Chemical Name：bioresmethrin; (5-bezylfur-3-yl)methyl(1R)-trans-2,2-dimethyl-3-(2-methylpropenyl)cyclopropanecarboylate
CAS：28434-01-7

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 4		Warning	H302: Harmful if swallowed	P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ...	Documented rat LD50 values consist of the same number of data of 675 mg/kg (EHC 92 (1989); original literature, 1986), 840 mg/kg (original literature, 1984), 990 mg/kg (original literature, 1979), 7071 mg/kg (original literature, 1970), > 8000 mg/kg (original literature, 1972), and 8800 mg/kg (original literature, 1969), which are equivalent to the guidance values of "Not classified" (>= 2000 mg/kg bw), and 675 - 990 mg/kg bw (EHC 92, 1989; EHC (J) 92, 1990) which are equivalent to the guidance values of Category 4 (300 - 2000 mg/kg bw). Thus, data with later original literatures were adopted and the substance was classified into Category 4.
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	A dermal test using rats showed LD50 >= 10000 mg/kg bw (EHC 92, 1989; JMPR 356, 1976), which is equivalent to the guidance values (JIS, >= 2000 mg/kg bw; GHS, >= 5000 mg/kg bw) of "Not classified".
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition) Since its melting point is 30 - 35degC and the substance is a viscous oil or paste (ICSC (J), 2001), its physicochemical hazard as a liquid was also considered.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	A inhalation test on rats (EHC 92, 1989; JMPR 356, 1976), with unknown exposure route, is considered to be conducted with the substance in the form of a mist or powder, because the vapour pressure is reported to be 0.00014 mmHg (25degC) (reference document, SRC (accessed June 2008)). However, since the LC50 >= 0.872 mg/L (for 24 hours), which is >= 0.145 mg/L (for four hours), and is equivalent to the guidance values of Category 2 - Not classified, classification is not possible.
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	No data available.
3	Serious eye damage/eye irritation	Not classified	-	-	-	-	Since it is documented in a rabbit test that instillation of the substance did not produce any irritation or corneal damage, or any indication of ocular hazard (EHC 92, 1989; JMPR 356, 1976), it was classified into "Not classified".
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	Since it is documented in a guinea pig test that the substance showed only traces of erythema suggesting a low potential for sensitization and irritation (EHC 92, 1989; JMPR 356, 1976), and the test did not conclude its skin sensitization, the substance was classified into "Classification not possible".
5	Germ cell mutagenicity	Category 2		Warning	H341: Suspected of causing genetic defects	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Since the substance was positive in a mutagenicity test (rat micronucleus test) (ATSDR, 2003), it was classified into Category 2.
6	Carcinogenicity	Classification not possible	-	-	-	-	No data available.
7	Reproductive toxicity	Category 1B		Danger	H360: May damage fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Since it was documented that in a rabbit test, there was no apparent effect on parents in the study, a large amount of resorption was noted at all treatment levels (EHC 92, 1989; JMPR 356, 1976), the substance was classified into Category 1B.
8	Specific target organ toxicity - Single exposure	Category 3 （Narcotic effects）		Warning	H336: May cause drowsiness or dizziness (narcotic effects)	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ...	Two hours after oral administration, the animal went into spasms, became nervous toward other animals and aggressive. Finally, the animal experienced spasms, weakening, coma, and died within 24 hours. Since the substance showed neurotoxicity at doses above the guidance value, it was classified into Category 3 (narcotic effects).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	It was documented that in a oral administration test using rats for 91 days, fatty infiltration of the liver was noticed at 1200 mg/kg diet or higher, when converted, the dose is 60 mg/kg/day bw (EHC 92, 1989; EHC (J) 92, 1990; JMPR 356, 1976). In addition, in an oral administration test using dogs for 90 days, the NOAEL was 80 mg/kg, and no adverse effects were observed on histopathological examination, although effects on blood system were seen at 250 mg/kg (EHC 92, 1989). Thus, the substance was classified into "Classification not possible".
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since its 96h-LC50 = 0.0008 mg/L for fish (bluegills) (ECOTOX, 2008), the substance was classified into Category 1.
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since its preexisting classification for acute toxicity is Category 1 and it is not rapidly degradable (SRC: BioWin V4.10), the substance was classified into Category 1.