Chemical Name:iodoacetic acid
CAS:64-69-7
ID: | 20A2073 |
Classifier: | Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE) |
Year Classified: | FY2008 |
Reference Manual: | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Solid (room temperature) |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (room temperature) |
5 | Gases under pressure | Not applicable | - | - | - | - | Solid (room temperature) |
6 | Flammable liquids | Not applicable | - | - | - | - | Solid (room temperature) |
7 | Flammable solid | Classification not possible | - | - | - | - | No data available. |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (room temperature) |
10 | Pyrophoric solids | Classification not possible | - | - | - | - | No data available. |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | No data available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (room temperature) |
14 | Oxidizing solids | Not applicable | - | - | - | - | The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure |
16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 | Danger | H301: Toxic if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
Since its LD50 = 83 mg/kg for mice (HSBD (2003)) and the substance is rate R25 in EU classification (EU Annex I (accessed July 2008)), it was classified into Category 3. | |
1 | Acute toxicity (Dermal) | Category 2 | Danger | H310: Fatal in contact with skin |
P302+P350: IF ON SKIN: Gently wash with plenty of soap and water. P262: Do not get in eyes, on skin, or on clothing. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P322: Specific treatment (see ... on this label). P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
Since its LD50 = 125 mg/kg for guinea pigs (RTECS (2008): National Technical Information Service. (Springfield, VA 22161), Formerly U.S. Clearinghouse for Scientific & Technical Information, OTS0571891), the substance was classified into Category 2. | |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Solid (room temperature) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | No data available. |
2 | Skin corrosion/irritation | Category 1 | Danger | H314: Causes severe skin burns and eye damage |
P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment (see ... on this label). P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
Two human cases of severe and bullous contact dermatitis have been reported (HSDB (2003)), and it is rated R35 in EU classification (EU Annex I (assessed on July, 2008)) and its pH = 1.4 (20degC, 50 g/L) (GESTIS (accessed July 2008)). Thus, the substance was classified into Category 1. | |
3 | Serious eye damage/eye irritation | Category 1 | Danger | H318: Causes serious eye damage |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. |
It has been documented to be a high irritant to human eyes and mucous membrane (HSDB (2003)), and rated R35 in EU classification (EU Annex I (accessed July 2008)) and its pH = 1.4 (20degC, 50 g/L) (GESTIS (accessed July 2008)). Thus, the substance was classified into Category 1. As relevant information, it is also classified as a corrosive agent to skin. | |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | The only available datum is a weakly positive result from an Ames test (NTP DB (accessed July 2008)), and no other data are known. |
6 | Carcinogenicity | Classification not possible | - | - | - | - | The only available report is that subcutaneous administration to rats for 596 days produced a case of fibroma, a case of fibrosarcoma, and a case of plasma cell sarcoma (HSDB (2003)). No other data are known, thus, the substance cannot be classified. |
7 | Reproductive toxicity | Classification not possible | - | - | - | - | Non-oral administration to mice has been reported to cause defective ribs and vertebras and cleft palate (Birth Defects (3rd, 2000)). However, this study was performed relatively many years ago (1959, 1973), and does not provide information on such factors as the administration route and doses. Thus the substance cannot be classified due to lack of data. |
8 | Specific target organ toxicity - Single exposure | Category 2 (eye) | Warning | H371: May cause damage to organs (eye) |
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ... |
Human exposure studies showed that the substance is toxic to essentially all parts of the eye, the cornea, iris, lens, ciliary body, and retina, when either applied directly or administered systemically (HSDB (2003)). In addition, its intravenous injection in rabbits, cats, and rats were found to induce cataracts, as well as to affect each part of the eye, such as lens, iris, and retina (HSDB (2003)). Since adverse effects on the human eyes after whole body exposure is indicated in the document of List 2, the substance was classified into Category 2 (eye). | |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (systemic toxicity) | Warning | H373: May cause damage to organs through prolonged or repeated exposure (systemic toxicity) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
The substance is documented to be highly capable of causing death or permanent injury due to exposures of normal use to humans (HSDB (2003)), and is reported that exposure orally to rats in their diet, 50 - 70 mg/kg/day has been found to be fatal in 10 - 40 days (HSDB (2003)). These human and rat data included in List 2 provide findings of death only, and do not provide findings on target organs. Thus, the substance was classified into Category 2 (systemic toxicity). | |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Classification not possible | - | - | - | - | No data available. |
11 | Hazardous to the aquatic environment (Long-term) | Classification not possible | - | - | - | - | No data available. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |