GHS Classification Result

Chemical Name：2,4,5-trichlorophenol
CAS：95-95-4

Result：
ID: 20A2025
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Not classified - - - - It is documented to be not flammable (Weiss, 1986).
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - It is documented to be not flammable (Weiss, 1986).
11 Self-heating substances and mixtures Not classified - - - - It is documented to be not flammable (Weiss, 1986).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing chlorine (but not fluorine or oxygen), with chlorine chemically bonded only to carbon and hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on the rat LD50 values of 820mg/kg (EHC 93, 1979), 2460-2960mg/kg (EHC 93, 1979, DFGOT vol. 12, 1999), > 2500mg/kg (DFGOT vol. 12, 1999), and 2960mg/kg (DFGOT vol. 12, 1999, IARC 20, 1979), the substance was classified into "Not classified" (Category 5 in the UN classification).
1 Acute toxicity （Dermal） Classification not possible - - - - Since the rat LD50 is >= 1000mg/kg (DFGOT vol. 12 (1999)), classification is not possible.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		In rabbit studies, mild to severe cases of erythema were observed, and thus the substance was evaluated as mildly to severely irritating (EHC (1999), DFGOT vol. 12 (1999)). In addition, one human case of erythema, edema, and severe corrosion has been reported, although exposure doses were unspecified (DFGOT vol. 12 (1999)). Taking the EU's R36/38 classification (EU-Annex 1 (accessed in July 2008)) into account, the substance was classified into Category 2.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		In rabbit studies, erythema, edema, and slight corneal clouding were observed, and these symptoms did not regress after 7 days (DFGOT vol. 12, 1999). In addition, the EU's classification of the substance is R36/38. From the information, the substance was classified into Category 2A.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - The positive results obtained in a modified lymph node test using mice can probably be attributed to the irritating effects of the substance (DFGOT vol. 12 (1999)). In humans, sensitization was not observed after long-term application of the substance to 200 chemical factory workers (DFGOT vol. 12, 1999). However, since these observations do not exclude the possibility of skin sensitization with certainty, classification is not possible.
5 Germ cell mutagenicity Classification not possible - - - - Negative results were obtained from both sister chromatid exchange tests using the substance-exposed human lymphocytes and chromosomal aberration tests (IARC vol. 71, 1999, DFGOT vol. 12, 1999). However, exposure doses were unspecified (IARC vol. 71, 1999, DFGOT vol. 12, 1999). Since there are no other adequate data available from in vivo mutagenicity tests, the substance was classified into "classification not possible". As relevant notes, positive results have been obtained from in vitro mutagenicity tests (Ames tests (IARC 71 (1999)) and chromosomal aberration tests using CHO and CHL cells (IARC 71 (1999), DFGOT 19 (1991)).
6 Carcinogenicity Classification not possible - - - - Signs of carcinogenicity have been seen in workers employed in factories producing 2,4,5-trichlorophenol (IARC vol. 71, 1999, EHC, 1989). However, it cannot be determined whether the cancer was linked to this substance or other substances handled in the manufacturing process (IARC vol. 71, 1999). According to the IARC (vol. 71, 1999), "There is limited evidence in humans for the carcinogenicity of combined exposures to polychlorophenols. There is inadequate evidence in experimental animals for the carcinogenicity of 2,4,5-trichlorophenol". Therefore, the substance was classified into "Classification not possible".
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In the studies using mice (DFGOT, 1999, HSDB, 2003, BUA, 1992), a slight increase in mortality of the offspring before birth is documented, and in EHC 93i (1989), toxic effects on the offspring or fetuses are documented. Thus, the substance was classified into Category 2.
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation, Narcotic effects） Warning H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects)
H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects) 		P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Although there are reported human cases involving chloracne (EHC, 1989), the effects of the impurity 2,3,7,8-tetrachlorodibenzo-p-dioxin, could not be excluded, and thus evaluation is not possible. The studies using rats, mice, rabbits, guinea pigs, and cats (DFGOT vol. 12, 1999) documented symptoms such as labored breathing, narcotic effects, and irritation of the mucous membranes. Thus, the substance was classified into Category 3 (respiratory tract irritation, narcotic effects).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Although human cases involving porphyria and chloracne have been documented, the effects of the impurity, 2,3,7,8-tetrachlorodibenzo-p-dioxin, could not be excluded. Thus evaluation is not possible (DFGOT vol. 12, 1999).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since 48-hour EC50 = 0.98mg/L for crustaceans (Daphnia magna) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 2002), the substance was classified into Category 1.
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since its classification for acute toxicity is Category 1 and it is not rapidly degradable (non-biodegradable, BOD degradability: 0% (data from Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1979)), the substance was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information