GHS Classification Result

Chemical Name:bis(2-methoxyethyl) ether
CAS:111-96-6

Result:
ID: 20A2044
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Based on its flash point of 56degC (closed cup) (Solvents Handbook, Ohmsha Ltd. (1994)), the substance was classified into Category 3 (flash point between 23degC and 60degC).
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Its autoignition point is 240degC (Solvents Handbook, Ohmsha Ltd. (1994)), which is above 70degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - The LD50 values of 5000mg/kg (ECETOC TR94 (1995)) and 4760mg/kg bw (CICADs 41 (2002)) are equivalent to "Not classified", based on JIS classification criteria (Category 5 in the United Nations classification).
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Not classified - - - - The rat LD50 of 24mg/L/4h (CICADs 41 (2002)) is equivalent to the "Not classified" category. Since saturated vapor concentration is 21.4mg/L, the tests were thought to be conducted with mist.
2 Skin corrosion/irritation Not classified - - - - In rabbit tests (US FDA TG), slight irritation was detected within 24 hours at the application dose of 0.5ml (CICADs 41 (2002)). Other rabbit tests concluded that the substance was not irritating (ECETOC TR94 (1995)). From these data, the substance was judged to be slightly irritating, and it was classified into "Not classified" based on the JIS classification criteria (Category 3 in the United Nations classification).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
In rabbit tests (US FDA TG), slight irritation was detected within 24 hours at the application dose of 0.1ml (CICADs 41 (2002)). Other rabbit tests concluded that the substance was not irritating (ECETOC TR94 (1995)). From these results, the substance was evaluated to be slightly irritating, and it was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Not classified - - - - Buehler tests using guinea pigs and alternative footpad methods revealed that the substance was not sensitizing (ECETOC TR95 (2005); ECETOC TR95 (2005)). Based on these results, the substance was classified into "Not classified".
5 Germ cell mutagenicity Not classified - - - - In dominant lethal tests performing inhalation exposure to rats (in vivo heritable mutagenicity tests), decreased number of pregnant animals and loss of pre-implantation embryos were observed, but these effects were thought to be caused by lowered fertility (CICADs No. 41 (2002)). In addition, negative results were obtained from chromosomal aberration tests using the bone marrow cells of rats that underwent inhalation exposure (in vivo mutagenicity tests using somatic cells) (CICADs No. 41 (2002)). From these results, the substance was classified into "Not classified". Among in vitro mutagenicity tests, negative results were obtained from Ames tests (CICADs No. 41 (2002)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
In reproductive toxicity tests using male rats that underwent inhalation exposure, fertilization rates decreased (ECETOC TR No. 17 (1985)); and in developmental toxicity tests using rats that underwent inhalation exposure during the organogenetic period, malformation of the offspring occurred at low rates and embryo resorption increased (100% at 400ppm) (CICADs 41 (2002)). In developmental toxicity tests using mice that underwent oral administration during the organogenetic period, malformation of digits and limbs (ECETOC TR95 (2005)), cerebral prolapse, and malformation of bones (Birth defects (3rd, 2007)) were observed at the doses that caused mortality of parental animals. Similarly, in reproductive toxicity tests using rabbits, resorption of fetuses and malformation of bones were observed at the doses that caused mortality of parental animals (CICADs 41 (2002)). Based on these results, the substance was classified into Category 2.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Although symptoms such as irregular breathing were observed in rats that underwent inhalation exposure (10mg/L/7h) (CICADs 41 (2002)), classification is not possible due to lack of other data.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In 2-week inhalation exposure tests using rats (0.614, 2.06, and 61.4mg/L/6h), changes in the bone marrow, pancreas, thymus, leukocytes, and erythrocytes were observed in both sexes at 61.4mg/L (90-day conversion: 9.6mg/L/6h) which exceeds Category 2 guidance values (CICADs 41 (2002)). In addition, in 3-week inhalation exposure tests using rats (1.12 and 3.35mg/L/6h), atrophy of thymus glands and blood congestion in adrenal glands were observed at 3.35mg/L (90-day equivalent: 0.84mg/L), a dose that is equivalent to the Category 2 guidance values (CICADs 41 (2002)). However, in both studies, severity of the symptoms was not provided. Since no other data are available, classification is not possible. As relevant background notes, decreased weights of the testis, epididymis, seminal vesicles, and prostate gland were observed in male rats (CICADs 41 (2002)).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - Since its 48-hour EC0 is > 1000mg/L for crustaceans (Daphnia magna) and its 96-hour LC0 is > 2000mg/L (CICAD, 2000) for fish (golden orfe), with both values exceeding 100mg/L, the substance was classified into "Not classified".
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since it is water soluble (water solubility: 1000000mg/L (SRC, 2005)) and its classification for acute toxicity is "Not classified", the substance was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


To GHS Information