GHS Classification Result

Chemical Name：Furan
CAS：110-00-9

Result：
ID: 1-377
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid
5 Gases under pressure Not applicable - - - - Liquid
6 Flammable liquids Category 1 Danger H224: Extremely flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Since the flash point by Merck(14th,2006) is -35degC(closed type) and the boiling point is 31.36degC, it was classified into Category 1.
7 Flammable solids Not applicable - - - - Liquid
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition point 390degC (Merck KGaA data from March 2009)).
10 Pyrophoric solids Not applicable - - - - Liquid
11 Self-heating substances and mixtures Classification not possible - - - - The test method suitable for liquid substances is not established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Although it is an organic compound including oxygen, not fluorine and chlorine, this oxygen has not chemically bound to any elements other than carbon and hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Classification not possible due to lack of data

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Classification not possible - - - - Classification is not possible because there is no data. In addition, the European Union classification is Xn; R22 (EU-Annex I).
1 Acute toxicity （Dermal） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since it is written that saturated vapor pressure level of this substance (20degC)is 650,000 ppm, and LC50 value in the 1-hour inhalation exposure test employing rats is 3,464 ppm (HSDB (2003)), the gas standard is applied. Since 4-hour LC50 value is 1,732 ppm, it was classified into Category 3.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Classification not possible - - - - Although there is a description, "skin irritation"in the study with guinea pig in HSDB (2003)), this datum is not adopted, because examination of this cited literature (Gig. Saint. 6 (1974)) contained a description, "Since Furan has strong volatility (boiling point: 32degC), irritation was not examined." In addition, there is a description, "primary irritation" in the dermal administration test with rabbits in RTECS (2008), but it is an information source of List3 with details unknown. Therefore, classification is not possible, because data are insufficient. Incidentally, EU division is Xi; R38 (EU-Annex I).
3 Serious eye damage/eye irritation Classification not possible - - - - Although there is a description of "Irritation and burns may be caused by contacting to eyes" (HSFS (2008)), this is the information source of List3 and the details are also unknown. Therefore, since data is insufficient, classification is not possible.
4 Respiratory sensitization Classification not possible - - - - Although it has been described that the influence on the immune system including an allergic reaction was indicated in the inhalation exposure tests employing rats (RTECS (2008)), classification is not possible because of insufficient data.
4 Skin sensitization Classification not possible - - - - Although it has been described that the allergic reactions were observed in the skin painting study employing guinea pig (HSDB (2003)), classification is not possible because of insufficient data.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Although there is a description of the body cell in vivo mutagenicity test (chromosome aberration test employing the mouse bone marrow cell) being positive (IARC 63 (1995), NTP DB (Access on November 2008)), since there was no result of the in vivo genotoxicity testgenotoxicity test employing a germ cell, it was classified into Category 2. In addition, EU classification is Muta. Cat. 3; R68 (EU-Annex I).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since it was estimated as group 2B (IARC 63 (1995)) in IARC, it was classified into Category 2. In addition, there are descriptions of hepatic adenoma and glandular cancer in mice, of hepatic adenoma, cholangiocellular carcinoma, mononuclear cell leukemia in male and female rats, and of hepatocellular carcinoma in male rats (IARC 63 (1995), NTP TR402 (1993), NTP Roc (11th, 2005)). In addition, the European Union classification is Carc.Cat.2; R45 (EU-Annex I).
7 Reproductive toxicity Classification not possible - - - - Classification not possible due to lack of data
8 Specific target organ toxicity - Single exposure Category 2 (central nervous system, digestive system, liver), Category 3 (respiratory tract irritation) Warning H371: May cause damage to organs (central nervous system, digestive system, liver)
H335: May cause respiratory irritation (respiratory tract irritation) 		P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		About humans, HSDB (2003) has a description of "control of a central nervous system, the congestion of a digestive organ, liver damage, low blood pressure, fatigue, and headache" as conditions caused by inhalation exposure. Moreover, "There is Respiratory tract irritation" is described by ICSC (1995). Therefore, it is classified into Category 2 (a central nervous system, an digestive system, liver) and Category 3 (Respiratory tract irritation). In addition, primary literature (NTP Executive Summary: Furan (Draft) (1986)) of HSDB (2003) could not be obtained, and it was not able to check for details.
9 Specific target organ toxicity - Repeated exposure Category 1 (liver, kidney, respiratory system), Category 2 (testis, ovaria) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (liver, kidney, respiratory system)
H373: May cause damage to organs through prolonged or repeated exposure (testis, ovaria) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		There is a description of "liver problems (fault formation, chronic inflammation, biliary fibrosis, vacuolar degeneration and denaturation, necrosis, etc.) and kidney trouble (extension of a nephric tubule, epithelium necrosis)" (NTP TR402 (1993)) in the two years oral administration test (maximum dose: 8 mg/kg) employing mice and rats. Moreover, in the 13-week oral administration test employing rats, there is a description of "Atrophy of testis and ovarian was seen" in 60 mg/kg group (NTP TR402 (1993)). Furthermore, RTECS (2008) has been described as "structural abnormality or functional abnormality of the trachea and bronchus"in the 60 days inhalation exposure test employing rats, and in the 26-week inhalation exposure test using rats, there is a description of "abnormalities to the central nervous system." and when these primary literatures (Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.9 (1967), Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.10 (1968)) were checked, former tracheal or bronchial abnormality had the dosage of guidance value within the range of Category 1 and was the symptom with localized emphysema, however, since the latter central nervous system abnormality was considered to be the symptom in fatality dosage, it was not adopted. As mentioned above, it was classified into Category 1 (liver, the kidney, respiratory system) and Category 2 (testis, ovaria).
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 96 hours LC50=61mg/L of the fish (Fathead Minnows) (AQUIRE (2008)).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Although acute toxicity was Category 3 and there were no rapid degradability (not readily degradable, the decomposition by BOD: 4% (Existing Chemical Safety Inspections Data (1983))), since 31-33 days NOEC(the fish (Fathead Minnows))=8.27mg/L (AQUIRE (2008)) and long-term toxicity was >1mg/L, it was classified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

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Model SDS by MHLW

 MHLW Website （in Japanese Only）

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