Chemical Name：6-phenyl-1,3,5-triazine-2,4-diyldiamine; 6-phenyl-1,3,5-triazine-2,4-diamine; benzoguanamine
CAS：91-76-9

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 4		Warning	H302: Harmful if swallowed	P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ...	Since the rat LD50 = 933mg/kg (SIDS (2001)), the substance was classified into Category 4.
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Category 4		Warning	H332: Harmful if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell.	Since its rat LC50 = 2.932mg/L (SIDS (2001)), the substance was classified into Category 4. It was assumed that the test was performed with dust (mist) since its saturated vapor pressure concentration is 75.8 * 10E-7mg/L.
2	Skin corrosion/irritation	Not classified	-	-	-	-	In rabbit irritation tests (SIDS (2001)), the substance was found to be not irritating. Based on this result, the substance was classified into "Not classified".
3	Serious eye damage/eye irritation	Category 2B	-	Warning	H320: Causes eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling.	In eye irritation tests using rabbits (SIDS (2001)), the substance was found to be mildly irritating. Thus, the substance was classified into Category 2B.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	No data available.
5	Germ cell mutagenicity	Not classified	-	-	-	-	Based on negative results obtained from mouse micronucleus tests (in vivo mutagenicity tests using somatic cells), the substance was classified into "Not classified". Among in vitro mutagenicity tests conducted, Ames tests yielded negative results while chromosomal aberration tests yielded both positive and negative results.
6	Carcinogenicity	Classification not possible	-	-	-	-	Negative results were documented from 18-month oral administration studies using mice and rats (SIDS (2001)). However, the test protocol used was not appropriate compared with the current updated test guidelines, and the data were inadequate for the evaluation of carcinogenicity (SIDS (2001)). Therefore, classification is not possible.
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	In combined studies on repeated oral toxicity tests and reproductive and developmental toxicity tests using rats (complied with OECD TG 422 GLP), effects of the substance were not observed on reproductive functions of parental animals in terms of estrous cycles, mating ratio, fertilization rates, number of days required for mating, number of corpora lutea or number of implantation sites. Also, no effects on gestational period, litter size or birth rate were observed. On the other hand, inferior nursing behavior by maternal animals was observed immediately after parturition as well as during the nursing period in terms of collecting, lactating, and warming their pups (newborns). These observations suggest that the administration of this substance during the perinatal period may affect parturition and nursing behavior. Increased fetal death rates and accompanying decreased birth rates as a result of inferior nursing behavior by maternal animals were observed. Also, since decreased survival rates of 4-day old neonates, lower body weight of neonates (both sexes) at birth, and decreased body weight gain after 4 days of nursing were observed, effects of the substance on the development of the fetus and offspring during prenatal and nursing periods were indicated (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council), accessed in May 2008). From these results, the substance was classified into Category 2.
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	No data available.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	In 90-day repeated oral administration tests using rats (complied with OECD TG 408 GLP), NOAEL was 19mg/kg/day. There is a description that the following symptoms were observed at 173mg/kg/day in histopathological studies (SIDS (2001)): in blood chemistry, increases in plasma alanine aminotransferase and bilirubin; in the histopathology, centrilobular hepatocyte enlargement, an increased severity of splenic extramedullary hemopoiesis, hypertrophy and vacuolation of adrenal zona glomerulosa cells, and degeneration of pancreatic exocrine cells together with associated inflammatory cell infiltrates were shown; an increased severity and/or incidence of hemosiderin pigment accumulation. Since the dose used in these studies exceeds Category 2 guidance values, "Not classified" is normally the appropriate classification. However, because the studies did not include doses that are close to the upper limit of Category 2 guidance values, this classification leaves some uncertainty. Furthermore, there are no data on dermal or inhalation route exposure, and thus, in conclusion, classification is not possible.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.