GHS Classification Result

Chemical Name：pentane-2,4-dione; acetylacetone
CAS：123-54-6

Result：
ID: 20A2050
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Its flash point is >= 23degC and <= 60degC.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Its autoignition point is 350degC (Ullmanns (E) (6th, 2003)), which is higher than 70degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Among documented rat LD50 values (760, 1050, 890, 1410, and 970mg/kg bw for male; 570mg/kg bw for female; and 800, 1000, and 55mg/kg bw for unidentified sex) (SIDS (accessed June 2008), PATTY (5th, 2001)), 8 values are equivalent to Category 4 and 1 value is equivalent to Category 3. Based on this evaluation, the substance was classified into Category 4.
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Among rabbit LD50 values (1370 (male), 790 (female), and 4870mg/kg bw), the lowest value of the 3 was used as a basis to classify the substance into Category 3.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since its rat LC50 = 1224ppm/4h, the substance was classified into Category 3.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - In Draize tests in which the substance was applied to rabbit skin for 4 hours, slight erythema and mild to moderate edema were observed. The average scores of these symptoms were < 1.5 after 24, 48, and 72 hours of application, and the symptoms disappeared after 7 days except for slight desquamation (SIDS (2003)). Based on these results, the substance was classified into "Not classified".
3 Serious eye damage/eye irritation Not classified - - - - In Draize tests using rabbits, no corneal clouding, slight conjunctival redness, mild to moderate chemosis of conjunctiva and secretion, and mild iritis were observed, and they disappeared in 24 hours (SIDS (accessed June 2008)). Based on these results, the substance was classified into "Not classified".
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - Because both human patch tests and skin sensitization tests using guinea pigs yielded ambiguous results, classification is not possible.
5 Germ cell mutagenicity Not classified - - - - Negative results were obtained from in vivo mutagenicity tests using somatic cells (micronucleus tests using the bone marrow cells of mice that underwent inhalation exposure, micronucleus tests using the bone marrow cells of rats that underwent intraperitoneal administration or inhalation exposure, and chromosomal aberration tests using the bone marrow cells of mice and rats) and in vivo mutagenicity tests using germ cells (chromosomal aberration tests using mouse spermatogonia) (SIDS (accessed inaccessed June 2008)). Thus, the substance was classified into "Not classified". In dominant lethal tests using mice, though slight effects of the substance were observed, it was thought to be attributed to unusually low control values. Among in vitro mutagenicity tests, Ames tests yielded weak positive results with Salmonella TA104, mutation tests using CHO cells yielded negative results, and chromosomal aberration tests yielded positive results under the presence of S9 (SIDS (accessed in June 2008)). Although positive results have been obtained from micronucleus tests using peripheral blood of mice that underwent intraperitoneal administration, the results were judged to be invalid by the expert.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - In inhalation exposure tests using pregnant rats during the organogenetic period, decreased body weight gain in maternal animals, decreased fetal weight, and delayed ossification were observed at a high administration dose (400ppm). However, no effects were observed in indicators of conception and development, and frequencies of malformation in external surfaces, organs, and skeletons were not different between treated and control animals (SIDS (accessed June 2008)). However, due to insufficient data regarding the effects of the substance on reproductive functions and fertility of parental animals that were exposed prior to mating, classification is not possible.
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects, Respiratory tract irritation） Warning H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation)
H335: May cause respiratory irritation (narcotic effects, respiratory tract irritation) 		P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		After rats were orally exposed to the substance at doses >= 485mg/kg and near the LD50, trembling, unsteady gait, coma, and narcosis were observed. After rats were exposed through inhalation at concentrations >= 2.619mg/L and near LC50, tremors, ataxia, decreased motor activity, a negative tail and toe pinch reflex, and a slow righting reflex were observed (SIDS (accessed in June 2008)). Furthermore, after rabbits were dermally exposed at 790-1370mg/kg, narcosis and coma were observed (SIDS (accessed in June 2008)). In humans that underwent inhalation exposure, dizziness and loss of consciousness were observed (SIDS (accessed in June 2008)). Based on these observations in both animals and humans, the substance was classified into Category 3 (narcotic effects). Moreover, in rats that underwent inhalation exposure, forced respiration, lacrimation, and encrustation around the eyes and nose were observed (SIDS (accessed in June 2008)), and in humans, the substance is documented to be irritating to the respiratory tracts (HSDB (2007)). Thus, the substance was classified into Category 3 (respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Category 2 (central nervous system, thymus) Warning H373: May cause damage to organs through prolonged or repeated exposure (central nervous system, thymus) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In repeated oral route exposure tests using rats that were treated 10-11 times during a 2 week period, mortality, laboured breathing, trembling, motor ataxia, necrosis of the thymus, and inflammation of mesenteric lymph nodes were observed at 500mg/kg/day or higher doses. Inhalation and skin exposure tests using rats also resulted in development of similar symptoms at high administration doses. Furthermore, because histopathological changes, such as neurodegradation of the brain and lymphocytic degradation of the thymus, were detected, general symptoms caused by the 2-week oral route exposure were thought to be the effects of the substance on the central nervous system. Since oral route exposure was conducted at 500mg/kg/day (90-day conversion: 76.9mg/kg/day) which is equivalent to the Category 2 guidance values, and since lymphocytic degradation of the thymus was observed, the substance was classified into Category 2 (central nervous system and thymus).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Since its 48-hour EC50 = 34.4mg/L for crustaceans (Daphnia magna) (SIDS, 2001), the substance was classified into Category 3.
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since its classification for acute toxicity is Category 3, it is rapidly degradable (readily biodegradable, BOD degradability: 83% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1991)), and its potential for bioaccumulation is estimated to be low (log Kow = 0.4 (SRC, 2005)), the substance was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information