GHS Classification Result

Chemical Name：2-methylaminoethanol
CAS：109-83-1

Result：
ID: 20A2097
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Its flash point of 74degC (ICSC (J) (1998)) is equivalent to the guidance values of Category 4.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Its autoignition point is 350degC (IUCLID (2000)), which is above 70degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on its rat LD50 = 2.34 g/kg (PATTY (5th, 2001)), the substance was classified into "Not classified" using JIS classification criteria (equivalent to Category 5 in UN classification).
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Five studies provided rabbit LD50 values (IUCLID (2000)), 1006 - 1880 mg/kg, all of which are equivalent to the guidance values of Category 4.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The classification is based on the results of "being corrosive" after application to skin of rabbits for 1 - 4 hours (IUCLID (2000)). As relevant notes, its pH is 13.4 (100 mL/L) (IUCLID (2000)), and it is rated C;R34 in EU classification (EU-Annex 1 (accessed August 2008)).
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		It was rated Grade 9 (Grade scale, 1 - 10) in an eye irritation test using rabbits (PATTY (5th, 2001)), and other data shows it is corrosive to skin (IUCLID (2000)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - A skin sensitization test using guinea pigs (Maximization test) indicated that it may induce allergic contact dermatitis (HSDB (2006)). However, its positive rate was not provided, and it was not concluded to be sensitization-positive.
5 Germ cell mutagenicity Classification not possible - - - - Since there is no available in vivo test data, classification is not possible. As relevant information, results of Ames tests were negative (NTP DB (accessed August 2008)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - In a developmental toxicity test in which rats were exposed via inhalation during the organogenetic period, there were no adverse effects on the development of offspring, including teratogenicity effects, except for increase in skeletal mutation (IUCLID (2000)). However, the test did not provide data on fertility or sexual functions of parental animals, and thus, the substance was classified into "Classification not possible".
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Category 1 (testis) Danger H372: Cause damage to organs through prolonged or repeated exposure (testis) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		By orally exposing rats at 400 mg/kg/day (90-day conversion: approximately 142 mg/kg/day) for 32 days, significant increase of weights of some organs, slight changes in blood test values, and slight histological changes in the liver and the testicles were detected (IUCLID (2000)). After exposure via inhalation at 0.005 - 0.03 mg/L/24h (0.01 - 0.06 mg/L/6h/day) for 90 days, no effect was observed in rats and mice, while in a test in which dogs were exposed via inhalation for 90 days (doses: 0.005, 0.03 mg/L/24h (0.02, 0.12 mg/L/6h/day)), dose-dependent atrophy of the seminiferous tubules and weight reduction of the testicles at the dose of 0.12 mg/L/6h/day were observed, and so were effects on the testicles at the dose equivalent to the guidance value of Category 1 (IUCLID (2000)). Thus, the substance was classified into Category 1 (testis).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Since its 72h-ErC50 = 28.1 mg/L for algae (Scenedesmus) (IUCLID, 2000), the substance was classified into Category 3.
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Its preexisting classification for acute toxicity is Category 3, it is rapidly degradable (BOD degradability, 68%; TOC degradability, 97%; extent of degradation by HPLC, 100% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 2002)) and its potential for bioaccumulation is estimated to be low (LogPow = -0.94 (PHYSPROP Database, 2008)). Thus, the substance was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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