GHS Classification Result

Chemical Name:benzothiazole-2-thiol
CAS:149-30-4

Result:
ID: 20A2054
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Its flash point is 628degC (ICSC, (2004)), which is >= 70degC.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance does not contain oxygen, fluorine or chlorine.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on the rat LD50 of >= 3800mg/kg (PATTY, (5th, 2001)), the substance was classified into "Not classified" (Category 5 or "Not classified" in the United Nations classification).
1 Acute toxicity (Dermal) Not classified - - - - Based on the rabbit LD50 >= 7940mg/kg (PATTY, (5th, 2001)), the substance was classified into "Not classified".
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Its rat LC50 (4-hour conversion values) documented are > =722mg/m3 and >= 1270mg/m3 (BUA report 74, 1991). However, because only its lower limit values were indicated, classification is not possible.
2 Skin corrosion/irritation Not classified - - - - Since rabbit tests (PATTY (5th 2001)) resulted in that the substance was not an irritant, it was classified into "Not classified".
3 Serious eye damage/eye irritation Not classified - - - - Since rabbit tests found that the substance was not irritating to the eyes (PATTY (5th 2001), it was classified into "Not classified".
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
Since both modified Buehler tests (PATTY (5th 2001)) and maximization tests using guinea pigs (ECETOC 77 (1999)) found the substance sensitizing, it was classified into Category 1. In humans, this substance, which is used as a rubber accelerator, is indicated as an important cause of footwear contact dermatitis (ECETOC 77 (1999)). It is rated as R43 in the EU classification (equivalent to Category 1) (EU-Annex 1, accessed in July 2008).
5 Germ cell mutagenicity Not classified - - - - Negative results were documented from dominant lethal tests using mice (in vivo heritable mutagenicity tests using germ cells) (IUCLID (2000)), micronucleus tests using bone marrow and peripheral blood of rats and mice (in vivo mutagenicity tests using somatic cells) (IUCLID (2000)), and other micronucleus tests using mice (IUCLID (2000), HSDB (2003)). Therefore, the substance was classified into "Not classified".
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
In oral route tests using rats, increased occurrences of mononuclear cell leukemia, acinar cell tumors of the pancreas, adrenal gland pheochromocytoma (malignant and benign), and preputial gland adenoma were observed in males; and increased occurrences of adrenal pheochromocytoma and pituitary adenoma were observed in females. In oral route tests using mice, incidences of tumors did not increase in treated males, but incidences of hepatocyte adenoma and hepatoma increased in treated females at low doses (NTP TR 332, 1988). From these results, the substance was classified into Category 2.
7 Reproductive toxicity Not classified - - - - A reproduction study was conducted using two generations of rats that were fed with a diet containing the test substance (doses: 2500, 8750, and 15000 ppm) during the pre-mating through gestation period and during lactation. In this study, no effect of the treatment on reproductive indices was noted at any doses except for decreased body weights seen in F1 fetuses at 8750 ppm or higher doses. In a teratogenicity study using pregnant rats that received oral administration of the substance during the organogenetic period (doses: 300, 1200, and 1800 mg/kg), no adverse effects on fetal development, including any teratogenic effects, were reported although toxic symptoms were detected in maternal animals that received 1200 mg/kg or higher doses. In another teratogenicity study using pregnant rabbits that underwent oral administration (doses: 50, 150, and 300 mg/kg) during the organogenetic period, no signs of embryo- or developmental toxicity were noted at any doses (PATTY (5th, 2001). Thus, regarding this test substance, no adverse effects on sexual functions or fertility were found in a two-generation reproduction study using rats, and no adverse effects on fetal development were noticed in rats or rabbits in developmental studies. Based on these negative results, the substance was classified into the "Not classified" category.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In 13-week oral route tests using rats, no adverse effects, other than hepatomegaly, were observed in males treated at the doses of 188, 375, 750, and 1500mg/kg (NTP TR 332, 1983). In 13-week oral route tests using mice, coma occurred at 375mg/kg, symptoms of clonic seizures were observed at 750 and 1500mg/kg, and half of the treated animals died at 1500mg/kg. Although it was indicated that the substance affects the central nervous system at doses higher than Category 2 guidance values, no detailed information is provided (NTP TR 332, 1983). In other tests using rats that were fed a diet containing the substance for 4 weeks, no effects were observed at doses up to 25000ppm (500mg/kg bw) (IUCLID (2000)). Overall, since no other detailed data were available, the substance was classified into "Classification not possible".
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since its 72-hour EC50 = 0.5mg/L for algae (Pseudokirchneriella subcapitata) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 1999), the substance was classified into Category 1.
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since its classification for acute toxicity is Category 1 and it is not rapidly degradable (non-biodegradable, BOD degradability: 2.5% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1977)), the substance was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


To GHS Information