Chemical Name：2,2'-methylenebis-(3,4,6-trichlorophenol); hexachlorophene
CAS：70-30-4

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 3		Danger	H301: Toxic if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the rat (male) LD50 of 66mg/kg (IARC vol.20 (1979)) and the rat (female) LD50 of 56mg/kg (IARC vol.20 (1979)), the substance was classified into Category 3.
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available.
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	No data available.
3	Serious eye damage/eye irritation	Classification not possible	-	-	-	-	No data available.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	No data available.
5	Germ cell mutagenicity	Not classified	-	-	-	-	The substance was classified into "Not classified" based on negative results obtained from dominant lethal tests using mice (in vivo heritable mutagenicity tests) (IARC vol. 20 (1979)). In addition, negative results have been obtained from chromosomal aberration tests using human lymphocytes (IARC (1979)).
6	Carcinogenicity	Not classified	-	-	-	-	The substance was classified into "Not classified" since it has been classified into Group 3 by IARC, and since there was no statistically significant increase in tumorigenesis in any of the organs tested in rat carcinogenicity studies (NTP TR40 (1978).
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	The substance was classified into Category 2 since teratogenesis, such as cleft palates, microphthalmia/anophthalmia, and wavy ribs, were observed at the dose toxic to maternal rats that underwent oral route exposure (some of the rats received intravaginal administration) (IARC vol. 20 (1979), Catalog of teratogenic Agents), and infrequent costal malformation has been reported in rabbits that underwent oral route exposure during the organogenetic period (IARC vol. 20 (1979), Catalog of Teratogenic Agents). Additionally, in humans, serious cases of malformation, such as defects in the eyes and the central nervous system of the children born from mothers who were exposed to hexachlorophene, have been reported (IARC vol. 20 (1979), Catalog of teratogenic Agents). However, the relevance of hexachlorophene as the cause of malformation has been reevaluated and rejected.
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system, visual system)		Danger	H370: Causes damage to organs (nervous system, visual system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Several cases of children with serious conditions due to accidental exposure to the substance have been reported (HSDB (2003)). These symptoms include loss of eyesight, lethargy, and convulsions. Severe cerebral edema was observed by autopsy, and in conspicuous cases, dead children had disintegration and necrosis of myelin sheath and optic nerve axons (HSDB (2003)). Furthermore, there is a description that neurologic symptoms in neonates after acute exposure probably result from cerebral edema (HSDB (2003)). From these documentations, its effects on human nervous system are clear, and thus, the substance was classified into Category 1 (nervous system / optic system).
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (nervous system)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	Oral route exposure of 0.75-3.0mg/kg/day for 13 weeks resulted in spongiform of the brain, optic nerve, spinal cord and schiatic nerve at all doses tested for dogs (IRIS (2002)), and oral route exposure of 5mg/kg/day for 16 weeks was linked to neurotoxicity in rats (IRIS (2002)). In humans, exposure to the substance induced neurotoxicity to infants, and unrestricted use of the substance caused symptoms of the central nervous system, such as headaches, spasm and convulsions in thermal injured patients and infants. In dead infants, spongiform of the brain has been observed (IRIS (2002), HSDB (2003)). Since doses that caused neurological symptoms in dogs and rats, and the doses that caused serious neurotoxicity in humans are equivalent to the Category 1 guidance values, the substance was classified into Category 1 (nervous system).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since its 48h EC50 is 0.008mg/L for crustaceans (Daphnia magna) (AQUIRE, 2008), the substance was classified into Category 1.
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since its classification for acute toxicity is Category 1 and it is not rapidly degradable (non-biodegradable, BOD degradability: 0% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1987)), the substance was classified into Category 1.