GHS Classification Result

Chemical Name:anilazine (ISO); 2-chloro-N-(4,6-dichloro-1,3,5-triazin-2-yl)aniline
CAS:101-05-3

Result:
ID: 20A2029
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance contains chlorine (but not fluorine or oxygen) and is chemically bonded only to carbon.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Since the rat LD50 = 2700mg/kg (HSDB (2003)), the substance was classified into "Not classified" using JIS classification criteria (Category 5 in the United Nations classification).
1 Acute toxicity (Dermal) Not classified - - - - Based on the rat LD50 > 5000mg/kg (IUCLID (2003), HSDB (2003)), the substance was classified into "Not classified".
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Since its rat LC50 = ca. 0.25mg/L/4hr (IUCLID (2003)), the substance was classified into Category 2.
2 Skin corrosion/irritation Classification not possible - - - - Rabbit studies documented that the substance was not irritating (IUCLID (2003)) or was a mild skin irritant (HSDB (2003)), and there is a description that "This product dyrene has caused skin irritation in exposed workers." (HSDB (2003)). However, since there were some inconsistencies in the descriptions, classification is not possible.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
Since rabbit studies indicated that the substance was a severe eye irritant (HSDB (2003)) and was highly irritating (IUCLID (2003)), it was classified into Category 2A.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - In guinea pig studies, other than positive reactions of skin sensitization documented, detailed data were not provided (IUCLID (2003)). In addition, although positive reactions were detected by patch tests in 6 out of 7 people being exposed to the substance (IUCLID (2003)), no positive reactions were detected in challenge tests involving 3 farm workers. In addition, results indicated that anilazine was not highly sensitizing, if at all in patch tests involving 39 female farm workers (HSDB (2003)). Overall, since there were significant inconsistencies present in the documented information, the substance was classified into "Classification not possible".
5 Germ cell mutagenicity Classification not possible - - - - Because no in vivo tests had been conducted, classification is not possible. As relevant notes, in vitro mutagenicity tests (mouse lymphoma tests) resulted in positive reactions, but Ames tests and chromosomal aberration tests resulted in negative reactions (NTP, 1978).
6 Carcinogenicity Not classified - - - - In carcinogenicity tests in which rats and mice underwent oral route exposure for 2 years, frequencies of tumorigenesis did not increase (NTP (1979)). Though not previously classified, the substance has been concluded to be non-carcinogenic to rats and mice (NTP (1978)). Thus, the substance was classified into "Not classified".
7 Reproductive toxicity Not classified - - - - In reproductive toxicity tests in which 3 generations of rats underwent oral route exposure, there were no adverse effects on reproductive functions or development. Similarly, in oral route exposure tests using rats and rabbits during gestational periods, no fetal toxicity or teratogenicity was observed. Thus, the substance was classified into "Not classified".
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In preliminary tests, which were conducted to establish doses to use in separate 2-year studies, rats and mice were fed a diet containing the substance at 250-16000 ppm for 13 weeks; no major toxicity was observed (NTP (1978)). Similarly, in long-term repeated administration tests with rats, mice, and dogs, no clear cases of toxic symptoms were observed (NTP (1978)), with NOEL for rats, mice, and dogs 2000mg/kg, 1250mg/kg, and 40mg/kg, respectively (HSDB (2003)). However, the 13-week studies were not conducted under appropriate testing conditions, and other long-term studies did not provide detailed information. Thus, classification was not possible.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since its 96-hour LC50 = 0.14mg/L for fish (rainbow trout) (ECOTOX, 2008), the substance was classified into Category 1.
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since its classification for acute toxicity is Category 1 and it is not rapidly degradable (SRC: BioWin V4.10), the substance was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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