GHS Classification Result

Chemical Name：tricresyl phosphate; tritolyl phosphate
CAS：78-32-0

Result：
ID: 20A2006
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Classification not possible - - - - No data available.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Classification not possible - - - - No data available.
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on the rat LD50 > 12800mg/kg (PATTY 5th (2001)), the substance was classified into "Not classified".
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Vapours） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - According to PATTY (2001), p-isomers are reported to be not a skin irritant, but the animal species tested are just referred to as "all tested" and the details are not provided. Furthermore, according to the Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) (vol. 4), while o- and p-isomers caused moderate skin irritation to guinea pigs and m-isomers caused slight irritation, the mixture of these isomers caused no irritation (accessed in May 2008). Due to the inconsistent results documented, classification is not possible. According to classification of o-isomers, it was classified into "Not classified" because no irritation was detected (PATTY).
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - There are only in vitro data available and no in vivo data: data are insufficient.
6 Carcinogenicity Classification not possible - - - - In the 2-year oral route exposure studies in which rats and mice were exposed to a mixture of isomers (4% para-isomers), no evidence of carcinogenicity was detected (NTP No. TR433 (1994)). However, there were no data on para-isomer only, so classification is not possible.
7 Reproductive toxicity Classification not possible - - - - Since data on para-isomer itself were rare, classification is not possible.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Since no data on para-isomers were available, classification is not possible.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since its 96h-LC50 = 0.061mg/L for fish (bluegills) (EHC 110 1990), it is classified into Category 1.
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Although the substance is rapidly degradable (degradability: BOD = 100%, GC = 100%, Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1977), its classification for acute toxicity is Category 1 and it is estimated to have high potential for bioaccumulation (logPow = 6.34: calculated value, PHYSPROP Database 2008). As such, the substance was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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