GHS Classification Result

Chemical Name:Perfluoro(octane-1-sulfonic acid)
CAS:1763-23-1

Result:
ID: 1-396
Classifier: Ministry of Economy, Trade and Industry (METI), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid
5 Gases under pressure Not applicable - - - - Solid
6 Flammable liquids Not applicable - - - - Solid
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid
10 Pyrophoric solids Classification not possible - - - - Classification not possible due to lack of data
11 Self-heating substances and mixtures Classification not possible - - - - The test method applicable for substances becoming liquid or gas at 140degC of test temperature has not been established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Solid
14 Oxidizing solids Classification not possible - - - - Although it is an organic compound including oxygen having chemically bound to elements other than carbon and hydrogen, classification is not possible due to lack of data.
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
It was classified into Category 3 from LD50 value 154 mg/kg of oral administration test employing a rat (6th volume (2008) of the MOE Risk Assessment).
1 Acute toxicity (Dermal) Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Classification is not possible because there is no data. In addition, it is written that LC50 value is 5.2 mg/L (4-hour equivalent: 1.3 mg/L) about Potassium perfluorooctane-1-sulfonate (CAS No.2795-39-3) of a related substance (the 6th volume of the MOE Risk Assessment (2008)).
2 Skin corrosion/irritation Not classified - - - - There is a description, "non-irritating" in the section of Animal Toxity Studies of HSDB (2003). Moreover, there is a description, "Although K salt of this substance stimulated rabbits' eyes but not its skin," in the MOE Risk Assessment Vol 3 (2008). Moreover, when the cited literature from the MOE Risk Assessment Vol 6 (2008) referred for acute toxicity (oral), OECD: Co-operation on Existing Chemicals - Hazard Assessment of Perfluorooctane Sulfonate and its Salts.ENV/JM/RD (2002)17/FINAL.JT00135607, was checked, there was a description, "primary skin irritation scores; 0" in the skin irritation test with 6 rabbits. Because of the above-mentioned reasons it was classified into "Not classified".
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
In the paragraph of Animal Toxicity Studies of HSDB (2003), there is a description of "mildly irritating". Moreover, in MOE Risk Assessment, Volume 6 (2008), there is a description of "K salt of this substance stimulated the eyes of rabbits but not the skin." As mentioned above, it was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - Classification is not possible since there is no data.
5 Germ cell mutagenicity Not classified - - - - In the in vitro mutagenicity test, there is a description of "positive" (MOE Risk Assessment, Volume 6 (2008)) in the test employing the liver epithelium cell (WB-F344) of a rat and "negative" in the Ames test employing Salmonella typhimurium (NTP DB (Access on October 2008)). Although there is no data of the in vivo examination employable as this substance, since there is a description that "a micronucleus was not induced" in the body cell in vivo mutagenicity test (micronucleus test employing mouse bone marrow) when the data of the Potassium perfluorooctane-1-sulfonate (CAS number 2795-39-3) which is a substance with same water-solubility was adopted in MOE Risk Assessment Volume 6 (2008), it was classified into "Not classified".
6 Carcinogenicity Classification not possible - - - - Since no evaluation by main international evaluation organizations is made and data is inadequate, classification is not possible. In addition, although there is no data employable for this article, the 6th volume (2008) of the MOE Risk Assessment has a description, as a data of Potassium perfluorooctane-1-sulfonate (CAS number 2795-39-3) which is a relative substance, that "an significant dosage-depending increase of the hepatocellular was seen in male and female" in 104-week mixed-feed-administration examination employing male and female rats.
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
There is a description as follows in the forced oral administration study with rabbits of 7-20 day pregnancy, "10 out of 22 animals had miscarriage and significant low body weight of fetuses, sternebrae and delayed ossification were observed at the dose level where significant suppression of the body weight of mother animals was observed" (MOE Risk Assessment Vol.6 (2008). When thorough review of the cited literature, Oral (Stomach Tube) Developmental Toxicity Study of PFOS in Rabbits. Protocol No. 418-012. Argus Research Laboratories, Inc. U.S.EPA AR226-0949. (1999) was performed, there was a description as follows, "The miscarriage was dose dependent in high dose level groups and significantly so in the maximum dose level group. Breakdown of the 10 rabbits having miscarriage was 1 animal with 2.5mg/kg/day and 9 animals of the maximum dose level group with 3.75mg/kg/day." Based on the above-mentioned, it was classified in Category 1B.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Classification not possible due to lack of data
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Since there is no data applicable to the substance, classification is not possible. In addition, about the related substance, Potassium perfluorooctane-1-sulfonate (CAS number 2795-39-3), in the 90-day oral administration test to rats, "a significant increase in relative liver weight, an increase in absolute and relative adrenal gland weight, a significant decrease in absolute weight of thyroid and parathyroid, a significant decrease in absolute hypophysis weight were observed in male rats; a significant increase in absolute and relative liver weight was observed in female rats; a significant increase in relative kidney weight, weight reduction, a significant decrease in red blood count, in hemoglobin concentration, in hematocrit value and in white blood count, loss of color and tumor in the liver, loss of color in fundic gland mucosa, and hypertrophy of liver cells and circumscribed necrosis were seen in male and female rats" (MOE Risk Assessment vol. 6 (2008)). However, there is also the description that "since no changes in organ weight were detected in male rats in the high-dose group, its biological significance is unknown." Since these effects were seen within the limits of the guidance value of Category 1, it is classified into Category 1 (liver, blood systems).
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 2 from 96 hours LC50=3.34mg/L of the crustacea (Mysid) (MOE Risk Assessment (2008)).
11 Hazardous to the aquatic environment (Long-term) Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since acute toxicity was Category 2 and there were no rapid degradability (BIOWIN), it was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

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Model SDS by MHLW

MHLW Website (in Japanese Only)


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