Chemical Name：1,2-dimethoxyethane; ethylene glycol dimethyl ether; EGDME
CAS：110-71-4

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	-	-	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 2		Danger	H225: Highly flammable liquid and vapour	P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ...	Its flash point is lower than 23degC (-2degC (HSDB (2002))), and its initial boiling point is above 35degC (85degC (HODOC (3rd, 1997))).
7	Flammable solid	Not applicable	-	-	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	-	-	-	-	Its autoignition point is 200degC (Hommel (1996)), which is above 70degC.
10	Pyrophoric solids	Not applicable	-	-	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	-	-	-	-	The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14	Oxidizing solids	Not applicable	-	-	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule
16	Corrosive to metals	Classification not possible	-	-	-	-	No data available.

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Based on its mouse LD50 value of 2525 mg/kg (PATTY (5th, 2001)), the substance was classified into "Not classified" using JIS classification criteria (Category 5 in UN classification).
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available.
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	No data available.
3	Serious eye damage/eye irritation	Classification not possible	-	-	-	-	No data available.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	No data available.
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	Because it lacks in vivo test data and in vitro mutagenicity test results with multiple indexes, classification is not possible. As relevant information, the substance was negative in Ames tests (in vitro mutagenicity tests) (ECETOC TR.64 (1995), TR.95 vol. 2 (2005)).
6	Carcinogenicity	Classification not possible	-	-	-	-	No data available.
7	Reproductive toxicity	Category 1B		Danger	H360: May damage fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	In oral administration tests to mice during the organogenetic period, doses that were not toxic to maternal animals caused such signs as limb deformities and exencephaly in offspring (ECETOC TR.17 (1985), TR.64 (1995), TR.95 vol. 2 (2005), PATTY (5th, 2001)). In addition, it is rated R60 and R61 in EU classification and classified into Reproductive toxicity category 2 (equivalent to GHS Category 1B). Thus, the substance was classified into Category 1B.
8	Specific target organ toxicity - Single exposure	Category 3 （Narcotic effects）		Warning	H336: May cause drowsiness or dizziness (narcotic effects)	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ...	Since the doses being over the upper limit of the guidance value for Category 2 caused significant reduction in avoidance response, not in escape response (PATTY (5th, 2001)), the substance was classified into Category 3 (narcotic effects).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	In a 2-week inhalation exposure test using rats, doses of 3.75 mg/L and 7.5 mg/L (4 hours/day, 5 days/week), which keep animals alive and are within guidance values for Category 2, caused a reversible significant decrease in the avoidance response (PATTY (5th, 2001)). Since half of the animals died at the dose of 30 mg/L (4 hours/day, 5 days/week) (equivalent to Not classified), the substance is suspected to affect the central nervous system. However, the substance was classified into "Classification not possible" due to a lack of data. Because its saturated vapour pressure concentration (20degC) is 63200 ppmV (237 mg/L), its physicochemical state was considered to be vaporous.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.