GHS Classification Result

Chemical Name：diallyl phthalate
CAS：131-17-9

Result：
ID: 20A2051
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Since its flash point is 166degC (ICSC (2006), (NFPA (13th, 2006)), which is higher than the GHS-defined threshold of 93degC, the substance was classified into "Not classified".
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Since its autoignition point is 358degC (ICSC (2006)), which is higher than the GHS-defined threshold of 70degC, the substance was classified into "Not classified".
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Its melting point is -70degC (Chapman (ver.16.1, 2008), HSDB (2002), ICSC (2006)). Test methods applicable to liquid (melting point <= 140degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the rat LD50 values of 656 (female), 891 (male), 896 (SIDS, 2004), and 970mg/kg bw (DFGOT vol.9, 2007), the substance was classified into Category 4.
1 Acute toxicity （Dermal） Not classified - - - - Based on the rabbit LD50 values of 3.4ml/kg, 3300, 3360, 3800 (SIDS, 2004), and 3800-3900mg/kg bw (DFGOT vol.9, 2007), the substance was classified into "Not classified" using JIS classification criteria (Category 5 in the United Nations classification).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Its saturated vapour pressure concentration is 0.002mg/L (ICSC (2006)). Since the rat LC50 of 8.3mg/L (1h) (4-hour conversion: 2.1mg/L/4h) (SIDS, accessed in July 2008) is higher than its saturated vapour pressure concentration, its classification was done using concentration criteria for dusts and mists. Based on this information, the substance was classified into Category 4.
2 Skin corrosion/irritation Not classified - - - - In 24-hour exposure tests using rabbits (New Zealand White) (GLP-compliant), its primary irritation index was 0.5 (SIDS, accessed in July 2008). In 4-hour exposure tests using rabbits (DOT methods), the Primary Dermal Irritation Index was 0 (SIDS, accessed in July 2008). In another rabbit test with its method unspecified, the substance was found to be non irritating to the skin (PATTY (5th, 2001). Based on these results, the substance was classified into "Not classified".
3 Serious eye damage/eye irritation Not classified - - - - Since the substance was found to be not irritating in 3 rabbit tests (SIDS (2004)), the substance was classified into "Not classified".
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		In skin sensitization tests using mice (CBA/CaBkl) (local lymph node proliferation tests using mice), stimulation index values were 3.23 at the 5% dose and 10.74 at the 50% dose, and the substance was evaluated to be "sensitizing." (SIDS, accessed July 2008). Based on these results, the substance was classified into Category 1.
5 Germ cell mutagenicity Category 1B Danger H340: May cause genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on positive results obtained from in vivo mutagenicity tests (micronucleus tests using the mouse bone marrow cells) (SIDS, accessed July 2008), the substance was classified into Category 1B.
6 Carcinogenicity Classification not possible - - - - In 103-week oral administration (0-300mg/kg) tests using mice (B6C3F1), squamous cell papilloma was detected in the forestomach and it was thought to be attributed to the substance. However, the tests were not conducted with the maximum tolerance dose, and did not provided sufficient data (NTP TR 242, 1983). In 103-week oral administration (0-100mg/kg) tests using rats, mononuclear cell leukemia and bile duct hyperplasia were observed in females administered at 100mg/kg. However, highly variable data made the results ambiguous (NTP TR 284, 1985). As such, information on its carcinogenic effects is insufficient, and thus the substance was classified into "Classification not possible".
7 Reproductive toxicity Classification not possible - - - - In one-generation reproduction tests using rats (SD), maternal animals, treated with a toxic dose of 150mg/kg/day, failed to complete parturition, and dystocia was frequently observed as a secondary consequence of its general toxicity. No abnormality was observed in terms of numbers of corpora lutea, implantation site, rates of losing pre- and post-implantation embryos, and survival rates of the offspring. Although atrophy of epididymis was observed in male rats, there was no significant difference in epididymides weights relative to bodyweight. (SIDS, accessed in July 2008). Overall, since other information on reproductive toxicity in males was lacking, the substance was classified into "Classification not possible".
8 Specific target organ toxicity - Single exposure Category 2 (liver) Warning H371: May cause damage to organs (liver) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In inhalation (aerosol) tests using rats, the animals developed irritation in the eyes and respiratory passages and central nervous system, but these were symptoms detected in dead animals (DFGOT (vol.9, 2007)). In oral administration tests using rats and dermal administration tests using dogs, oedematous haemorrhage in the lung, intestine and liver and pulmonary congestion were the most common symptoms observed. However, no information on administration doses was provided. In addition, periportal liver cell necrosis in dogs (administration doses unspecified), and increased levels of the enzymes aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase were found (DFGOT (vol.9, 2007)). High levels of ALT were also observed in rats (Fischer 344) that received doses of 400mg/kg bw, and in mice (B6C3F1) that received instillation (i.v.) of 900mg/kg bw (DFGOT (vol.9, 2007)). Thus, based on high levels of enzymes detected in treated dogs and rats (Fischer 344), and since this substance is documented to be hepatotoxic (PATTY (5th, 2001)), the substance was classified into Category 2 (liver).
9 Specific target organ toxicity - Repeated exposure Category 2 (liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In 13-week oral administration tests using rats (Fischer 344) (GLP-compliant), symptoms such as cell degeneration around the portal veins at 50, 100, and 200mg/kg (males: 3/10, 2/10 and 9/10; and females: 0/0, 8/10, 10/10), necrosis at 200mg/kg (males: 5/10; and females: 7/10), fibrosis at 200mg/kg (males: 5/10; and females: 4/10), cirrhosis at 400mg/kg (males: 10/10), and bile duct hyperplasia at 200mg/kg (males: 8/10) were observed. Similarly, in 40-54-day oral administration tests using rats (Crj:Cd) (0-150mg/kg, OECD guidelines 421, GLP-compliant), symptoms such as fibrosis around the portal veins at 150mg/kg (90-day conversion: 67-90mg/kg) (males: 6/10; females: 9/10), necrosis (males: 5/10; females: 7/10), and bile duct hyperplasia (males: 6/10; females: 9/10) were observed. In oral administration (0-400mg/kg) tests using mice (B6C3F1), notable pathological changes were not observed. Based on these rat results (SIDS, accessed in July 2008; NTP TR 284, 1985; NTP TR 242, 1983), the substance was classified into Category 2 (liver).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since its 96-hour LC50 = 0.44mg/L for fish (medaka) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 1999), the substance was classified into Category 1.
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Its classification for acute toxicity is Category 1, it is rapidly degradable (BOD degradability in 28 days = 82.3% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1996)), and its potential for bioconcentration is estimated to be low (LogPow = 3.23 (PHYSPROP database, 2008)). Based on the information, the substance was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information