GHS Classification Result

Chemical Name:2-Phenyl-2-[(2-phenylpropan-2-yl)peroxy]propane
CAS:80-43-3

Result:
ID: 1-330
Classifier: Ministry of Economy, Trade and Industry (METI), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Although the peroxide group is included in chemical structure, since the calculation value of oxygen balance was -266 it was classified into Not classified.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid
5 Gases under pressure Not applicable - - - - Solid
6 Flammable liquids Not applicable - - - - Solid
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data
8 Self-reactive substances and mixtures Not applicable - - - - Organic peroxide
9 Pyrophoric liquids Not applicable - - - - Solid
10 Pyrophoric solids Not classified - - - - Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition point 380degC (IUCLID,2000)).
11 Self-heating substances and mixtures Classification not possible - - - - The test method applicable for substances becoming liquid or gas at 140degC of test temperature has not been established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Solid
14 Oxidizing solids Classification not possible - - - - Although it is an organic compound having peroxy group in the molecule, classification is not possible due to lack of data.
15 Organic peroxides Type F Warning H242: Heating may cause a fire P411+P235: Store at temperatures not exceeding ... degC/... degF. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P220: Keep/Store away from clothing/.../combustible materials.
P234: Keep only in original container.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P410: Protect from sunlight.
P420: Store away from other materials.
P501: Dispose of contents/container to ...
It was classified into Class 5.2 in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.3110(ICSC, 1999).
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - From LD50 value >2,000 mg/kg (Health, Labor and Welfare Ministry report (Access on September 2008)) of the acute oral toxicity test (OECD TG 401, GLP) employing a rat, it was classified into "Not classified".
1 Acute toxicity (Dermal) Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Since it is a solid, a dust standard is applied. Since 6-hour LCLo value of rats is >0.09 mg/L (4-hour equivalent >0.14 mg/L) (DFGOT vol.3 (1992), Patty (5th, 2001)), the classification cannot be specified, and classification is not possible.
2 Skin corrosion/irritation Not classified - - - - For patch tests in human, there have been descriptions of "slight" irritation (DFGOT vol.3 (1992)) and "slight" irritation in the patch test to 200 volunteers (Patty (5th, 2001)). Moreover, for rats, although there has been a description of "mild" irritation (Patty (5th, 2001)), and it seems to be equivalent to skin irritation Category 3 in the U.N. GHS, it was classified into "Not classified" with unemployed catergory in the country. It can be classified as Xi in the EU classification; R36/ 38 (EU-Annex I).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
From the description of "mild "eye irritation (DFGOT vol.3 (1992)) of "Mild conjunctivitis was produced in drop of 50% solution."(Patty (5th, 2001)) to rabbits, it was classified into Category 2B. In addition, EU classification is Xi; R36/38 (EU-Annex I).
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Not classified - - - - For humans, it has been described that "it showed a slight irritation not skin sensitization in the patch test to 200 volunteers" (Patty (5th, 2001)). Moreover, there is a description of "no sensitizing potential" in the intracutaneous injection tests employing guinea pig with unknown numbers (Patty (5th, 2001)). Therefore, it was classified into "Not classified".
5 Germ cell mutagenicity Classification not possible - - - - In the in vitro mutagenicity test (the mutagenicity test employing bacteria (OECD TG 471, GLP) and chromosome aberration test employing Chinese hamster culture cells (CHL/IU) (OECD TG 473, GLP)) both are "negative" (Health, Labor and Welfare Ministry reports (Access on September 2008)), classification is not possible because there is no data of in vivo examination.
6 Carcinogenicity Classification not possible - - - - Since no evaluation by major international evaluation agencies is made, classification is not possible. There is no data in the source of information of List1. In addition, HSDB (2002) has a description that "as the comparison of tumor promoting activities of various organic peroxides made by the mouse dermal administration test, this article's activity is in the medium degree."
7 Reproductive toxicity Classification not possible - - - - Classification not possible due to lack of data
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation) Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
There is a description of "The symptoms were observed to tend to recover 1st day after administration and all of them recovered by 6th day." in the oral single administration test employing rats (Health, Labor and Welfare Ministry reports (Access on September 2008)). On the other hand, since there is a description of "It irritates a respiratory tract." in the paragraph of the effects of short term exposure of ICSC (1999), it classified into Category 3 (Respiratory tract irritation). In addition, although there is a description of "Slight inflammation occurred in nasal mucosas within 1 hour after exposure" in dropping test to rabbit's nostril (Patty (5th, 2001)), since it is the effect by non-standard test method, it is not adopted.
9 Specific target organ toxicity - Repeated exposure Category 1 (nasal mucosa) Danger H372: Cause damage to organs through prolonged or repeated exposure (nasal mucosa) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
For humans, "changes in the nasal mucosa" are reported as effects of exposure to this substance in 18 workers (DFGOT vol. 3 (1992), Patty (5th, 2001)). For animals, in 28-day repetition oral administration test using rats (Guideline for 28-Day Repeated oral administration Toxicity Test in Mammalian Species (Chemical Substances Control Law of Japan), GLP), although there is a description of "Hypertrophy and denaturation of hepatic cell" (Health, Labor and Welfare Ministry reports (Access on September 2008)), there is no description about the details of denaturation. From description of "metaplasia of nasal mucosas and loss of cilia (DFGOT vol.3 (1992)), in the repeated inhalation exposure test employing guinea pig, the effect on the nose membrane to the was seen within the range of the guidance value of Category 1 and the effect on liver was seen out of the range of the guidance value of Category 2. As mentioned above, it was classified into Category 1 (nasal mucosas).
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 48 hours EC50=0.26mg/L of the crustacea (Daphnia magna) (Environmental Agency eco-toxicity tests of chemicals (1999)).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since acute toxicity was Category 1 and there were no rapid degradability (not readily degradable, the decomposition by BOD: 0% (standard test method (4 weeks)) (Existing Chemical Safety Inspections Data (1985))), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


To GHS Information