GHS Classification Result

Chemical Name：1-aminopropan-2-ol; isopropanolamine
CAS：78-96-6

Result：
ID: 20A2076
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Its flash point is 77degC (closed system) (Hommel (1996)), which is above 60degC and below 93degC.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Its autoignition point is 374degC (NFPA (2006)), which is 70degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Since its LD50 = 4260 mg/kg, 4000 mg/kg, and 2098 mg/kg for rats (DFGOT (1998)), the substance was classified into "Not classified" using JIS classification criteria (equivalent to Category 5 of UN classification).
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Since its LD50 = 1560 mg/kg and 1851 mg/kg for rabbits (IUCLID (2000)), the substance was classified into Category 4.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Insufficient data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Exposure time of 15 minutes and longer to undiluted application to rabbit skin led to the development of necrosis (DFGOT (1998)), and in a DOT corrosivity test, the substance was classified as corrosive to the skin (DFGOT (1998)). Thus, it was classified into Category 1. As relevant information, the pH of its high-concentration solution (10 g/L) is 11.3 (20degC) (IUCLID (2000)), and the substance is rated R24 in EU classification.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Undiluted instillation of it into the rabbit eye caused severe conjunctival congestion, moderate reddening of the iris, and clouding of the cornea, and corneal defects were observed 21 days after the treatment (DFGOT (1998)). In another test, the substance caused corrosion or severe irritation, and corneal clouding and cataracts developed (DFGOT (1998)). Based on above results, it was classified into Category 1. As relevant information, the pH of its high-concentration solution (10 g/L) is 11.3 (20degC) (IUCLID (2000)), and the substance is rated R24 in EU classification.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Not classified - - - - Since it is documented that its solution was applied to the dorsal skin of 150 male and female persons nine times within three weeks, during the challenge treatment two weeks later, the substance did not induce allergic dermatitis (DFGOT (1998)), it was classified into "Not classified". As relevant information, in another test, the substance was applied to the skin of 25 male and 25 female persons on three consecutive days, and the application site was irradiated with UV light, the substance did not induce photoallergic reactions (DFGOT (1998)).
5 Germ cell mutagenicity Classification not possible - - - - Since in vivo data are not available, classification is not possible. As relevant information, as for in vitro data, mutagenicity tests using bacteria were conducted, and some of them reported positive results (NTP DB (accessed November 2008)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - The sole information on reproductivity is that of a study in which pregnant rats were exposed to the substance for the whole gestation period, and on day 21 of gestation the animals were killed and the foetuses examined. However, since it is described that this study is inadequately documented and its significance can therefore not be assessed (DFGOT (1998)), data are obviously lacking.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Insufficient data available. As relevant information, in a test in which animals were exposed to saturated vapour for 30 and 90 minutes, mucosal irritation was seen, but the vapour concentration could not be estimated more precisely because some of the vapour condensed on cooler parts of the cage.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In a test, rats were given the substance in their diet for 90 days, and the highest dose (2200 mg/kg/day bw) caused only changes in the weights of kidneys and the liver (DFGOT (1998)). Also, in a test in which mice and rats were inhalation exposed to the concentrations up to 0.24 mg/L (90-day inversion guidance value, 0.037 mg/L) for two weeks, the substance had no effect (DFGOT (1998)). The former test using rats did not describe any significant effect at doses above the upper limit of guidance values, but since the test was conducted many years ago (1951), it is doubtful to classify based on the information. Also, in the latter test, toxic effects were not observed, but since dose levels were too low, the data cannot contribute to the classification. Accordingly, the substance was classified into "Classification not possible".
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Since its 72h-EC50 = 23 mg/L for algae (Scenedesmus) (IUCLID, 2000), the substance was classified into Category 3.
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Since its preexisting classification for acute toxicity is Category 3 and reliable data on its rapid degradability are not available, the substance was classified into Category 3.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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