GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：succinic anhydride
CAS：108-30-5
Result：
| ID: | 20A2039 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2008 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （Sep, 2008） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 7 | Flammable solid | Classification not possible | - | - | - | - | No data available. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 10 | Pyrophoric solids | Classification not possible | - | - | - | - | No data available. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | No data available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 4 |
|
Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
The rat LD50 data are available for both sexes, with 1510mg/kg for females and 2160mg/kg for males (NTP TR373 (1990)). Using the lower value of the two (females), the substance was classified into Category 4. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | Although it is documented that the substance is a skin irritant (HSDB (2006)), the data are insufficient. |
| 3 | Serious eye damage/eye irritation | Category 1 |
|
Danger | H318: Causes serious eye damage |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. |
Applications of the substance to the eyes of rabbits resulted in necrosis of 75% of corneas tested, 18-24 hours after application. From these results, the substance has been classified into Grade 8 (Grade 10 is the maximum) (NTP TR373 (1990)). Based on this information, the substance was classified into Category 1. In addition, the EU has classified it into Xi; R36/37. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | Although IgG antibody measurement tests showed low levels of antibody production 21 days after subcutaneous injections (HSDB (2006)), data were insufficient. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | Based on negative results obtained from in vivo mutagenicity tests using somatic cells (chromosomal aberration tests using the rat bone marrow cells) (NTP TR373 (1990)), the substance was classified into "Not classified". Among in vitro tests, negative results were reported from Ames tests, chromosomal aberration tests (ovarian cells, pneumocytes, and lung fibroblasts of Chinese hamsters), and tests using mouse lymphoma cells L5178Y (NTY TR373 (1990)). |
| 6 | Carcinogenicity | Not classified | - | - | - | - | In 2-year oral administration tests using rats or mice, no evidence of carcinogenicity was obtained from both animal species (NTP TR373 (1990)). In addition, the substance has been classified into Group 3 by IARC. Based on this information, the substance was classified into "Not classified". |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | Intraperitoneal injection at 50mg/kg into mice that had been pregnant for 8-10 day resulted in branched ribs, fused vertebrae, or cleft palate in 23% of surviving offspring (NTP TR373 (1990)). Intraperitoneal injections at 0.25mmol/L via into mice that had been pregnant for 11-13 days resulted in significant increase in defects in fetuses. Intraperitoneal injections of succinic anhydride induce malformations in mice at doses nearly lethal to adults (NTP TR373 (1990)). Since the only data available were those of intraperitoneal injection, classification is not possible. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | No data available. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | Rat or mouse tests have been conducted in which oral administration was repeated for 13 weeks or 2 years (NTP TR373 (1990). In the 13-week administration tests, mortality occurred at high doses in both rats and mice, but at lower doses (100mg/kg/day for rats and 150mg/kg/day for mice), no specific findings were noted in clinical observations, autopsy, and histopathological examinations other than lowered average body weight and gastritis in male mice which seemed to be a localized effect (NTP TR373 (1990)). Furthermore, in the 2-year administration tests, in which highest doses administered were 100mg/kg/day for rats and 75 (males) to 150mg/kg/day (females) for mice, decreased average body weight was detected. However, these doses did not affect survival rates compared with that of the control groups and in the case of males, survival rates of treated mice significantly increased. In addition, histopathologically speaking, frequencies of neoplastic lesions or non-neoplastic lesions did not increase regardless of administration of this substance (NTP TR373 (1990)). These results show that no severe toxic effects were observed with dosages that are equivalent to the upper limit of the guidance values in either rat or mouse repeated oral administration tests for 13 weeks or 2 years, and therefore the substance should be classified into the "Not classified" category. However, due to lack of data on other administration routes, it was classified into the "Classification not possible" category in conclusion. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Not classified | - | - | - | - | Although there are no data available on this substance, this substance is thought to be prone to rapid hydrolysis producing succinic acid. Since the 48h-EC50 of succinic acid (CAS: 110-15-6) is 374.2mg/L for crustaceans (Daphnia magna) (HSDB, 2005), the substance was classified into "Not classified". |
| 11 | Hazardous to the aquatic environment （Long-term） | Not classified | - | - | - | - | Since its classification for acute toxicity is "Not classified" and it is water soluble (water solubility = 23.76g/L (PHYSPROP database, 2008)), the substance was classified into "Not classified". |
NOTE:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
|
Reference Manual |
|
|
Definitions / Abbreviations |
|
|
Model Label by MHLW |
MHLW Website （in Japanese Only） |
|
Model SDS by MHLW |
MHLW Website （in Japanese Only） |