GHS Classification Result

Chemical Name:2,4-Dichloro-1-nitrobenzene
CAS:611-06-3

Result:
ID: 2-029
Classifier: Ministry of Economy, Trade and Industry (METI), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Although the nitro group is included in chemical structure and the calculation value of oxygen balance is -29, there is no data of onset of exothermic decomposition and decomposition energy. Since it was classified into Class 6.1 and PG II in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1578(ICSC, 1996)), it was classified into Not classified.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid
5 Gases under pressure Not applicable - - - - Solid
6 Flammable liquids Not applicable - - - - Solid
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data
8 Self-reactive substances and mixtures Not classified - - - - Although the nitro group is included in chemical structure, it was classified into Not classified, since it was classified into Class 6.1(not 4.1) and PG II in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1578(ICSC, 1996)).
9 Pyrophoric liquids Not applicable - - - - Solid
10 Pyrophoric solids Not classified - - - - Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition temperature 500degC (IUCLID,2000)).
11 Self-heating substances and mixtures Classification not possible - - - - The test method applicable for substances becoming liquid or gas at 140degC of test temperature has not been established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Solid
14 Oxidizing solids Classification not possible - - - - Although it is an organic compound including oxygen having chemically bound to elements other than carbon and hydrogen, classification is not possible due to lack of data.
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
From LD50 value 990 mg/kg (SIDS (1996)) in the oral administration test employing rats, it was classified into Category 4.
1 Acute toxicity (Dermal) Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
Since LD50 value of the dermal administration test employing rats was 921 mg/kg (SIDS (1996)), it was classified into Category 3.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Not classified - - - - Based on descriptions "Slightly irritating" (SIDS (1996)) in the patch test with rabbits and "Slightly irritating" (IUCLID (2000)) in the skin irritation/corrosion test (OECD TG 404, GLP), it was classified into "Not classified".
3 Serious eye damage/eye irritation Not classified - - - - From the description of "Slightly irritating" (SIDS (1996)) and "Slightly irritating" in eye irritation/corrosion test (OECD TG 405, GLP) (IUCLID (2000)) in a rabbit, it was classified into "Not classified".
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
It was classified into Category 1 from description of possible sensitization (IUCLID (2000)) in the Maximization test employing guinea pig (OECD TG 406, GLP).
5 Germ cell mutagenicity Classification not possible - - - - Although there is a description of positive (SIDS (1996)) in the reverse mutation test employing in vitro bacteria and negative in the chromosome aberration test employing Chinese hamster culture cells (the Health, Labor and Welfare Ministry reports (Access on September 2008), SIDS (1996)), classification is not possible because there is no data of in vivo examination.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
The carcinogenicityity study by the 104-week oral administration employing rats and mice has a description that "increased incidences of kidney cell carcinomas cells and adenomas were deemed in male and female rats, and it was regarded as a clear evidence of indicating carcinogenicityity. Moreover, increased incidences of Tyson's glands adenomas was deemed in the male. Increased incidences of hepatocellular carcinomas, hepatoblastoma, hepatocellular adenomas, angiosarcoma of peritoneal was deemed in male and female mice, and it was regarded as a clear evidence of indicatign carcinogenicityity" (Ministry of Health, Labour and Welfare carcinogenicityity examination (2004)). Therefore, the carcinogenicityity in the animal was acknowledged. However, since application to humans was unknown, it was classified into Category 2.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
In a combined repeated dose toxicity study and reproductive/developmental toxicity screening study in rats (OECD TG 422, GLP), it is reported that no effects on mating fertility and estrous cycles were observed, but at 200 mg/kg, the dose at which toxicities (effects on the liver and kidney) manifest themselves in mother rats, two animals were stillborn and three female offspring rats died during the breast-feeding period, so the substance has effects on female reproduction and generation/development of the offspring (Ministry of Health, Labor and Welfare Report (Access on September 2008), SIDS (1996)). Therefore, it was classified as Category 2.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Classification not possible due to lack of data
9 Specific target organ toxicity - Repeated exposure Category 2 (liver, kidney) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver, kidney) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
It is written in the combination test of repeated dose toxicity study and reproduction screening study in rats (OECD TG 422, GLP) that effects on liver (hypertrophy of hepatocytes, and necrosis, etc.) and kidney (creatinine low level, necrosis of tubular epithelium, basophilic tubule change, etc.) were found, and target organs were considered to be liver and kidney (Ministry of Health, Labour and Welfare reports (Access on September 2008), SIDS (1996)). Since these effects were found within the scope of the guidance value of Category 2, it was classified into Category 2 (liver, kidney).
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 2 from 72 hours ErC50=2.0mg/L of the algae (Pseudokirchneriella subcapitata) (SIDS (2005)).
11 Hazardous to the aquatic environment (Long-term) Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since acute toxicity was Category 2 and there were no rapid degradability (not readily degradable, the decomposition by BOD(standard test method (4 weeks)): 0% (Existing Chemical Safety Inspections Data (1995)), it was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

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Model SDS by MHLW

MHLW Website (in Japanese Only)


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