NITE - Chemical Management Field

GHS Classification Result

Chemical Name：biphenyl-2-ol; 2-hydroxybiphenyl; 2-phenylphenol (ISO)
CAS：90-43-7

Result：


ID:	20A2016
Classifier:	Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified:	FY2008
Reference Manual:	GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	-	-	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	-	-	-	-	Solid (GHS definition)
7	Flammable solid	Classification not possible	-	-	-	-	No data available.
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	-	-	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	-	-	-	-	Since its autoignition point is approx. over 70degC, the substance does not ignite spontaneously at room temperature.
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to solid (melting point <= 140degC) substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	-	-	-	-	Solid (GHS definition)
14	Oxidizing solids	Not applicable	-	-	-	-	The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no bivalent -O-O- structure
16	Corrosive to metals	Classification not possible	-	-	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Based on the rat oral LD50 values of 2800mg/kg (DFGOT (1991)), 2600-2800mg/kg (PATTY 5th, (2001)), and 3000mg/kg (IARC (1989)), the substance was classified into "Not classified" using JIS classification criteria (Category 5 in UN classification).
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on the rabbit dermal LD50 > 5000mg/kg (PATTY 5th, (2001)), the substance was classified into "Not classified".
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	Its 4-hour or 4-hour-corrected LC50 values have been documented to be > 0.24mg/L (IUCLID (2000)). However, since these values did not provide a basis for classification, classification is not possible.
2	Skin corrosion/irritation	Category 2		Warning	H315: Causes skin irritation	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse.	Results of rabbit tests (complying with OECD guidelines 404) (IUCLID (2000)) showed that the substance was slightly to highly irritating. Based on the information, the substance was classified into Category 2. As relevant notes, no irritation was observed in humans and rabbits when a 0.1% aqueous solution of this substance was applied to skin for 24 hours (DFGOT (1991)).
3	Serious eye damage/eye irritation	Category 2A		Warning	H319: Causes serious eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection.	Results of rabbit tests (IUCLID (2000)) showed that the substance was moderately to highly irritating. Based on the information, the substance was classified into Category 2A.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Not classified	-	-	-	-	No signs of skin sensitization were observed in either maximization tests or Buehler tests using guinea pigs (IUCLID (2000)), (PATTY 5th, (2001)). No sensitization was also observed in human tests involving 200 people (PATTY 5th, (2001)). Based on these results, the substance was classified into "Not classified". As relevant notes, a positive reaction was observed in 7 out of 588 persons to whom a 1% solution of this substance in petrolatum was applied. However, the severity of the reaction was not described in the literature. In addition, two cases of severe contact dermatitis through occupational exposure were described in the literature, which the author put down to the effects of this substance in hand cream and in metal-working fluids (DFGOT (1991)).
5	Germ cell mutagenicity	Not classified	-	-	-	-	The substance was classified into "Not classified" based on negative results obtained in both dominant lethal tests using mice (in vivo heritable mutagenicity tests) and chromosomal aberration tests using rat bone marrow cells (IARC (1999) vol. 73, IARC (1983) vol. 30). In addition, negative results have been obtained from oral administration in chromosomal aberration tests using rat bone marrow cells (IARC (1999) vol. 73).
6	Carcinogenicity	Not classified	-	-	-	-	Based on Group 3 classification by IARC, the substance was classified into "Not classified". As relevant information, in the studies in which rats and mice were fed a diet containing the substance for 2 years, structural alterations in the kidney and urinary bladder, including urothelial hyperplasia and neoplasia (papilloma and transitional cell carcinoma), were observed in rats; and increased incidence of liver adenomas cases were observed in mice. However, these incidences of neoplasms were seen only in males given mid-doses or higher (PATTY 5th, (2001)).
7	Reproductive toxicity	Not classified	-	-	-	-	In the 2-generation reproduction tests using rats, there were no effects on reproduction or development at the doses that cause general toxicity such as decreased body weight gain in parental animals and histological changes in the kidney and urinary bladder (PATTY 5th, (2001)). In other studies involving rats, rabbits and mice that were exposed during the organogenetic period, the substance had no adverse effects such as teratogenic effects in the offspring, although in parental animals, decreased body weight gain, mortality, and pathological changes in the kidney and liver were observed at high dosages in all species tested (IARC (1999) vol. 73, PATTY 5th, (2001), CERI hazard data 5th (2007)). From these results, the substance was classified into "Not classified". As additional notes, increased incidences of embryo resorption by exposure to this substance during the organogenetic period were documented. However, since this symptom was observed only in one of two rat studies conducted, the result may be accidental.
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	No data available.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	In 3-month oral exposure studies using rats, pathological changes were observed in the kidney at 1000-1500mg/kg/day. However, in other rat oral exposure studies of 3-month and 6-month durations, no pathological changes were observed at 500-1000mg/kg/day (DFGOT (1991)). In two other rat studies performing 12 or 13-week oral route exposure, NOAEL were reported to be >= 420mg/kg/day and >= 780mg/kg/day (PATTY 5th (2001)). On the other hand, in 2-year oral route exposure studies with mice, decreased body weight gain and histological changes in livers were observed at >= 250mg/kg/day, and NOEL was indicated to be 100mg/kg/day (PATTY 5th (2001)). There are no studies on humans, and toxicity to organs observed in animal tests was associated only with administration doses higher than the guidance values. Although these results suggested that the substance falls into "Not classified" (oral), there were no data on other routes available. Thus, the substance was classified into "Classification not possible".
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Based on its 48-hour LC50 of 0.71mg/L for crustaceans (Daphnia magna) (AQUIRE, 2008), the substance was classified into Category 1.
11	Hazardous to the aquatic environment （Long-term）	Not classified	-	-	-	-	Its classification for acute toxicity is Category 1, it is rapidly degradable (BOD degradability: 47-86% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1980)), and its potential for bioaccumulation is estimated to be low (log Kow = 3.09 (SRC, 2005)). Based on the information, the substance was classified into "Not classified".

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）