GHS Classification Result

Chemical Name：1-Bromopropane
CAS：106-94-5

Result：
ID: 1-384
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid
5 Gases under pressure Not applicable - - - - Liquid
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Since the flash point by ICSC(2004) is -10degC(closed type) and the boiling point is 71.0degC, it was classified into Category 2.
7 Flammable solids Not applicable - - - - Liquid
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition point 490degC (Lide,88th,2007)).
10 Pyrophoric solids Not applicable - - - - Liquid
11 Self-heating substances and mixtures Classification not possible - - - - The test method suitable for liquid substances is not established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - It is an organic compound not containing oxygen, fluorine or chlorine.
14 Oxidizing solids Not applicable - - - - Liquid
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Classification not possible due to lack of data

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - There is a description that LD50 value of the oral administration test employing a rat is >2,000 mg/kg (ACGIH (7th, 2001)). Although LD50 value 3,600 mg/kg was described in RTECS (2008) and corresponded to the U.N. GHS acute toxicity Category 5, at home, it fell under unadopted category in Japan and was classified into "Not classified".
1 Acute toxicity （Dermal） Not classified - - - - Since it was written that there was no example of death even if rats were administered at a dose of up to 2,000 mg/kg in the dermal administration test, and LD50 value was >2,000 mg/kg (ACGIH (7th, 2001)), it was classified into "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Since it is written that saturated vapor pressure level of this substance (20degC)is 132,000 ppm, and LC50 value in the 4-hour inhalation exposure test employing rats is 7,000 ppm (ACGIH (7th, 2001)), it was classified into Category 4 by applying the gas standard.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Classification not possible - - - - Although there is a description of "no skin reaction" in a 24-hour half sealing administration test with rats (ACGIH (7th, 2001)), because of Xi in the EU classification; R36/ 37/ 38 (EU-Annex I) with no other negative test results, classification is not possible with insufficient data.
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		There are descriptions of "Irritation to an eye" as an impact on human in HSDB (2006) and of "An eye is stimulated" in the paragraph of the short-term exposure effects of ICSC (2004). Although the degree is unknown, since it was considered to own irritation, it was classified into Category 2. In addition, EU classification is Xi; R36/37/38 (EU-Annex I).
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - Although it has been described that "no symptom with sensitizing potential was observed" and "there was no data used as a basis of skin sensitization" in the test applying a 25% Paraffin oil solution for 10 days and applying again 12 days later to guinea pig (ACGIH (7th, 2001)), classification is not possible because of inadequate data.
5 Germ cell mutagenicity Not classified - - - - From a description of "negative" (ACGIH (7th, 2001)) in a productive cell in vivo heritable mutagenicity test (dominant lethal test employing a rat) and "negative" (NTP DB (Access on December 2008)) in the body cell in vivo mutagenicity test (micronucleus test using mouse peripheral blood), it was classified into "Not classified".
6 Carcinogenicity Classification not possible - - - - Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is a report of a two-generation inhalation exposure study in rats, in which "a decrease in reproductive function was observed in a group of female rats exposed to 250 ppm or higher. Dose dependency was observed in prolonged estrous cycles and fertilization rate and the number of offspring per litter in F0 and F1" (ACGIH (7th, 2001)), but in this study there are no descriptions concerning the effects on mother animals and it is difficult to obtain primary literature. In addition, there is a report that "the study results show that there must be ovarian dysfunction due to follicular growth inhibition in infertile females" in inhalation exposure test employing rats (HSDB (2006)). There is a report in an inhalation exposure study in 6-19 day pregnant rats that "at the dosage with which decreased weight gain and feed intake were observed in mother animals, dose-dependent retarded ossification was observed. Moreover, there was a significant increase in angulated ribs at high doses" (ACGIH (7th, 2001)). For the reasons stated above, we classified it as Category 2. The EU classifications are Cat. 2; R60 and Cat. 3; R63 (EU-Annex I).
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation, Narcotic effects） Warning H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects)
H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects) 		P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		For animals, ACGIH (7th, 2001) has a description of "Although piloerectionan, hypoactivity, ataxia, and dacryorrhea were discovered, "No macroscopic pathological findings were seen in the rat to which the 1 hour inhalation exposure was applied, in the paragraph of short term exposure of ICSC (2004). Since it was described that a central nervous system may be affected and loss consciousness may occur," it was classified into Category 3 (Respiratory tract irritation, Narcotic effects). In addition, EU classifications is R36/37/38, R67 (EU-Annex I).
9 Specific target organ toxicity - Repeated exposure Category 1 (central nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (central nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In animal case, in the 28-day inhalation exposure test to rats, "defects in central nervous systems, urinary organs, blood systems and lymphatic system" were observed, and in the 13-week inhalation exposure test to rats, "vacuolation in the centrilobular region of the liver" were observed (ACGIH (7th, 2001)). The effects on central nervous system were observed within the limits of guidance value of Category 2, but other effects were seen as the amount exceeding the guidance value of Category 2. In human case, "a 19 year-old male developed numbness in legs and right hand, swallowing and urination difficulty two months after he was occupationally exposed to degreasing solvent containing 95.5% of 1-bromopropane, and it was concluded that those effects were caused by a lesion in central nervous system" (ACGIH (7th, 2001)). Therefore, it was classified into Category 1 (central nervous systems). The EU classification is Xn; R 48/20 (EU-Annex I).
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 96 hours LC50=67.3mg/L of the fish (Fathead Minnows) (HSDB (2006), Aquire (2009))
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Since acute toxicity was Category 3 and there were no data about rapid degradability, it was classified into Category 3.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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