GHS Classification Result

Chemical Name：3,4-dichloroaniline
CAS：95-76-1

Result：
ID: 20A2024
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Classification not possible - - - - NFPA (13th, 2006) classification is 1, and it is considered as an ordinary flammable substance. However, according to ERG (2008), it is not readily combustible, and thus classification is not possible.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Its autoignition point is >= 260degC (ICSC (2000), NFPA (13th, 2006)), and thus is >= 70degC.
11 Self-heating substances and mixtures Classification not possible - - - - Its melting point is 72degC (Ullmanns (6th, 2003), Chapman (ver.16.1, 2008), HODOC (3rd, 1997), Lide (88th, 2008), ICSC (2000), NFPA (13th, 2006)). Test methods applicable to solid (melting point <= 140degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing chlorine, which is chemically bonded only to carbon.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - Its melting point is 72degC (Ullmanns (6th, 2003), Chapman (ver.16.1, 2008), HODOC (3rd, 1997), Lide (88th, 2008), ICSC (2000), NFPA (13th, 2006)). Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the rat LD50 values (male: 570, 880, 510 and 545mg/kg bw; female: 530 and 470mg/kg bw) (EU-RAR (65, 2006), PATTY (5th, 2001)), the substance was classified into Category 4.
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Of the rabbit LD50 of 300 and 631mg/kg bw (EU-RAR 65, 2006) documented, the value of 300mg/kg bw, which represents higher toxicity, was used as the basis to classify the substance into Category 3.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Of its rat LC50 values of 3.3mg/L and 0.631mg/L obtained from 4-hour aerosol exposure tests (EU-RAR (65, 2006)), the value of 0.631, which represents higher toxicity, was used as the basis to classify the substance into Category 3.
2 Skin corrosion/irritation Not classified - - - - In Draize tests using rabbits, erythema of Grade 1 were observed, but the symptom was reversibly recoverable in 2 days and no edemas were detected (EU-RAR 65, 2006). Thus, the substance was classified into "Not classified".
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		In Draize tests using rabbits, moderate irritation to the conjunctivas and irises were observed. Although these symptoms disappeared after 14 days, angiogenesis of the cornea started in 7 days and was seen even after 14 days in 2 of 3 rabbits (EU-RAR65, 2006). Since the recovery took 14 days, the substance was classified into Category 2A.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on positive results (irritating) from skin sensitization tests using guinea pigs (maximization tests) (EU-RAR (65, 2006)), the substance was classified into Category 1.
5 Germ cell mutagenicity Not classified - - - - Mouse micronucleus tests via oral and intraperitoneal administration using the bone marrow cells (in vivo mutagenicity tests) yielded negative results (EU-RAR (65, 2006)). Based on these results, the substance was classified into "Not classified". In addition, in vitro mutagenicity tests (both Ames tests and chromosomal aberration tests using human lymphocytes) yielded negative results (EU-RAR 65 (2006)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - In oral administration tests using pregnant rats (EU-RAR (65, 2006)), no adverse effects on embryos or fetuses were observed. However, since no data are available on reproductive toxicity of parental animals, classification is not possible.
8 Specific target organ toxicity - Single exposure Category 2 (nervous system, blood system) Warning H371: May cause damage to organs (nervous system, blood system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In oral administration tests using rats, paralysis of hind legs was observed at 500-800mg/kg. In 24-hour dermal administration tests using rats, cyanosis was observed in all dose groups, and in 4-hour mist inhalation tests (saturated vapor pressure = 0.055mg/L), high values of methemoglobin were detected at 2.8mg/L (EU-RAR (65, 2006)). From these results, the substance was classified into Category 2 (nervous system, blood system).
9 Specific target organ toxicity - Repeated exposure Category 1 (blood system) Danger H372: Cause damage to organs through prolonged or repeated exposure (blood system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In 2-week inhalation tests using rats (treated 6 hours a day, 5 days a week), high values of methemoglobin and the deposition of hemosiderin onto the spleen (45mg/m3, 90-day conversion: 0.007mg/L) were observed. Also, in 6-month oral administration tests with rats, high values of methemoglobin were documented at the dose of 20mg/kg, equivalent to the Category 2 guidance doses (EU-RAR 65, 2006). Based on the results of 2-week inhalation tests, the substance was classified into Category 1 (blood system).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since 48-hour EC50 = 0.55mg/L for crustaceans (Daphnia magna) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 1995), the substance was classified into Category 1.
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since its classification for acute toxicity is Category 1 and it is not rapidly degradable (non-biodegradable, BOD degradability: 0% (data from Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1979)), the substance was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information