GHS Classification Result

Chemical Name:1,1':2',1''-Terphenyl
CAS:84-15-1

Result:
ID: 2-063
Classifier: Ministry of Economy, Trade and Industry (METI), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid
5 Gases under pressure Not applicable - - - - Solid
6 Flammable liquids Not applicable - - - - Solid
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid
10 Pyrophoric solids Classification not possible - - - - Classification not possible due to lack of data
11 Self-heating substances and mixtures Classification not possible - - - - The test method applicable for substances becoming liquid or gas at 140degC of test temperature has not been established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Solid
14 Oxidizing solids Not applicable - - - - It is an organic compound not containing oxygen, fluorine or chlorine.
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
From a description of LD50 value of 1,900 mg/kg (ACGIH (7th, 2001), Patty (5th, 2001)) in the oral administration test employing rats, it was classified into Category 4.
1 Acute toxicity (Dermal) Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity (Inhalation: Dusts and mists) Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
This substance is a solid whose saturated vapor pressure level at 25degCis 0.003 mg/L. As a result of having investigated the cited reference (Toxicol.Appl.Pharmacol.1 (1959)) about an inhalation exposure test employing rats described in ACGIH (7th, 2001), it said that there were 4/8 mortality in the high concentration, and no mortality in the low concentration in the 1-hour inhalation exposure test by 2 concentrations (3.56 mg/L, 0.88 mg/L) employing male and female rats. Therefore, when LC50 value was judged to be 3.56 mg/L and the dust standard was applied, it was classified into Category 3 from 4-hour equivalent LC50 value with 0.89 mg/L. In addition, this cited reference covers Terphenyl which contains this substance as one of isomeric forms.
2 Skin corrosion/irritation Classification not possible - - - - When investigating the cited literature (Toxicol. Appl. Pharmacol. 1 (1959)) from description that Terphenyl of isomer mixture had a "moderate" irritatin on rabbitsis (ACGIH (7th, 2001)), there has been a description of "Draize score= 0/ 8" in the skin irritation test (the Draize method) employing rabbits with o-Terphenyl. However, since only this information is one "Not classified", classification is not possible. In addition, the paragraph of the effects of short term exposure in ICSC (2004) has a description that "the skin is stimulated." Moreover, for hazardous property, also refer to Terphenyl including this substance (ID 847, CAS No.26140-60-3).
3 Serious eye damage/eye irritation Classification not possible - - - - From the description that Terphenyl which is an isomer mixture has excessive irritation to a conjunctiva" (ACGIH (7th, 2001)) against rabbits and when a cited literature (Toxicol.Appl.Pharmacol.1 (1959)) was investigated, there was a description of "no influence" in the eye irritation test (the Draize method) employing rabbit of o-Terphenyl, but since this is the only information that corresponds to "Not classified ", classification is not possible. In addition, the paragraph of the effects of short-term exposure in ICSC (2004) has description of "an eye is stimulated." Moreover, also refer to Terphenyl (ID 847, CAS No.26140-60-3) including this substance for hazard.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - Although the cited literature (Toxicol. Appl. Pharmacol. 1 (1959)) was investigated from description that Terphenyl of isomer mixture showed more damages (necrosis and allergic symptoms) on guinea pig (ACGIH (7th, 2001)), classification is not possible because of lack of information.
5 Germ cell mutagenicity Classification not possible - - - - Classification is not possible because there is no data of in vivo examination.In addition, there is a description of "negative" in the in vitro mutagenicity test (mutation assay using Salmonella typhimurium TM677) (HSDB (2005)).
6 Carcinogenicity Classification not possible - - - - Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible.
7 Reproductive toxicity Classification not possible - - - - Classification not possible due to lack of data
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation) Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
The information source of List1 has a description on Terphenyl, isomeric mixture, that "headache and pain of throat was seen in human short term exposure, however, it was recovered within 24 hours" (Patty (5th, 2001)), and it was classified into Category 3 (Respiratory tract irritation) since this article is considered to have the same effect. In addition, ICSC (2004) has a description that "an airway is stimulated" as effect of short terms exposure.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - It is written that in 30-day oral administration test in rats, there were "slight weight reduction by dose 250 mg/kg, and increase in the liver weight and kidney weight to weight " (ACGIH (7th, 2001)), Patty (2001)), and in histopathologic finding , "it was similar to control groups, (ACGIH (7th, 2001)), and "there were no effects on administration" (USCh (2003)), however, classification is not possible since data is insufficient.
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 96 hours LC50=0.12mg/L of the fish (Oryzias Latipes) (Environmental Agency eco-toxicity tests of chemicals (1995)).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since acute toxicity was Category 1 and there were no rapid degradability (BIOWIN), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

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Model SDS by MHLW

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