GHS Classification Result

Chemical Name:2-(2-butoxyethoxy)ethanol; diethylene glycol monobutyl ether
CAS:112-34-5

Result:
ID: 20A2047
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Its flash point is 78degC (closed cup, Weiss (2nd, 1986)), which is between 60 and 93degC.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Its autoignition point is 223-228degC (Ullmanns (E) (6th, 2003)).
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Several rat LD50 values were obtained from the List 1 source (6560, 5660, 7300, 9600, 6530, and 5080mg/kg) (DFGOT vol. 7 (1992), ECETOC TR. 64 (1995), PATTY (5th, 2001)). Since all values exceed 5000mg/kg, the substance was classified into "Not classified".
1 Acute toxicity (Dermal) Not classified - - - - Based on the rat LD50 values obtained from the List 1 source (> 2000mg/kg) (DFGOT vol. 7 (1992)) and the rabbit LD50 values (2764 and 4120mg/kg) (PATTY (5th, 2001), EU-RAR (2007)), the substance was classified into "Not classified" using JIS classification criteria (Category 5 in the United Nations classification).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Although rats being exposed to 18ppm for 7 hours did not cause mortality (EU-RAR (2007)), classification is not possible due to lack of other data.
2 Skin corrosion/irritation Not classified - - - - In rabbit tests, the substance was determined to be not irritating or slightly irritating (IUCLID (2000), BUA (1997), HSDB (2007)), and patch tests in humans resulted in only few people with erythema (DFGOT vol. 7 (1992), ECETOC TR 64 (1995), HSDB (2007)). From these results, the substance was classified into "Not classified" using JIS classification criteria (Category 3 in the United Nations classification).
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
In tests in which the substance was applied into rabbits' eyes, moderate irritation and tissue damage were observed, but they disappeared within 14 days (ECETOC TR 64 (1995), PATTY (5th, 2001)). In other tests, the substance was documented to be highly irritating (IUCLID (2000)). Based on these results, the substance was classified into Category 2.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Not classified - - - - Since the substance was a non-sensitizer in guinea pig maximizing tests (ECETOC TR. 64 1995), it was classified into "Not classified".
5 Germ cell mutagenicity Not classified - - - - Based on negative results from in vivo mutagenicity tests using somatic cells (micronucleus tests using the mouse bone marrow cells) (DFGOT vol. 7 1992), the substance was classified into "Not classified". In in vitro mutagenicity tests, strong positive results did not occur based on several indices.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Not classified - - - - No effects of exposure were observed, other than slightly reduced body weight of the offspring in one-generation reproductive tests using rats that underwent oral administration (OECD TG 415), one-generation reproductive tests via dermal administration, and 13-week reproductive tests (DFGOT vol. 7 (1992), EU-RAR (1997), HSDB (2007)). In addition, animal exposure tests were conducted using rats that underwent oral and hypodermic administration, using mice that underwent oral administration, and using rabbits that underwent dermal administration during the gestational periods including the organogenetic periods. In these tests, no adverse effects on development of the offspring and teratogenicity were observed with an exception of decreased litter size detected in 1 of 2 mouse tests (DFGOT vol. 7 (1992), EU-RAR (1997), HSDB (2007)). Since no adverse effects on reproductive functions and fertility of parents and development of the offspring were observed, the substance was classified into "Not classified". Regarding decreased litter size observed in treated mice during the organogenetic period (HSDB (2007)), it was assumed that this observation was made after parturition; however, no details including testing methods were provided.
8 Specific target organ toxicity - Single exposure Category 2 (central nervous system) Warning H371: May cause damage to organs (central nervous system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
In oral administration tests using rabbits, mortality occurred at 2000mg/kg (2130 uL/kg); at 1000-2000mg/kg, a prone position, transient atonia with prostration and rapid breathing, narcotic symptoms, and damage to kidneys were observed (DFGOT vol. 7 (1992)). In addition, damage to the central nervous system and kidneys is documented as acute symptoms of this substance (DFGOT vol. 7 (1992)). Although kidney damage in humans who were exposed to paint containing this substance has been documented (DFGOT vol. 7 (1992), BUA report 204 (1997)), the damage was thought to be caused by the synergistic action of alcohol and not by direct effects of the substance itself (DFGOT vol. 7 (1992)). In rabbit studies, no details, such as types and extent of kidney damage, have been documented. Thus, in terms of the kidney, classification is not possible, and in terms of the central nervous system, it was classified into Category 2.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In the 6-week (males only) and 13-week repeated oral administration tests using rats, NOAEL were 891mg/kg/day (cutoff value: 217mg/kg/day) and 250mg/kg/day, respectively (DFGOT vol. 7 (1992), HSDB (2007)). In 13-week dermal exposure tests using rats, systemic effects were not detected at the maximum dose of 2000mg/kg/day (EU-RAR (2007)). All tested doses were above the upper limit of the Category 2 guidance values. Other several repeated exposure tests via oral and dermal routes resulted in no detection of serious toxicity at the doses within the range of guidance values. Although these results indicated that the substance was to be classified into "Not classified" (oral, dermal), in conclusion, it was classified into "Classification not possible", because its toxic effects through inhalation were unclear.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - Based on 96-hour LC50 = 1300mg/L for fish (Bluegill), 48-hour EC50 > 100mg/L for crustaceans (Daphnia magna), and 96-hour EC50 > 100mg/L for algae (Scenedesmus) (EU-RAR, 1999), the substance was classified into "Not classified".
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since it is water soluble (water solubility = 1000000mg/L (PHYSPROP database, 2008)) and its classification for acute toxicity is "Not classified", the substance was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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