GHS Classification Result

Chemical Name:biphenyl-2-ylamine
CAS:90-41-5

Result:
ID: 20A2081
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Its autoignition point is 450degC (Chapman ver. 16:1 (2008)), which is above 70degC.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance does not contain oxygen, fluorine or chlorine.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on its LD50 = 2340 mg/kg for rats (NTP TR233 (1982)), the substance was classified into "Not classified" using JIS classification criteria (equivalent to Category 5 in UN classification). As relevant information, in a single administration test by using five dosing groups of rats (each group consisted of two males and two females) with doses of 1, 10, 100, 1000, and 10000 mg/kg, doses of 1000 mg/kg or less did not cause death (NTP TR233 (1982)).
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - A somatic cell in vivo genotoxicity test, SCE test, showed negative results (HDBD, 2004), while, in vitro mutagenicity tests, Ames test (NTP DB (accessed November 2008)) and chromosomal aberration test (RTECS (2006)), showed positive results. Since no in vivo mutagenicity test data are available, the substance cannot be classified due to lack of data. As relevant information, positive results from the in vitro chromosomal aberration test are considered to be caused from cytotoxicity (Environ. Mol. Mutagen., 43, 36-44, 2004).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
In a diet feeding test of 2-phenylaniline hydrochloride to rats and mice for 103 weeks, there was a slight decrease in body weight gain in rats of each sex at the end of the test, survival of dosed rats was comparable with that of the control, and there were no increased incidences of tumors in rats that could be associated with chemical administration (NTP TR233 (1982)). While, in mice, there were little or no differences in body weight changes between dosed and control groups, survival of high-dose males was significantly less than that of females, low-dose and control mice, a dose-related increase in incidences of hemangiosarcoma was observed in males and females (NTP TR233 (1982)). In addition to above results in mice, it is classified into Category 3; R40 in EU classification. Thus, the substance was classified into Category 2.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 3 (Narcotic effects) Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
After oral administration to rats and mice, in high-dose death cases, hyperexcitability followed by prostration and shallow breathin were observed, while in medium-, low-dose survival rats, lethargy was found within 24 hours after administration (NTP TR233 (1982)). Additionally, another test using rats reported coma as a sign after oral administration (RTECS (2006)). Thus, the substance was classified into Category 3 (narcotic effects).
9 Specific target organ toxicity - Repeated exposure Category 2 (hematopoietic system) Warning H373: May cause damage to organs through prolonged or repeated exposure (hematopoietic system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
After oral administration to rats for 14 days, at doses >= 10000 ppm (90-day conversion, 77.8 mg/kg/day), hypertrophy of the spleens was shown, at doses >= 3000 ppm (90-day conversion, 23.3 mg/kg/day), hypertrophy of mesenteric lymph nodes and bleeding in renal medulla were recognized. Also after oral administration of 1000 - 30000 ppm (90-day conversion, 23.3 - 700 mg/kg/day) to rats for 14 days, hypertrophy of lymph nodes and bleeding in renal medulla were observed in all treated animals. In an oral administration test to rats and mice for 13 weeks, dose-related decrease in hemoglobin, erythrocyte count, and hematocrit and increase in leukocyte count were observed, and histopathologically, hemosiderosis, congestion and extramedullary hematopoiesis were present in the spleens of males received >= 3000 ppm (150 mg/kg/day) and females received >= 1000 ppm (50 mg/kg/day). Effects on the kidney observed in the oral administration test for 14 days were not found in mice orally administered for 13 weeks, and in cases of rats, at the maximum dose of 30000 ppm (1500 mg/kg/day), being above the guidance value range, symptoms such as renal tubular degeneration, necrosis of papilla, and interstitial fibrosis were observed, but elongated exposure reduced the effects. Thus, findings of the kidney were not adopted as the base of classification. Taking these results into account, changes in blood indexes suggested anemia, histopathological changes in the spleens, and erythroblastic hyperplasia in bone marrow observed at doses >= 10000 ppm (500 mg/kg/day) for 13 weeks, and the substance was classified into Category 2 (hematopoietic system).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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