GHS Classification Result

Chemical Name:MCPB (ISO); 4-(4-chloro-o-tolyloxy) butyric acid
CAS:94-81-5

Result:
ID: 20A2083
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Classification not possible - - - - No data available. As relevant information, it has been documented to be non-flammable (HSDB (2007)).
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available. As relevant information, it has been documented to be non-flammable (HSDB (2007)).
11 Self-heating substances and mixtures Classification not possible - - - - No data available. As relevant information, it has been documented to be non-flammable (HSDB (2007)).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance contains chlorine and oxygen, which are chemically bonded only to carbon and hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Since its LD50 for rats has been reported to be 4300 mg/kg, 1570 mg/kg, and 680 mg/kg, and LD50 for mice to be 800 mg/kg (all of them, HSDB (2007)), and based on lower doses (680 mg/kg, 800 mg/kg, and 1570 mg/kg), the substance was classified into Category 4.
1 Acute toxicity (Dermal) Not classified - - - - Since its LD50 > 10000 mg/kg for rabbits (HSDB (2007)), the substance was classified into "Not classified".
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - It has been reported to be non-corrosive (HSBD (2007)). However, since no specific test results are available, classification is not possible.
3 Serious eye damage/eye irritation Classification not possible - - - - It has been reported to cause pain and irritation on eyes (HSBD (2007)). However, since no data are available, classification is not possible.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - No data available.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - It is reported that dogs were fed diets containing the substance where general toxic effects such as increase in the gallbladder/liver function test dye, sulfobromophthalein (BSP), retention, inhibited body weight gain, and tubular atrophy were observed. Effects including small testicles, curtailment of spermatogenic activity, and immature prostate were observed (IRIS (2002)). Also, in a diet feeding test using rats, even at high doses where general toxic effects such as discolored liver lobes, elevated absolute and relative liver and kidney weights were observed, no treatment-related effects on behavior, appearance, growth rate, food consumption, hematology, or urinalysis were found (IRIS (2002)). However, since these reports do not provide any distinct information showing productive toxicity in parental animals and developmental toxicity in offspring, and due to lack of data, the substance cannot be classified.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In a diet feeding test for 13 weeks using dogs (males), the following effects were observed at the dose of 40 mg/kg/day: increase in the gallbladder/liver function test dye, sulfobromophthalein (BSP), retention, decrease in organ weight ratios, tubular atrophy, and immature or atrophic prostate (IRIS (2002)). In a diet feeding test for 90 days using rats, the following effects were observed at the dose of 40 mg/kg/day: discolored liver lobes, elevated absolute and relative liver and kidney weights, and the like (IRIS (2002)). However, since these reports do not provide any histopathological information, the substance cannot be classified.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Since its 96h-LC50 = 3.3 mg/L for fish (bluegills) (HSDB, 2007), the substance was classified into Category 2.
11 Hazardous to the aquatic environment (Long-term) Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since its preexisting classification for acute toxicity is Category 2 and it is estimated not to be rapidly degradable (SRC: BioWin V4.10), the substance was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


To GHS Information