GHS Classification Result

Chemical Name：4-Methylideneoxetan-2-one
CAS：674-82-8

Result：
ID: 1-421
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid
5 Gases under pressure Not applicable - - - - Liquid
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Since the flash point by IUCLID(2000) is 33degC(closed type), it was classified into Category 3.
7 Flammable solids Not applicable - - - - Liquid
8 Self-reactive substances and mixtures Not classified - - - - Although the unsaturated bond is included in molecule, it was classified into Not classified, since it was classified into Class 6.1(secondary risk 3) and PG I in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.2521(ICSC, 1998).
9 Pyrophoric liquids Not classified - - - - Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition point 275degC (ICSC,1998)).
10 Pyrophoric solids Not applicable - - - - Liquid
11 Self-heating substances and mixtures Classification not possible - - - - The test method suitable for liquid substances is not established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Although it is an organic compound including oxygen, not fluorine and chlorine, this oxygen has not chemically bound to any elements other than carbon.
14 Oxidizing solids Not applicable - - - - Liquid
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Classification not possible due to lack of data

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		From a description of LD50 value of 540 mg/kg and 613 mg/kg (IUCLID (2000)) in the oral administration test employing rats, it was classified into Category 4.
1 Acute toxicity （Dermal） Not classified - - - - Although there is a description of LD50 value of the dermal administration test employing a rabbit being 3,096 mg/kg and 6,730 mg/kg (IUCLID (2000)) and the lower value of 3,098 mg/kg corresponded to the U.N. GHS acute toxicity Category 5, it fell under unadopted category in Japan and was classified into "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It is written in IUCLID (2000) that LC50 values of the 4-hour inhalation exposure test employing rats are 0.311-0.686 mg/L (90.4-199 ppm), 0.94 mg/L (274 ppm), 0.82 mg/L (238 ppm) (IUCLID (2000)), etc., and LC50 value of the 1-hour inhalation exposure test employing rats is 551ppm. When the gas standard is applied from saturated vapor pressure level with 9,860 ppm (20degC)of this substance, 4-hour equivalent LC50 value for 1-hour exposure is 275 ppm. Although these data are within the scope of Category 1 or 2, it was classified into Category 2 since there were much data which correspond to Category 2. In addition, in EU classification, Xn; R20 (EU-Annex I).
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Since there is a description, "4.9 Draize units" (IUCLID (2000)) and the study of a cited literature (Ind. Hyg. Found. Am. Chem. Toxicol. Ser. Bull. 6 (1967)) showed the rsult corresponding to "moderate irritation", it was classified in Category 2. In addition, there are descriptions, "moderate"RTECS (2006) in the 24 hour Draize test with rabbits and "mild" in the study with rabbits. Moreover, there is a description, "corrosive, severe heat-burns in the eyes and skin" (HSDB (2003)).
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Since AOI 24, 48, and 72 hours after treatment were presumed to be 95/110, 95/110, and 85/110 from a description of "Draize scores of a conjunctiva, the iris, and a cornea are 24 hours after: 20/20, 5/10, 70/80, 48 hours after: 20/20, 5/10, 60/80" (IUCLID (2000)) in the test employing rabbits, it was classified into Category 1. In addition, there is a description of "corrosive, severe burns of the eye and the skin" HSDB (2003) as effect on humans.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - Classification is not possible since there is no data.
5 Germ cell mutagenicity Classification not possible - - - - Classification is not possible because there is no data of in vivo examination. In addition, there is a description of "positive" in the Ames test employing a Salmonella typhimurium (IUCLID (2000)).
6 Carcinogenicity Classification not possible - - - - Although there is a description as follows, "No tumor was observed during the study period" (IUCLID (2000)) in the dermal administration test with male mice and in another dermal administration test with female mice respectively, classification is not possible, because there is no study data with male and female rats used and evaluation by major international evaluation institutions has not been performed.
7 Reproductive toxicity Classification not possible - - - - Although there is a description as follows in HSDB (2003), "Fetal toxicity was not obseved with anaimal experiments and exposure to humans, classification is not possible due to insufficiency of data.
8 Specific target organ toxicity - Single exposure Category 2 (respiratory system) Warning H371: May cause damage to organs (respiratory system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Although there is a description of "lung dysfunction due to irritation to mucous membranes" (IUCLID (2000)) in the 4-hours inhalation exposure test employing rats and it is equivalent to Category 1, judging from the guidance value but is a information source of List2 and does not meet the criterion 1b3, according to the guidance, it was classified into Category 2 (respiratory systems). In addition, there is a description of "There is a possibility of lung blister, bronchus spasm, and bronchopneumonia" as a human acute symptom. (HSDB (2003))
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Classification not possible due to lack of data
10 Aspiration hazard Classification not possible - - - - Although the kinematic viscosity of the substance estimated from the viscosity of 0.88 mPa/s (the temperature is unknown) and the density of 1.0897 g/cm3 (HSDB (2003)) is 0.95 mm2/s and the viscosity at 40degC is expected to be 20.5 mm2/s, classification is not possible since the substance is not hydrocarbon.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 48 hours EC50=2.6mg/L of the crustacea (Daphnia magna) (Environmental Agency eco-toxicity tests of chemicals (1998)).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Although acute toxicity was Category 2, since there were rapid degradability (readily degradable, the decomposition by BOD(standard test method (4 weeks)): 99%(Existing Chemical Safety Inspections Data (1989))) and there were no bio-accumulation (log Kow=-0.39(PHYSPROP Database (2008))), it was classified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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