Chemical Name：(5-Benzyl-3-furyl)methyl 2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropanecarboxylate
CAS：10453-86-8

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 4		Warning	H302: Harmful if swallowed	P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ...	There is a description that LD50 values of the oral administration test employing a rat are >5,000 mg/kg, 1,987 mg/kg, 960 mg/kg (EHC 92 (1989)), >2,500 mg/kg, 1,721 mg/kg, 1,244 mg/kg (EHC 92 (1989), HSDB (2001)), and 1,400 mg/kg (HSDB (2001)). Since all definite values corresponded to Category 4, it was classified into Category 4. In addition, in EU classification, it is Xn; R22 (EU-Annex I).
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Since LD50 value of the dermal administration test employing rats was >2,500 mg/kg (EHC 92 (1989)) and >3,000 mg/kg (HSDB (2001)), and LD50 value of the dermal administration test employing rabbits was >2,500 mg/kg (EHC 92 (1989)), it was classified into "Not classified".
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	Classification not possible due to lack of data
1	Acute toxicity （Inhalation: Dusts and mists）	Not classified	-	-	-	-	It is written that LC50 value of 4-hour aerosol inhalation exposure test employing rats is >9.49 mg/L, and LC50 value of 1-hour aerosol inhalation exposure test employing rats is >12.0 mg/L (4-hour equivalent: >4.9 mg/L) (EHC 92 (1989)). Since LC50 value was >9.49 mg/L, it was classified into "Not classified".
2	Skin corrosion/irritation	Not classified	-	-	-	-	Although there is a description, "irritates the skin" in the section of Effects of Short Term Exposure in ICSC (2001), "slight irritant" is described for the skin irritation test using Resmethrin rabbits' ears in EHC 92 (1989) that is the information source for List 1. In addition, there is a description, "There is no skin irritation" (EHC 92 (1989, JMPR (1991))) in the skin irritation test using Bioresmethrin rabbits' ears that are the component of this substance. The "slight irritant" is deemed to correspond to GHS Skin irritation Category 3, but classified into "Not classified", because it is a division not domestically adopted.
3	Serious eye damage/eye irritation	Classification not possible	-	-	-	-	Although in the section of the effects of short-term exposure of ICSC (2001), there is a description of "An eye is stimulated," details, such as the level of the stimulus are unknown. Although there is a description of "There is no eyes irritation." in the eye irritation test employing a rabbit (EHC 92 (1989), JMPR (1991)) for Bioresmethrin which is a component of this substance, since there is no data of this substance, classification is not possible due to insufficient data.
4	Respiratory sensitization	Classification not possible	-	-	-	-	Classification is not possible since there is no data.
4	Skin sensitization	Classification not possible	-	-	-	-	There is a description that "guinea pig did not indicate skin sensitizations" (EHC 92 (1989)). Moreover, for Bioresmethrin which is a component of this substance, although there are descriptions that "skin sensitization was not shown" (JMPR (1991)) and that "a potential sensitization is low only with slight erythema" (EHC 92 (1989), JMPR (1991)) in the sensitization tests with guinea pig, the substance cannot be classified because of insufficient data since it has no other data.
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	Classification is not possible because there is no data of in vivo examination. In addition, there is a description of "negative" in the reverse mutation test employing Salmonella typhimurium and bacillus coli, chromosome aberration test employing a Chinese hamster cultured cell and mouse bone marrow cells, and the mutation assay employing Chinese hamster V79 cell as in vitro mutagenicity tests (EHC 92 (1989)).
6	Carcinogenicity	Classification not possible	-	-	-	-	Since no evaluation by major international evaluation agencies is made and there is no sufficient data, classification is not possible. In addition, there is a description that "carcinogenicity was not foreseen by highest dose, either" in the 85-week oral administration study employing mice and the 112-week oral administration study employing rats (EHC 92 (1989)).
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	There is a description as follows in NTP DB (Access on November 2008), "There is no reproductive toxicity against animals but data are not available for humans." Moreover, there is a description as follows in EHC 92 (1989), "Teratogenicity was not observed" in the teratogenicity study via oral administration using rats and mice. On the other hand, there is a description as follows in the 3 generation study with mixed food administration using rats, " Statistically apparent increase in the number of low body weight children and still birth was observed"(EHC 92 (1990), IRIS (2002)) but it was classified in Category 2, because the effect of toxicity on parent animals at the same dose level is unknown without reviewing primary documents.
8	Specific target organ toxicity - Single exposure	Category 2 (central nervous system)		Warning	H371: May cause damage to organs (central nervous system)	P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ...	There is a description that the animal exposed to Resmethrin "shows nerve tremor, excitement, convulsive muscle contraction, collapse, and coma" as acute symptoms (EHC 92 (1989)). Moreover, when the cited literature of the test data described in HSDB (2001) (Environ.Health Perspect.14 (1976)) was investigated, there were descriptions of "Nerve tremor and ataxia were seen 30 minutes to 3 hours after exposure, sensitive reaction in the oral administration test employing rats and mice of Resmethrin and of "Ataxia and incontinence of urine were seen at the time of high concentration exposure." in 4 hours mist inhalation exposure test for employing rats and mice of , (+)-Trans & Cis-reaction." This substance consists of four sorts of isomer mixtures. In consideration of the degree of the toxicity varying depending on compounding ratio, the central nervous system was considered to be the target organ from these findings. Moreover, since the effect was seen within the range of the guidance value of Category 2, it was classified into Category 2 (central nervous system). In addition, the section of the effect of short term exposures in ICSC (2002) has a description of "The nervous system may be affected" for Cis-resmethrin which is one of the composition ingredients of this substance.
9	Specific target organ toxicity - Repeated exposure	Category 2 (central nervous system)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (central nervous system)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	It is written in carcinogenicity examination by 2-year oral administration in rats that"hypertrophy of hepatocytes and decrease in lien weight of female rats were found" (IRIS (2002)). Moreover, it is written in EHC 92 (1989) that in 90- day inhalation exposure test in rats that "minute clinical findings and irritating property findings were found in level of exposure 0.3 mg/L, however, histopathology findings by administration were not found in lungs or other organs, and in 112-week oral study in rats that "hypertrophy of hepatocytes was found, however, it was not classified into specific virulence response". In addition, "weight reduction, feed intake reduction, increase in liver weight, and tremulousness were described as common findings in the oral study in a number of rats, it was classified into Category 2 (central nervous systems) because tremor symptoms were found within the scope of the guidance value of Category 2.
10	Aspiration hazard	Classification not possible	-	-	-	-	Classification not possible due to lack of data

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 96 hours LC50=0.000275mg/L of the fish (Rainbow Trout) (EHC 92 (1989)).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since acute toxicity was Category 1 and there were no rapid degradability (not readily degradable, the decomposition by BOD: -4% (standard test method (4 weeks)) (Existing Chemical Safety Inspections Data (2007))), it was classified into Category 1.