GHS Classification Result

Chemical Name：hexan-1-ol
CAS：111-27-3

Result：
ID: 20A2100
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		If the flash point is 60degC or lower, the substance fits in Category 3, and if above 60degC, fits in Category 4. The flash points are 58.4degC (Closed Cup, HSDB (2006)), and 63degC (Closed Cup, Merck (14th, 2006), HSDB (2006)), and the compound fits in UNRTDG Class 3, Packing group III. Thus, the substance was classified into Category 3 based on the rating.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Since its autoignition points are 290 - 304degC (HSDB (2006), ICSC (J) (2002), NFPA (13th, 2006)), the substance was classified into "Not classified".
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - In rat LD50 studies, a study provided a value that was equivalent to the guidance value of Category 4 (LD50 = 1800 mg/kg (male), 720 mg/kg (female) (DFGOT vol. 9, (1998))), and four studies provided values that were equivalent to the guidance values of "Not classified" (LD50 = 4000 mg/kg, 4590 mg/kg, 4870 mg/kg, 7080 mg/kg (DFGOT vol. 9, (1998))). Thus, the substance was classified into "Not classified".
1 Acute toxicity （Dermal） Not classified - - - - Based on its rabbit LD50 value of 2538 mg/kg (DFGOT vol. 9, 1998; PATTY 5th, 2001), the substance was classified into "Not classified" using JIS classification criteria (Category 5 in UN classification).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - A single 8-hour exposure to air practically saturated with the substance at 20degC (saturated vapour pressure concentration at 20degC (approximately 5.6 mg/L)) (4-hour conversion, approximately 8 mg/L) was "not lethal" for rats (DFGOT vol. 9, 1998). However, the results provide insufficient data, and thus, classification is not possible.
1 Acute toxicity （Inhalation: Dusts and mists） Not classified - - - - In a 1-hour inhalation test using rats, the LC50 was more than 21 mg/L (4-hour conversion LC50 > 10.5 mg/L, IUCLID 2000). Thus, the substance was classified into "Not classified".
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		In a human patch test, the substance was applied to the skin for up to four hours. The irritation response was significantly lower than that of the positive control (PATTY (5th, 2001)). In a rabbit test compliant with OECD TG 404, the substance was indicated to be "moderately irritating" (IUCLID (2000)). With unknown doses and administration periods, the substance caused "moderate irritation" (DFGOT vol. 9 (1998) and "erythema and swelling like a first degree burn" (DFGOT vol. 9 (1998). Based on these results, the substance was classified into Category 2.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		In a rabbit test, the averaged score values 72 hours after application were 2 for corneal clouding, 1.25 for iritis, 2.5 for conjunctival redness, and 2.5 for chemosis, but these signs completely subsided within 21 days after application (ECETOC TR. 48 (1998)). In a rabbit test (OECD TG 405), the substance was considered to be moderately irritating (IUCLID (2000)), and in another rabbit test, a 5% solution caused severe eye erosion while a 1% solution still caused severe irritation (DFGOT vol. 9, 1998). Based on these results, the substance was classified into Category 2A.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Not classified - - - - Based on the description that no sensitization was observed in a human patch test or an allergic test in guinea pigs (according to the method of Magnusson and Kligman) (DFGOT vol. 9, 1998), the substance was classified into "Not classified".
5 Germ cell mutagenicity Classification not possible - - - - Because in vivo mutagenicity test data on this substance are lacking (DFGOT vol. 2 (1998), IUCLID (2000)), the substance was classified into "Classification not possible".
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - As for its developmental toxicity, oral administration to rats during the organogenetic period caused clinical signs and decreased body weight gains in parental animals, but no embryotoxic or teratogenic effects were observed (PATTY 5th, 2001). However, the study did not provide data on sexual functions or fertility of parental animals, and thus, the substance was classified into "Classification not possible".
8 Specific target organ toxicity - Single exposure Classification not possible - - - - It is documented that rats were given the substance of 440 mg/kg (for males) and 90 mg/kg (for females) by gavage, and the renal cortex was hyperaemic with cloudy swelling (DFGOT vol. 9, 1998). However, this report lacks detailed data, and the substance was classified into "Classification not possible". As relevant information, a mixture containing this substance was used in an inhalation test using rats, mice, and guinea pigs, and in a skin test using rabbits. In the inhalation test, the mixture containing the substance was associated with respiratory irritation. However, the purity of the substance was as low as 44% (44% 1-hexanol, 53% methyl-1-pentanol), and the finding was not used for classification.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In a test in which rats were fed a diet containing the substance for three weeks (PATTY 5th (2001)), a dose of 330 mg/kg bw (converted for 90 days), that was over the guidance range, showed no effect other than minimal changes such as the blood lipid level. In addition, in a test in which rats were fed a diet containing the substance for 13 weeks (IUCLID (2000)), doses that were over the guidance range resulted in NOAEL of 250 mg/kg bw and LOAEL of 500 mg/kg bw. These doses would be equivalent to the guidance values of "Not classified" (oral). However, since no data of other administration routes is available, the substance was classified into "Classification not possible".
10 Aspiration hazard Classification not possible - - - - It is documented that aspiration of 0.2 mL of the substance caused deaths in 10 out of 10 rats, and that the deaths were instantaneous due to respiratory arrest (PATTY 5th, 2001; IUCLID, 2000). However, since the description is old and it does not provide sufficient information for classifying the substance into "Not classified" (Category 2 in UN classification), the substance was classified into "Classification not possible".

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Since its 96 h-LC50 = 97.7 mg/L for fish (fathead minnow) (AQUIRE, 2008), the substance was classified into Category 3.
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Since its preexisting classification for acute toxicity is Category 3 and it lacks reliable rapid degradability data, the substance was classified into Category 3.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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