GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：2-chloropropane
CAS：75-29-6
Result：
| ID: | 20A2075 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2008 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （Sep, 2008） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 2 |
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Danger | H225: Highly flammable liquid and vapour |
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Its flash point is -32degC (Closed cup, Merck (14th, 2006)), which is under 23degC, and its initial boiling point is 35 - 36degC (Merck (14th, 2006)), 36.5degC (Ulmanns (E) (6th, 2003)), and 35.7degC (Howard (1997)), which are above 35degC. Thus, the substance was classified into Category 2. |
| 7 | Flammable solid | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Classification not possible | - | - | - | - | No data available. |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | The substance contains chlorine (but not oxygen or fluorine) which is chemically bonded only to carbon. |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Classification not possible | - | - | - | - | Classification not possible due to lack of data. As relevant information, its LD50 for rats is documented to be 5000 mg/kg (RTECS (2005)). |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | The substance was administered to rats at a saturated vapour concentration of 2183 mg/L (678000 ppm) for six minutes or 8000 ppm for four hours. At the saturated concentration, all animals died within six minutes. At 8000 ppm, all animals survived (HSDB, 2003). Since the saturated vapour concentration was described to be 678000 ppm, the test is considered to be conducted in vapour with almost no included mists, and the cut off value for the gas was used. No other data are available, thus, the substance cannot be classified. As relevant information, it is rated Xn; R20/221/22 in EU classification. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Not classified | - | - | - | - | Since it is documented that on the open surface of the skin of rabbits, the substance caused very little irritation, and when it was bandaged on the skin, some erythema and superficial irritation resulted (HSDB, 2003), it was classified into "Not classified" using JIS classification criteria (equivalent to Category 3 in UN classification). |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | It is documented that the substance was administered to rabbits, that slight pain and slight conjunctival irritation were present in unwashed eyes, while very slight pain and slight conjunctival irritation were present in washed eyes, and that all eyes began to heal within 48 hours (HSDB (2003)). Since levels of signs are not known, and due to lack of data, the substance was classified into "Classification not possible". |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Since no data of in vivo mutagenicity test and in vivo genotoxicity are available, also no results of in vitro mutagenicity test with multiple indexes are available, classification is not possible. As relevant information, positive and negative results of Ames tests (in vitro mutagenicity test) have been reported (Patty 5th (2001), HSDB (2003)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available. |
| 8 | Specific target organ toxicity - Single exposure | Category 3 （Narcotic effects） |
|
Warning | H336: May cause drowsiness or dizziness (narcotic effects) |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ... |
The substance was administered to rats at a saturated vapour concentration of 2183 mg/L (approximately 678000 ppm) for six minutes or 25.7 mg/L (8000 ppm) for four hours. At the saturated concentration, all animals were anesthetized in three minutes and died within six minutes, while at 8000 ppm, animals were very slightly depressed at end of exposure (HSDB (2003)). Based on these results, the substance was classified into Category 3 (narcotic effects). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | Rats, guinea pigs, rabbits, and monkeys exposed via inhalation for seven hr/day, five days/week over a period of 181 days survived a level of 1000 ppm (3.21 mg/L), being above the guidance values of Category 2. Microscopic findings concluded tissue changes in the liver (slight to marked necrosis of the parenchymal cells in the portal area) and the kidney (tubular degeneration of the epithelium with some necrosis) (HSDB (2003)). However, since the lower limit of the toxic dose is unknown, and due to lack of data, the substance was classified into "Classification not possible". |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |