Chemical Name：(1'S,6'R)-7-Chloro-2',4,6-trimethoxy-6'-methyl-3H-spiro[benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione
CAS：126-07-8

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	In the information on List3, since LD50 value of the oral administration test employing a rat is >10,000 mg/kg (RTECS (1982)), it was classified into "Not classified".
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	Classification not possible due to lack of data
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	Classification not possible due to lack of data
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	Classification not possible due to lack of data
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	Classification not possible due to lack of data
3	Serious eye damage/eye irritation	Classification not possible	-	-	-	-	Classification not possible due to lack of data
4	Respiratory sensitization	Classification not possible	-	-	-	-	Classification is not possible since there is no data.
4	Skin sensitization	Classification not possible	-	-	-	-	Classification is not possible since there is no data.
5	Germ cell mutagenicity	Category 1B		Danger	H340: May cause genetic defects	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	It was classified into Category 1B from the statement of "positive" (IARC 79 (2001)) in the in vivo mutagenicity test (chromosome aberration test employing a mouse spermatocytes) employing a germ cell.
6	Carcinogenicity	Category 2		Warning	H351: Suspected of causing cancer	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Since it was group 2B (IARC 79 (2001)) in IARC, it classified into Category 2.
7	Reproductive toxicity	Category 1B		Danger	H360: May damage fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	In an oral administration study in 6-15 day pregnant rats, it is reported that "malformations such as malformation of tails, anophthalmos, aproctia and exencephaly were observed" (IARC 79 (2001)). These malformations were not dose-dependent, but when we checked this reference article (Science 175 (1972)), it is reported that an increase in embryonic absorption, decreased fetal weight and abnormalities in tails were observed at doses at which decreased weight is observed in mother rats. For the reasons stated above, it was classified as Category 1B. In addition, there is a report of "possible fetotoxicity when administered to pregnant women" (HSDB (2002)).
8	Specific target organ toxicity - Single exposure	Category 2 (systemic toxicity)		Warning	H371: May cause damage to organs (systemic toxicity)	P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ...	About humans, there is a description of "high frequency symptom: headache / low frequency symptom: nausea, vomiting, diarrhea, heartburn, angle stomatitis, insomnia, and unusual tiredness" (HSDB (2002)). As mentioned above, it classified into Category 2 (systemic toxicity).
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver, skin)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (liver, skin)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	For humans, IARC 79 (2001) has description of "Inhibition of Porphyrin metabolism" and when this cited literature (Crit.Rev.Toxicol.27 (1997)) was investigated, "Damage to hepatic cells, necrosis, and inflammation occur in sequence to the Porphyrin accumulation which this substance has caused in the mouse liver. Although the similar change was known as porphyria related to the increased risk of human hepatocytes oncogenesis, there was a description that the Porphyrin occurrence (porphyrogenic) effect of human in administration of this substance was moderate compared with that of the mouse model," For laboratory animals, it has been described to be "formation of hypertrophy of liver, liver cell damage, necrosis, porphyria with inflammation, and the Malory object formulation, and hypertrophied thyroid gland" in IARC 79 (2001). Although this influence in the liver in the animal was seen out of the range of the guidance value of Category 2, since when the description of the cited literature of IARC 79 (2001) was taken into consideration, hazard to humans was not able to deny , it was classified into Category 2 (liver). Moreover, in HSDB (2002), for humans, there is a description of "There were reactions of chill hives, , warm hives and light anaphylaxis, lichen plan, erythema, polymorphism erythema, anthema like blister, rash like measle, and the like", and when this cited literature (Gilman, A.G., and T.W.Rall, A.S.Nies and P.Taylor (eds.).). Goodman and Gilman's The Pharmacological Basis of Therapeutics.8th ed. (1990) was investigated, it has been described that this substance was an oral drug and had adverse effect on the skin, thus, it was classified into Category 2 (skin). As mentioned above, it was classified into Category 2 (liver, skin) as a whole. In addition (HSDB (2002)) has described that administration to the patients with acute porphyrias, liver dysfunctions patients, drugs hypersensitivity patients, pregnant women is prohibited.
10	Aspiration hazard	Classification not possible	-	-	-	-	Classification not possible due to lack of data