GHS Classification Result

Chemical Name：3-aminopropyltriethoxysilane
CAS：919-30-2

Result：
ID: 20A2060
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Its flash point is 96degC (closed cup) (SIDS (accessed July 2008)), which is >= 93degC.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Classification not possible - - - - No data available.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Its melting point is -70degC (SIDS, accessed in July 2008). Test methods applicable to liquid (melting point <= 140degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - It contains metalloid silane and its water solubility is 7.6*10^5mg/L at 25degC (SIDS (accessed in July 2008)). Based on the information, the substance was classified into "Not classified".
13 Oxidizing liquids Classification not possible - - - - The substance contains oxygen (but not fluorine or chlorine), with oxygen chemically bonded to Si. Although the substance is classifiable, classification is not possible due to insufficient data available.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - Its boiling point is 217degC (Sax (11th, 2004), HSDB (2002)), which is >= 55degC. Classification is not possible due to insufficient data.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		The tests using rats resulted in the LD50 values of 1570mg/kg (females), 2830mg/kg (males), and 3.65ml/kg (both sexes) (SIDS, (accessed in July 2008)). Of these LD50 values documented, 1570mg/kg (females) was adopted for the basis to classify the substance into Category 4, because the value was obtained from a GLP test and was a conservative estimate. In addition, the substance is listed as R22: harmful if swallowed, in the EU Risk Phrases (EU-Annex 1, accessed in July 2008).
1 Acute toxicity （Dermal） Not classified - - - - Based on the rabbit LD50 value of 4.29g/kg bw (SIDS, (accessed July 2008)), the substance was classified into "Not classified" using JIS classification criteria (Category 5 in the United Nations classification).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Its rat LC50 is documented to be >= 16ppm (4-hour conversion: >= 19.6ppm) in an inhalation test using rats (SIDS, accessed July 2008). Since the data was insufficient, the substance was classified into "Classification not possible".
1 Acute toxicity （Inhalation: Dusts and mists） Not classified - - - - Based on its LC50 of 7.35mg/L (unit conversion: 812ppm) obtained from a 4-hour inhalation test using rats (SIDS, accessed July 2008), the substance was classified into "Not classified".
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In the rabbits tests, alopecia, ulceration, and necrosis were observed. In addition, ecchymosis and moderate to severe edemas, though these symptoms were reversible, were observed (SIDS, accessed in July 2008). Since these observations indicate serious skin corrosion, the substance was classified into Category 1. Since no Draize score is available, refined classification within Category 1 is not available.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		The data was obtained from tests using rabbits (OECD405). Corneal necrosis was observed in both rabbits with eyes unwashed and rabbits with eyes washed after the application (SIDS, accessed July 2008). Based on these results, the substance was classified into Category 1.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		In the guinea pig tests, in which peanut oil was used as a medium (1997), the substance was found to be irritating, and thus it was classified into Category 1. In 2 other tests (1996, 1987), physiological saline and water were used as media, which hydrolyzed the substance (SIDS, accessed July 2008). Thereby, the data was not evaluated for the classification of the substance.
5 Germ cell mutagenicity Not classified - - - - Based on the negative results obtained from micronucleus tests using the bone marrow cells of mice that underwent intraperitoneal administration (in vivo mutagenicity tests using somatic cells) (SIDS, accessed July 2008), the substance was classified into "Not classified". Also, in vitro mutagenicity tests (Ames tests and chromosomal aberration tests using CHL cells) yielded negative results (SIDS (accessed July 2008)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - In developmental toxicity tests using rats that underwent oral administration during the organogenetic period (SIDS, accessed in July 2008), non-ossification of presacral vertebrae and sternebra unossified was detected in the offspring at doses that suppressed body weight gain of parental animals. However, these results were not interpreted as clear cases of developmental toxicity. Since the information on sexual functions and fertility of parental animals was insufficient, the substance was classified into the "Classification not possible" category.
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation, Narcotic effects） Warning H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects)
H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects) 		P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In oral administration tests using rats (OECD TG 401), symptoms such as motor ataxia and lethargy were observed at lethal dose (5.0mL/kg). In addition, in inhalation tests using rats (OECD TG 403), slow righting reflex, labored breathing, hypoactivity, ataxia and discharge from the mouth, nose and eyes were observed at the administration dose of 7.35mg/L, and these symptoms disappeared in 3 days (SIDS, accessed in July 2008). Based on these results, the substance was classified into Category 3 (respiratory tract irritation and narcotic effects).
9 Specific target organ toxicity - Repeated exposure Category 2 (respiratory system) Warning H373: May cause damage to organs through prolonged or repeated exposure (respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In the aerosol inhalation tests using rats, symptoms such as irritation to the respiratory system, inflammation, and metaplasia occurred at the concentration of 150mg/m3/6h (4-week exposure) (SIDS, accessed July 2008). Based on these results, the substance was classified into Category 2 (respiratory system).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - Based on its 96-hour LC50 of >= 934mg/L for fish (zebra fish), 48-hour EC50 of 331mg/L for crustaceans (Daphnia magna), and 72-hour EbC50 of 603mg/L for algae (Scenedesmus) (SIDS, 2005), the substance was classified into "Not classified".
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since it is water soluble (water solubility = 760000mg/L (SIDS, 2005)) and its classification for acute toxicity is "Not classified", the substance was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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