GHS Classification Result

Chemical Name：dicyclohexylamine
CAS：101-83-7

Result：
ID: 20A2032
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Since its flash point is 105degC (Ullmanns (E) (2003)), the substance was classified into "Not classified".
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Since its autoignition point is 240degC (Ullmanns (E) (2003)), the substance was classified into "Not classified".
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Classification not possible - - - - No data available.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Among documented rat LD50 values of 373mg/kg (PATTY (5th, 2001)), 200mg/kg (IUCLID (2000)), 240mg/kg (ca.) (HSDB (2003)), and 500mg/kg (IUCLID (2000)), the value representing the highest hazard was used as the basis to classify the substance into Category 3.
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rabbit LD50 of 316mg/kg (PATTY (5th, 2001)) and 200-316mg/kg (HSDB (2003)), the substance was classified into Category 3.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on the rat LD50 of > 1.4mg/L in 6-hour tests (4-hour conversion LC50: 2.1mg/kg), (IUCLID (2000)), the substance was classified into Category 4. Because its toxic concentration is higher than 90% (40 ppmV) of saturated vapour pressure concentration (188.7 ppmV), we judged that the substance was mist.
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In primary skin irritation tests, the substance was topically applied onto 6 rabbits for 24 hours, and during the 21-day observation, the average scores of the Primary Dermal Irritation Index after 24-72 hours indicated that the substance was corrosive (HSDB (2003)). Other tests also reported that the substance was highly corrosive (IUCLID (2000)) or causes immediate necrosis (IUCLID (2000)). Thus, the substance was classified into Category 1.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Its preexisting classification for skin corrosion is Category 1.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - No in vivo data are available and thus classification is not possible. Among in vitro mutagenicity tests, negative results were documented from both chromosomal aberration tests using cultured mammalian cells and gene mutation tests using microorganisms.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In oral administration tests, rats were administered at 80mg/kg, a dose that induces general toxicity such as decreased body weight gain and decreased food consumption in parental rats (both sexes). This administration resulted in severely decreased survival rates in neonates, unkempt fur and neglected brood collection during nurturing periods (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council)), (accessed June 2008). From these results, the substance was classified into Category 2. Although 2 of the 12 treated female rats died after 21-22 days of gestation, the dose that induced developmental toxicity (80mg/kg) was lower than the rat oral LD50 values (200mg/kg (IUCLID (2000)) and 240mg/kg (ca.) (HSDB (2003)).
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Category 2 (nervous system) Warning H373: May cause damage to organs through prolonged or repeated exposure (nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In 28-day repeated oral administration tests, rats administered at 70mg/kg showed salivation and convulsions under normal conditions, suggesting that the substance has toxicological effects on the autonomic nervous system. The no-observed effect level has been documented to be 20mg/kg for both sexes (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council) (2008)). Since the 90-day conversion of the NOEL 20mg/kg is 64mg/kg, which is equivalent to Category 2 guidance values, the substance was classified into Category 2 (nervous system).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Since its 48-hour EC50 = 8.0mg/L for crustaceans (Daphnia magna) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 1998), the substance was classified into Category 2.
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Its classification for acute toxicity is Category 2, it is rapidly degradable (BOD degradability using 2-week standard methods: 76.9% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1977)), and it is estimated to be prone to bioaccumulation (log Kow = 4.4 (> 4.0, (PHYSPROP database, 2008)). Based on this information, the substance was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information