GHS Classification Result

Chemical Name：monobenzone; 4-hydroxyphenyl benzyl ether; hydroquinone monobenzyl ether
CAS：103-16-2

Result：
ID: 20A2089
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, AS, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance contains oxygen (but not chlorine) which is chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Classification not possible - - - - No data of the substance itself are available, and it cannot be classified.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - Researchers referred to many cases of dermatitis and leukoderma that were caused by skin contact with rubber that contained this substance as an antioxidant. Researchers reported a 13% incidence of contact dermatitis cases where this compound has been used for depigmentation purposes (PATTY (5th, 2001)). However, since such details as possibility as the agent, signs and their levels, and frequency or period of exposure are unknown, the substance cannot be classified. As relevant information, in a test in which it was applied to the skin of guinea pigs for 48 hours (a standard Draize test), the substance was evaluated to be mildly irritating (RTECS (2004)).
3 Serious eye damage/eye irritation Classification not possible - - - - It is rated Xi; R36 in EU classification (EU-Annex I (accessed August 2008)). However, since no other data are available, the substance cannot be classified.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - It is rated R43 in EU classification (EU-Annex I (accessed August 2008)). Researchers referred to a possibility that, in rubber industry, chemical agents used in preparing rubber including this substance as an antioxidant could sensitize exposed workers. (HSBD (2003)). Researchers applied it to the skin of guinea pigs, and determined that it was nonsensitizing (PATTY (5th, 2001)). Due to the above inconsistent results documented, classification is not possible.
5 Germ cell mutagenicity Classification not possible - - - - No data available.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Substance exposure reported that no toxic changes were observed in guinea pigs ingesting it for one or five months for a total dose of 4.37 g (160 mg/kg/day) or 12 g (80 mg/kg/day); the only change noted was a depigmentation of the hair (PATTY (5th, 2001)). However, since these tests were performed many years ago (in 1952 and 1941) and used guinea pigs, and classification based on these data is doubtful, the substance cannot be classified.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - Classification not possible due to lack of data.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - Classification not possible due to lack of data.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information