GHS Classification Result

Chemical Name：Sodium alkyl(C16-18) sulfate
CAS：68955-20-4

Result：
ID: 2-007
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid
5 Gases under pressure Not applicable - - - - Solid
6 Flammable liquids Not applicable - - - - Solid
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid
10 Pyrophoric solids Not classified - - - - Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition temperature >400 degC (IUCLID,2000)).
11 Self-heating substances and mixtures Classification not possible - - - - The test method applicable for substances becoming liquid or gas at 140degC of test temperature has not been established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Solid
14 Oxidizing solids Classification not possible - - - - Classification not possible due to lack of data
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - It was classified into "Not classified" from LD50 value >2,000 mg/kg (SIDS (2007), IUCLID (2000)) of the oral administration test employing a rat (Directive 84/449/EEC, B.1, GLP).
1 Acute toxicity （Dermal） Classification not possible - - - - Classification is not possible because there is no data. In addition, for C12-13- and C10-16-Alkyl Sulfates, there is a description of LD50 value >500 mg/kg (SIDS (2007)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Not classified - - - - This substance has been described as causing "slight irritation" (SIDS (2007)) up to the concentration level of 31,5% in the skin irritation /corrosion test with rabbits (OECD TG 404, GLP). In addition, there is a description, "slightly irritating" (IUCLID (2000)) in the 4 hour sdministration study of this substance alone. It was classified into "Not classified" based on the above-mentioned.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		It is described as "mild irritant" at 25% concentration of this substance in rabbits (SIDS (2007)). On the other hand, it is described that although moderate to mild disability is seen in the cornea and the conjunctiva in eye irritation/corrosion test of this single substance (OECD TG 405, GLP), it recovers within one week and the irritation index is 4.2 (IUCLID (2000)). As mentioned above, it was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Not classified - - - - It was classified into "Not classified" from descriptions of no skin sensitization (IUCLID (2000)) in the Maximization test employing guinea pig (OECD TG 406, GLP) and of no skin sensitization in the OECD TG/406 test with alkyl sulfate (SIDS (2007)).
5 Germ cell mutagenicity Classification not possible - - - - Although there is a description that alkyl sulfates do not show genotoxicity in the micronucleus test, chromosome aberration test, and dominant lethal test employing a mouse in vivo (SIDS (2007)), classification is not possible because the details about this substance were not described. In an in vitro, it is described that it is negative in the Ames test employing bacteria (OECD TG/471, GLP) (IUCLID (2000)) and Alkyl Sulfates do not show mutagenicity in the test employing bacterial and mammalian cultured cells (SIDS (2007).
6 Carcinogenicity Classification not possible - - - - Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible. In addition, it is described that Alkyl Sulfates (C12-15 ASO4 sodium) did not indicate carcinogenicity by the two-year mixed-feed-administration examination employing rats (SIDS (2007)).
7 Reproductive toxicity Classification not possible - - - - It is described in the developmental toxicity study of various Alkyl Sulfates including this substance using rats, mice and rabbits that generation of effects on children (fetal death, increase in the number of fetal death from the same litter) is limited to the dose level (300-500mg/kg for rats) where effects on mother animals (anorexia, body weight decrease and death) are markedly observed (SIDS (2007)). Although effects on child animals can be assumed to be the secondary effect of mother animals, classification is not possible, because no determination can be made.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - In the acute oral administration study employing rats and mice of alkyl sulfate, there is a description that lethargy and motor ataxia are seen, but not pecific (SIDS (2007)), and details of such recovery nature are unknown, therefore, classification is not possible.
9 Specific target organ toxicity - Repeated exposure Not classified - - - - There is a description that hepatotoxic (parenchymal hypertrophy, increase in relative weight) was seen in 13 weeks mixed feed administration test employing rats (SIDS (2007)) and effects are not seen in 90-days oral administration test employing rats (OECD TG 408, GLP) (IUCLID (2000)). These are the test results outside of the range of the guidance value of Category 2. As mentioned above, it was classified into "Not classified ".
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 96 hours LC50=5.2mg/L of the fish (Zebrafish) (IUCLID (2000)).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since acute toxicity was Category 2 and there were no rapid degradability (BIOWIN), it was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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