GHS Classification Result

Chemical Name:2,2'-(methylimino)diethanol; N-methyldiethanolamine
CAS:105-59-9

Result:
ID: 20A2092
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Its flash point is 136degC (ICSC (J) (2005)).
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Its autoignition point is 265degC (ICSC (J) (2005)).
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Since its LD50 = 4.57 g/kg (PATTY (5th, 2001)) and 4780 mg/kg (DFGOT vol. 9 (1998)) for rats, the substance is classified into "Not classified" in JIS classification (equivalent to Category 5 of UN classification criteria).
1 Acute toxicity (Dermal) Not classified - - - - Based on its LD50 = 5990 (3570 - 10070) mg/kg (DFGOT vol.9 (1998)), > 5990 mg/kg (IUCLID (2000)), ca. 10000 - 11300 mg/kg bw (IUCLID (2000)), 10244 (male) - 11336 (female) mg/kg bw (IUCLID (2000)) for rabbits, the substance was classified into "Not classified" using JIS classification criteria (equivalent to Category 5 of UN classification criteria).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - A datum indicates that, in a test using rabbits, the substance induced "slightly irritation" (DFGOT vol.9 (1998)). Other data show similar results. Thus, the substance was classified into "Not classified" using JIS classification criteria (equivalent to Category 5 of UN classification criteria).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
Since, in the rabbit eye, the substance caused redness, swelling, and clouding of the cornea as well as conjuctival bleeding, and the symptoms had disappeared after eight days (DFGOT vol.9 (1998)), the substance was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - In a guinea pig maximization test, the substance was "not sensitizing" (IUCLID (2000)) and would fall under "Not classified". However, since this is List 2 datum, the substance was classified into "Classification not possible".
5 Germ cell mutagenicity Not classified - - - - Since a mouse bone-marrow micronucleus assay (in vivo mutagenicity test using somatic cells) by i.p. administration yielded negative results (IUCLID (2000), the substance was classified into "Not classified". As relevant information, in vitro mutagenicity tests (Ames tests) yielded negative results (NTP DB (accessed August 2008)) (DFGOT vol.9 (1998)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Its oral administration test to rats during the organogenetic period, doses which brought general toxicities, such as body weight reduction, decrease in diet consumption, reversible reduction in water intake, and increase in kidney weight, to parental rats (females) caused increases of postimplantation death (within 0 days after delivery) and mortality rate (within 0 - 4 days after delivery) in offspring (Teratogenic (12th, 2007)). Based on the results, the substance was determined to be into Category 2.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Documented information indicates that in inhalation toxicity study with rats, no symptoms of toxicity were seen at saturated vapor concentration (DFGOT vol.9 (1998)). However, since LOAEL is not described, and due to lack of data, the substance was classified into "Classification not possible".
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - No data available.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Since its 96h-EC50 = 20 mg/L for algae (Scenedesmus) (IUCLID, 2000), the substance was classified into Category 3.
11 Hazardous to the aquatic environment (Long-term) Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Since its preexisting classification for acute toxicity is Category 3, and it is not rapidly degradable (non-biodegradable, BOD degradability, 22, 0, 0% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 2005)), the substance was classified into Category 3.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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