GHS Classification Result

Chemical Name：2,4,6-trichlorophenol
CAS：88-06-2

Result：
ID: 20A2013
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Not classified - - - - Nonflammable (ICSC (J) (1998)).
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Nonflammable (ICSC (J) (1998)).
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen or chlorine (but not fluorine), with these elements chemically bonded only to carbon and hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the rat LD50 of 820mg/kg (EHC 93 (1989), PATTY 5th (2001)), the substance was classified into Category 4.
1 Acute toxicity （Dermal） Classification not possible - - - - Insufficient data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Results of 24-hour skin irritation tests using rabbit (Draize tests) showed that the substance was moderately irritating (IUCLID (2000)). Based on this evaluation, the substance was classified into Category 2.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Results of eye irritation tests using rabbits (Draize test) showed that the substance was highly irritating (IUCLID (2000)). Based on this evaluation, the substance was classified into Category 2A.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - Although weakly positive results were documented in mouse spot tests in which mice received intraperitoneal administration (in vivo mutagenicity studies using somatic cells) (EHC 93 (1989), ATSDR (1999), IARC 71 (1999)), these results were not dose-dependent. In addition, since the studies were evaluated as "negative" by the GENE-TOX, these results do not provide reliable evidence of positive results. In addition, although DNA damage tests by oral administration using rats showed negative results, no other proper, in vivo mutagenicity tests have been conducted. Therefore, the substance was classified into "Classification not possible" due to lack of sufficient data to justify classification into Category 2. As relevant information, in vitro studies, Ames and V79 hprt tests yielded negative results, while MLA, micronucleus and chromosomal aberration tests yielded positive results (ATSDR (1999), IARC 71 (1999)).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In 2-year oral route exposure studies using rats and mice, frequencies of developing lymphoma and leukemia increased significantly in male rats (NTP TR155 (1979)), and frequencies of developing hepatocellular carcinomas and adenoma increased significantly in male and female mice (NTP TR155 (1979)). From these results, it was concluded that the substance was carcinogenic under these study conditions. In addition, according to IARC, some evidence of carcinogenicity was detected in animal experiments and the substance was classified into Group 2B based on the results obtained from exposure to polychlorinated phenol complex or its sodium salts (IARC 71 (1999)). In addition, EPA has classified the substance into Group B2 (IRIS (2002)). Based on these evaluations by IARC and EPA, the substance was classified into Category 2. In epidemiological research on soft tissue sarcoma and non-Hodgkin's lymphoma in humans (IARC 71 (1999)), causal relationships between exposure to this substance and tumorigenesis were unclear.
7 Reproductive toxicity Classification not possible - - - - Male rats that had been exposed to the substance via oral route for 11 weeks were mated with non-exposed females, and the females that became pregnant were examined 18 days after the mating; there were no adverse effects observed on sexual functions in parental animals, fertility, or development of fetuses (EHC 93 (1989)). However, this study was not conducted in compliance with the standardized protocol of reproductive studies, and provides insufficient data on teratogenicity including effects on development of fetuses. As such, classification is not possible.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Insufficient data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In the 90-day oral administration studies using rats, NOAEL was 80mg/kg/day and LOAEL was 240mg/kg/day based on increased weight and change in clinical test values of the liver that was examined as a target organ (Bercz JP, et al. 1990. Subchronic toxicity studies of 2,4,6-trichlorophenol in Sprague-Dawley rats. Journal of the American College of Toxicology 9(5): 497-506). Observed weight changes of the liver and adrenal gland at the administration dose of 240mg were not considered to be pathological changes. Since changes in ALT occurred at 720mg, the dose of 240mg is not considered to have any effects. Furthermore, other studies, including 2-year carcinogenicity tests by oral administration (mixed diet) using rats or mice, and 7-week oral administration tests which were conducted to determine doses to use in the former test mentioned above, were reported. In these studies, no general toxicity was detected other than moderate to marked increase in splenic hematopoiesis and midzonal vacuolation of hepatocytes in rats after administration of 4600 ppm (2300mg/kg/day) for 7 weeks, and leukocytosis and monocytosis in a 2-year test (NTP TR-155 (1979)). Also, no other studies (IARC vol. 71 (1999)) have reported clear effects of the administration other than changes in weights of organs. Overall, although these results indicate "Not classified" (oral), no severe toxic effects were observed at the guidance doses, and data on other routes of exposure are lacking. Thus, the substance was classified into the "Classification not possible" category.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since its 96-hour LC50 is 0.61mg/L in fish (guppies) (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) (vol. 2), 2003), the substance was classified into Category 1.
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Its classification for acute toxicity is Category 1, it is rapidly degradable (BOD degradability: 82.5%, Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1978), and its potential for bioaccumulation is estimated to be low (log Kow = 3.69 (SRC, 2005)). Thus, the substance was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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