GHS Classification Result

Chemical Name:4,4'-Bipyridyl
CAS:553-26-4

Result:
ID: 2-075
Classifier: Ministry of Economy, Trade and Industry (METI), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid
5 Gases under pressure Not applicable - - - - Solid
6 Flammable liquids Not applicable - - - - Solid
7 Flammable solids Not classified - - - - Since it was classified into Class 6.1 and PG III in the United Nations Recommendations on the Transport of Dangerous Goods ((UN No.2811), it was classified into Not classified. In addition, this TDG classification is based on the UN number by Merck KGaA data from March 2009.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid
10 Pyrophoric solids Not classified - - - - Since it was classified into Class 6.1 and PG III in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.2811). In addition, this TDG classification is based on the UN number by Merck KGaA data from March 2009.
11 Self-heating substances and mixtures Classification not possible - - - - The test method applicable for substances becoming liquid or gas at 140degC of test temperature has not been established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Solid
14 Oxidizing solids Not applicable - - - - It is an organic compound not containing oxygen, fluorine or chlorine.
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
From LD50 value of 400 mg/kg and 172 mg/kg (female)-175 mg/kg (male) (IUCLID (2000)) of the oral administration test employing a rat, the lower value was adopted and it was classified into Category 3.
1 Acute toxicity (Dermal) Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
Since LD50 value of the dermal administration test employing rats was 400-800 mg/kg (IUCLID (2000)), it was classified into Category 3.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - It is written that LC50 value of 4-hour inhalation exposure test employing rats is >0.16 mg/L (IUCLID (2000)). Although the dust standard was applied to this substance from saturated vapor pressure level with 0.013 mg/L (25degC), classification cannot be specified, and classification is not possible.
2 Skin corrosion/irritation Classification not possible - - - - Although there is a description, "not irritating" (IUCLID (2000)) for the 24 hour skin irritation test using rats in the information source of List 2, classification is not possible, because details are unknown nor other data available.
3 Serious eye damage/eye irritation Classification not possible - - - - Classification not possible due to lack of data
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - Although there is a description of "not sensitizing" in the skin sensitivity test employing guinea pig (IUCLID (2000)), classification is not possible because of no other data.
5 Germ cell mutagenicity Classification not possible - - - - Classification is not possible because there is no data of in vivo examination. In addition, there is a description of "negative" in the in vitro reverse mutation test (mutations test employing a Salmonella typhimurium (GLP)) (IUCLID (2000)).
6 Carcinogenicity Classification not possible - - - - Classification is not possible due to insufficiency of data, because evaluation by major international evaluation institutions has not been performed. Incidentally, there is a description as follows, "Tumors were not found in the skin or other tissues."(IUCLID (2000)) in the 104 week dermal administration test (GLP) using male and female mice.
7 Reproductive toxicity Classification not possible - - - - Classification not possible due to lack of data
8 Specific target organ toxicity - Single exposure Category 2 (lung) Warning H371: May cause damage to organs (lung) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
According to the cited reference of IUCLID (2000) (J. Toxicol.Environ.Health.10 (1982)), there is a description that "with non-lethality dose (female: 100 mg/kg, male: 150 mg/kg), symptom and pathological findings change was not deemed but the deemed symptom was somnolence only in the oral administration test employing a rat. The fatality reaction curve of this substance is a steep slope, and the least fatal doses of female and male rats are 130 mg/kg and 160 mg/kg, respectively. Dead animals have lung hemorrhage, lung dropsy, intra-alveolar bleeding, atelectatic lung, and the congestion was also regarded in lungs, the kidney, and the lien. Moreover, taking into consideration the fact that agricultural-chemicals paraquat which is the dimethyl compound of this substance characteristically damage lungs, it is presumed that this substance's target internal organs are also lungs. In addition, although such symptom was equivalent to Category 1 by judging from the guidance value, it was classified into Category 2 (pneumoconiosiss) according to this guidance because it was data of List2, and doesn't meet the acceptance criteria 1b 3).
9 Specific target organ toxicity - Repeated exposure Category 2 (kidney) Warning H373: May cause damage to organs through prolonged or repeated exposure (kidney) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In the document (J. Toxicol.Environ.Health.10 (1982)) cited from the 3-month oral administration test in male and female rats (IUCLID (2000)), there is the description that "concretion and kidney sclerosis (nephrosclerosis) were observed." Although effects on kidney were observed within the dosage in the Category 1 guidance value range, the substance is classified into Category 2 (kidney) according to this guidance because that is the data for List 2 and does not meet the criteria of 1 b3.
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - Classification not possible due to lack of data
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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