symptoms were those of the intake result of some alcohol from Methanol to Decanol and the type of symptoms expressed with Nonanol was unknown, although there was a description as follows, " No teratogenicity is observed with fetuses but growth abnormalities of internal organs and bone structure are caused." Based on the above-mentioned, classification is not possible.
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation) Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
In the results of acute test against animals, from a description of "It has irritation to the skin, eye, and respiratory tract."(Patty (5th, 2001)), it was classified into Category 3 (Respiratory tract irritation). Although there is a description of "Weight reduction, increasing weakness, gum of eyelid, and sign of atrophy occur and, as a result of autopsy, bleeding of lungs, discoloration of liver, and gastroenteritis were observed"as a result of the oral administration test employing rats (HSDB (2006)), the discovered dose is unknown.
9 Specific target organ toxicity - Repeated exposure Category 2 (eye) Warning H373: May cause damage to organs through prolonged or repeated exposure (eye) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In a 6-month inhalation exposure test with rabbits, it was reported that "changes were observed in the fine structure of the photoreceptor cells and the Muller fibers of the retina" (MOE Risk Assessment, vol. 6 (2008), HSDB (2006)). These were within the range of guidance values for Category 2, so it was classified as Category 2 (eye).
10 Aspiration hazard Classification not possible - - - - "Ten out of the ten rats died by aspiration, and the deaths were caused immediately by respiratory arrest" (Patty (5th, 2001)). Moreover, although the kinematic viscosity at 20degC is calculated to be 14.13mm2/s (HSDB (2006)) and the viscosity at 40degC is expected to be 20.5mm2/s or less, the classification is not possible since the substance is not hydrocarbon. Although it falls into the U.N. GHS Category 2, the classification is not possible in Japan since it is categorized into "Not applicable."

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 2 from 72 hours EC50=2.2mg/L of the algae (Pseudokirchneriella subcapitata) (Environmental Agency eco-toxicity tests of chemicals (1999)).
11 Hazardous to the aquatic environment (Long-term) Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since acute toxicity was Category 2 and there were no data about rapid degradability, it was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

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Model SDS by MHLW

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