GHS Classification Result

Chemical Name：pentachloroethane
CAS：76-01-7

Result：
ID: 20A2005
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Nonflammable (ERG (2008), Ullmanns (E) (2003))
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Nonflammable (ERG (2008), Ullmanns (E) (2003))
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing chlorine (but not fluorine or oxygen), with chlorine chemically bonded only to carbon.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Classification not possible - - - - Classification not possible due to lack of data. As relevant notes, there was no mortality at 1000mg/kg in the single dose studies using rats. However, in the 14-day repeated dose studies, 3 of 5 treated rats of both sexes died within 24 hours after the first administration (NTP TR-232 (1983)).
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Not classified - - - - Based on the negative results from both the chromosomal aberration tests using the mouse bone marrow cells and micronucleus tests (NTP DB (accessed August 2008)), the substance was classified into "Not classified". As relevant notes, positive results have been obtained from some of in vitro mutagenicity studies (gene mutation tests using mouse lymphoma cells).
6 Carcinogenicity Not classified - - - - Since it is rated Group 3 by IARC (IARC 71 (1999)), the substance was classified into "Not classified". As relevant notes, 2-year carcinogenicity studies using rats and mice that underwent oral administration resulted in no increase in tumorigenesis rates in rats, but a significant increase in frequencies of developing hepatoma in mice was reported.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects） Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Exposure to vapor of pentachloroethane induced mild narcotic effects in humans (NTP TR-232 (1983)), and pentachloroethane has a narcotic effect that has been indicated to be even greater than that of chloroform (PATTY (5th, 2001)). It may also cause drowsiness, giddiness, and unconsciousness (PATTY (5th, 2001)). As such, the substance was classified into Category 3 (narcotic effects).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In repeated dose exposure studies using rats or mice, of either 13-week (rats: 5-250mg/kg/day, mice: 5-500mg/kg/day) or 2-year duration (rats: 75-150mg/kg/day, mice: 250-500mg/kg/day) (NTP TR-232 (1983)), no serious symptoms were noted other than a significant and dose-dependent increase in diffuse inflammation of the kidney in male rats (non-neoplastic changes) in the 2-year exposure studies at the doses equivalent to Category 2 guidance values. In other studies, lesions of the kidney were reported only in male rats whose alpha2u-globlin hyaline droplets increased after administrations of pentachloroethane (IARC 71 (1999)). From these results, these observed effects are considered to be specific to male rats and not relevant to humans, as no major repeated dose toxicity was detected. However, because these studies were either carcinogenicity tests or preliminary tests to determine doses for the formal carcinogenicity tests, they do not provide appropriate and sufficient information to evaluate its repeated administration toxicity. As such, the substance was classified into "Classification not possible".
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Based on the 96-hour LC50 of 0.39mg/L for crustaceans (Mysidopsis bahia) (AQUIRE, 2008), the substance was classified into Category 1.
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since its classification for acute toxicity is Category 1 and it is not rapidly degradable (BioWin), the substance was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information