GHS Classification Result

Chemical Name：2-[(Thiocyanatomethyl)sulfanyl]-1,3-benzothiazole
CAS：21564-17-0

Result：
ID: 2-057
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid
5 Gases under pressure Not applicable - - - - Liquid
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Since the flash point by Merck(14th,2006) is 66degC(open type), it was classified into Category 4.
7 Flammable solids Not applicable - - - - Liquid
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Classification not possible - - - - Classification not possible due to lack of data
10 Pyrophoric solids Not applicable - - - - Liquid
11 Self-heating substances and mixtures Classification not possible - - - - The test method suitable for liquid substances is not established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - It is an organic compound not containing oxygen, fluorine or chlorine.
14 Oxidizing solids Not applicable - - - - Liquid
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Classification not possible due to lack of data

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		From a description of lower value of 750 mg/kg among LD50 value of 750 mg/kg (CERI/NITE Hazard Assessment Report (2008)) and 1,590 mg/kg (HSDB (2003)) in the oral administration test employing rats, it was classified into Category 4.
1 Acute toxicity （Dermal） Not classified - - - - From a description of LD50 value of >2,000 mg/kg (CERI/NITE Hazard Assessment Report (2008)) in the dermal administration test employing rabbits, it was classified into "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Dusts and mists） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Saturated vapor pressure level at 25degCis 0.00041 ppm (4*10^-6 mg/L). Since LC50 value with 0.1 mg/L of 4-hour inhalation exposure test employing rats (CERI/NITE Hazard Assessment Report (2008)) was larger than saturated vapor pressure level, it was classified into Category 2 by applying the dust and mist standard.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		There is a description, "strong skin irritation" (CERI/NITE Hazard Assessment Report (2008)) in the dermal stimulation study with rabbits. Furthermore, when a cited literature, U.S. EPA 73-R-05-003 (2006) was checked, there was a description, "The score 72 hours later was 7.42 and severe erythema and edema were observed." Since there is no descriptipn of irreversibility, it was classified in Category 2. Incidentally, EU division is Xi; R36/38 EU-Annex I)
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		There is a description of "Moderate" (RTECS (2008)) in the eye irritation test employing rabbits. Furthermore, when U.S.EPA 739-R-05-003 (2006) which is a cited literature in other clauses was checked, it was described that it was classified into "corrosive from the score: 34/110 in the ophthalmological eye irritation test employing rabbits." , and "The condition of the anemia conjunctiva, conjunctiva dropsy, and corneal opacity was not recovered in seven days". As mentioned above, it was classified into Category 2A. In addition, EU classification is Xi; R36/38 (EU-Annex I) and is equivalent to Category 2. On the other hand, "Caustic is shown to an eye" is described in ICSC (J) and (1997).
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		It has been described in the CERI/NITE Hazard Assessment Report (2008) that "strong skin sensitization was observed in the Maximization tests employing guinea pig." Furthermore, it has been described that "it is a sensitizing substance in humans" in the cited literature, U.S.EPA 739-R-05-003 (2006). Therefore, it was classified into Category 1. In addition, it can be classified as Xi; R43 (EU-Annex I) in the European Union classification, which is equivalent to Category 1.
5 Germ cell mutagenicity Not classified - - - - From a description of "negative" (CERI/NITE Hazard Assessment Report (2008)) in the body cell in vivo mutagenicity test (the chromosome aberration test employing rats bone marrow cell, the micronucleus test using a mouse), it was classified into "Not classified".
6 Carcinogenicity Classification not possible - - - - There is a description that "Although it is classified as group C according to EPA in 1995, it is not evaluated by other international organizations" (CERI/NITE Hazard Assessment Report (2008)). By scrutinizing of the citation (A review of the environmental impact and toxic effects of TCMTB. (1991)), we found a description that "Carcinogenicity was not deemed in the test employing rats and mice which were administered with mixed feed for 104 weeks ". Moreover, the EPA report which described this evalutation (U. S.EPA 739-R-05-003 (2006)) showed that "carcinogenicity was not deemed in the 104-week mixed-feed-administration examination employing rats," therefore, it is classified into "Not classified", but for the moment, classification is not possible since it is not a final conclusion.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Because of a report that "an increase in abnormalities such as fused/undulated ribs was observed in fetuses at doses at which toxic effects such as decreased weight gain manifested themselves in mother animals" (CERI/NITE Hazard Assessment Report (2008)) in a reproductive toxicity study in rats, it was classified as Category 2.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - CERI/NITE Hazard Assessment Report (2008) has a description that "main symptoms observed in rats administered TCMTB orally were slowness of operation and an irregular walk, and were recovered in three to seven days after administration in the survived examples", however, classification is not possible since it is unknown about details, such as dose.
9 Specific target organ toxicity - Repeated exposure Category 2 (stomach) Warning H373: May cause damage to organs through prolonged or repeated exposure (stomach) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In CERI/NITE Hazard Assessment Report (2008) there are reports of "squamous epithelial cell hyperplasia in the stomach" in a 13-week feeding study in rats, "degeneration with inflammation, edema and necrosis of squamous epithelial cells and ulcers in anterior stomach mucous membrane" in a 90-day feeding study in rats, and "leukopenia and monocytopenia" in a 52-week feeding study in dogs. When we reviewed "A review of the environmental impact and toxic effects of TCMTB (1991))", one of the references for the 52-day feeding study in dogs, it states that there is "no significant effects," and there are no reports of leukopenia and monocytopenia. The effects on the stomach are seen to be within the range of guidance values for Category 2. For the reasons stated above, it was classified as Category 2 (stomach).
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96 hours LC50=0.0087mg/L of the fish (Bluegill) (Hazard Assessment Report (2007)).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since acute toxicity was Category 1 and there were no rapid degradability (not readily degradable, the decomposition by BOD: 0% (standard test method (4 weeks)) (Existing Chemical Safety Inspections Data (1990))), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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