GHS Classification Result

Chemical Name：2-Methylnaphthalene
CAS：91-57-6

Result：
ID: 1-438-2）
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid
5 Gases under pressure Not applicable - - - - Solid
6 Flammable liquids Not applicable - - - - Solid
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid
10 Pyrophoric solids Not classified - - - - Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition temperature 529degC (Lide(88th,2007)).
11 Self-heating substances and mixtures Classification not possible - - - - The test method applicable for substances becoming liquid or gas at 140degC of test temperature has not been established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Solid
14 Oxidizing solids Not applicable - - - - It is an organic compound not containing oxygen, fluorine or chlorine.
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		FromLD50 value 1,630 mg/kg (6th volume (2008) of MOE risk assessment) of an oral administration test employing a rat, it was classified into Category 4. In addition, there is a description of female 3,180 mg/kg and male 4,200 mg/kg (IRIS (2003)) as LD50 value of the oral administration test employing a rat for 1:2 mixtures of 1-Methylnaphthalene and 2-Methylnaphthalene.
1 Acute toxicity （Dermal） Classification not possible - - - - Classification is not possible because there is no data. In addition, there is a description of LD50 value of the dermal administration test employing a female rabbit being 4,660 mg/kg (IRIS (2003)) for 1:2 mixtures of 1-Methylnaphthalene and 2-Methylnaphthalene.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification is not possible due to no data. In addition, as to 1:2 mixtures of 1-Methylnaphthalene and 2-Methylnaphthalene, it is written that adverse effects were not found in the test in which inhalation exposure of the saturated steam was carried out to rats for 6 hours (IRIS (2003)).
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Classification not possible - - - - Although there is s description, "There is skin irritation," in the section of Human Symptoms in HSDB (2005), classification is not possible, because the degree of stimulation is unknown. Incidentally, although there is a description, "Reddening is caused from contact with the skin, "in the Environmental Risk Evaluation Document Vol 6 (2008), it is not adopted, because this cited literature is from ICSC (1997) and skin irritation is not described in the section of Short Term Exposure. Moreover, there is a description, "irritating but not corrosive" in the study of the 1:2 composite of 1-Methylnaphthalene and 2-Methylnaphthalene (IRIS (2003)) applied to the skin of rabbits.
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		There is a description of "Eyes are stimulated."(Environment risk assessment, Volume 6 (2008)), and there is also a description of "Eyes are stimulated." in the paragraph of the short-term exposure effects of ICSC (1997). Although there is a description of "It has eyes irritation" in the paragraph of the the human symptoms of HSDB (2005), since any of the symptoms had unknown level and recoverability, it was not classified finely and was classified into Category 2.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - There is no data for this substance. Although there is a description of "cutaneous photosensitivity" (HSDB (2005)) as human influence of Methylnaphthalenes, classification is not possible because of lack of data.
5 Germ cell mutagenicity Classification not possible - - - - There are descriptions that "chromosomal aberration and sister chromatid exchange were not induced in lymphoid cell humans peripheral" (ATSDR (2005)), that "It was judged to be negative while the significant differences were found under metabolic activation conditions." in the in vitro SCE test employing a human lymphocyte (IRIS (2003)), and that it was "negative" in the reverse mutation test employing a Salmonella typhimurium (NTP DB (Access on January 2009)). However, classification is not possible because there is no data of an in vivo examination.
6 Carcinogenicity Not classified - - - - Since it was estimated I (IRIS (2003)) by EPA, according to guidance, it was classified into "Not classified". In addition, ACGIH-TLV/BEI (2005) has described that "evaluation of ACGIH TLV-NIC is A4", however, it is not evaluation of the whole ACGIH. Moreover, in the 81-week study which administered male and female mice with mixed feed, there is a description that "the increase with significant lung adenomas and lung adenocarcinoma was seen in males but not in females" (HSDB (2003)).
7 Reproductive toxicity Classification not possible - - - - Although there is a descriptionas follows in the 81 week oral administration study with male and female mice, "No damage was caused to male and female genital organs" (ATSDR (2005)), classification is not possible, because there is no datum for the effect on reproductive functions and child animals.
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects, Respiratory tract irritation） Warning H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation)
H335: May cause respiratory irritation (narcotic effects, respiratory tract irritation) 		P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is a description of "The front foot licking reaction time to heat stimulation increased dose-dependently and the significance was seen in the hypalgesia" within the range of the guidance value of Category 1 in 4-hours inhalation exposure test employing rats. (IRIS (2003))Moreover, in 6 minutes inhalation atmospheric exposure test employing male mice, the dose-dependent was seen in the lower respiratory rate, however the breathing rate recovered 12 minutes after the exposure stop. There is a description that authors believe that the respiratory change has occurred resulting from the irritation."(IRIS (2003))Furthermore, the clause of the human condition of HSDB (2004) has description of "There may be the irritation to the membrane and the upper airway, visual impairment, and coma." As mentioned above, it was classified into Category 3 (Narcotic effects, Respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Category 2 (lung) Warning H373: May cause damage to organs through prolonged or repeated exposure (lung) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In 81weeks mixed feed administration test employing mice, since there was a description of "The significant increase of alveolar proteinosis was observed."(IRIS (2003)), within the range of the guidance value of Category 2, it was classified into Category 2 (lungs). ICSC (1997) has described as "Lungs may be risked by repeated or long-term exposure." In addition, in the test where the mixture of 1-Methylnaphthalene and 2-Methylnaphthalene was applied to mice's skins for 30 weeks twice/week, there is a description of "Alveolar proteinosis was seen."(ATSDR (2005)).
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 48 hours EC50=1.4mg/L of the crustacea (Daphnia magna) (Environmental Agency eco-toxicity tests of chemicals (2000)).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since acute toxicity was Category 2 and there were no rapid degradability (BIOWIN), it was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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