GHS Classification Result

Chemical Name:3-butoxypropan-2-ol; propylene glycol monobutyl ether
CAS:5131-66-8

Result:
ID: 20A2066
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Since its flash point is 63degC (ICSC (2005), ICSC (J) (2005)), the substance was classified into Category 4.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Its autoignition point is 260degC (ICSC (2005), ICSC (J) (2005)), which is >= 70degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Excluding results from secondary documents, the rat LD50 values obtained were 3300mg/kg (OECD TG 401), 1900mg/kg, and 2500mg/kg (SIDS, accessed July 2008). Two of the three LD50 values fell into the "Not classified" category, and one of them resulted from a test that was compliant with OECD TG 401 and thus is a most reliable value. Based on this LD50 value, the substance was classified into "Not classified" (this classification was based on JIS criteria, while the substance is in Category 5 based on the United Nations GHS classification).
1 Acute toxicity (Dermal) Not classified - - - - The following LD50 values have been documented for this substance: > 2000mg/kg (OECD TG 401) and 2640mg/kg for rats, > 2000mg/kg, 3133mg/kg, 3100mg/kg, and 1400mg/kg for rabbits (SIDS, accessed in July 2008). The substance was classified into "Not classified" because all of the LD50 values listed above, except for one rabbit valuefor, fell within the range of "Not classified" guidance values.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - It has been documented that its rat LC50 values were > 3.52mg/L/4h and > 5.83mg/L/8h (equivalent to > 7.04mg/L/4h) (its saturated vapour pressure is 9.97mg/L). However, mortality was not observed among the treated animals in these tests (SIDS, accessed in July 2008). Consequently, the substance was classified into "Classification not possible".
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
Its classification was based on skin irritation tests using rabbits (OECD TG 404) in which applications of undiluted and 75% solutions for 4 hour resulted in the primary skin irritation index values of 4.0 and 2.5, leading to the conclusion that the substance was moderately irritating (SIDS (2000)).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
The tests in which the undiluted substance was applied into the eyes of rabbits (OECD guidelines 405) resulted in observations of mild corneal clouding (score: 0), edemas of iris veins (score: 0.2), occasional marked chemosis of the conjunctiva (score: 2.2), and redness (score: 1.0), which led to conclude that the substance was moderately irritating (SIDS (accessed July 2008)). However, since these symptoms disappeared within 7 days (SIDS (accessed July 2008), it was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Not classified - - - - In a skin sensitization test using guinea pigs (Buehler test: OCD guidelines 406), the substance was not sensitizing to skin by challenge (SIDS, accessed July 2008). Based on this result, the substance was classified into "Not classified".
5 Germ cell mutagenicity Classification not possible - - - - Negative results have been obtained from in vitro mutagenicity tests (Ames tests, chromosomal aberration tests, and mouse lymphoma tests) (SIDS, accessed July 2008). However, since there was no data from in vivo tests, classification is not possible.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No toxicity of this substance was observed in terms of general toxicity in maternal animals, fetotoxicity, and teratogenic effects, in tests using rats and rabbits that underwent dermal administration during the organogenetic period (SIDS (accessed in July 2008)) and tests using mice that were treated by either ingestion or subcutaneous injections (PATTY (5th, 2001)). However, no data is available on effects of the substance on the reproductive functions and fertility of parental animals due to pre-mating exposure. Therefore, classification is not possible because of insuficient data.
8 Specific target organ toxicity - Single exposure Category 3 (Narcotic effects) Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
Rats that were orally administered with 1800-3200mg/kg of the substance showed symptoms such as lethargy and coma, but these symptoms disappeared within 2 days in surviving animals (SIDS (accessed July 2008)). Based on these results, the substance was classified into Category 3 (narcotic effects).
9 Specific target organ toxicity - Repeated exposure Not classified (oral, dermal, inhalation) - - - - In 31-day inhalation exposure tests using rats, 13-week oral exposure tests using rats, 13-week dermal exposure tests using rats, and 13-week dermal exposure tests using rabbits, NOAEL values of the substance were 3.244mg/L (90-day correction: 1.117mg/L), 350mg/kg/day, 880mg/kg/day, and 1000mg/kg/day, respectively (SIDS (accessed in July 2008)). Because all of these NOAEL values exceeded the upper limit of the Category 2 guidance values, the substance was classified into "Not classified" (oral, dermal, inhalation). As relevant information, in these tests documented above, noticeable effects related to the exposure of this substance were rarely observed, with only the exception that increased liver and kidney weights, both without associated histopathology, and slight alterations in some of the clinical test values, were observed at the high dose level (1000mg/kg/day) in 13-week oral exposure tests using rats (SIDS (accessed in July 2008)).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - Based on its 96-hour LC50 values of 560-1000mg/L for fish (guppies), 48-hour EC50 of > 1000mg/L for crustaceans (Daphnia magna), and 96-hour EC50 of > 1000mg/L for algae (Pseudokirchneriella subcapitata) (SIDS, 2005), the substance was classified into "Not classified".
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since it is water soluble (water solubility = 4.21E+004mg/L (PHYSPROP database, 2008)) and its classification for acute toxicity is "Not classified", the substance was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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