GHS Classification Result

Chemical Name:2-hexyloxyethanol; ethylene glycol monohexyl ether; n-hexylglycol
CAS:112-25-4

Result:
ID: 20A2101
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Since its flash point is 81.7degC (c.c.) (ICSC (2004), ICSC (J) (2004)), the substance was classified into Category 4 based on GHS classification criteria.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Its autoignition point is 220degC (ICSC (2004), ICSC (J) (2004)). According to classification guidelines, substances with an autoignition point of 70degC or higher are classified into "Not classified".
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on its LD50 = 739, and 1480 mg/kg bw in tests using rats (SIDS (accessed in August 2008)), the substance was classified into Category 4.
1 Acute toxicity (Dermal) Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on its LD50 = 721, and 792 mg/kg bw in tests using rabbits (SIDS (accessed in August 2008)), the substance was classified into Category 3.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - In an inhalation exposure test using rats, since its LC50 (4h) > 0.5 mg/L (conversion > 84 ppm) (IUCLID, 2000) was less than 90% of the saturated vapour pressure concentration (129 ppm), the substance should be a "vapour with almost no included mists." However, the result provides insufficient data for classifying the substance into which of the categories from "Category 2" to "Not Classified", and thus, it was classified into "Classification not possible".
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
In a 4h exposure test using rabbits (SIDS (accessed in August 2008)), three rabbits out of six showed necrosis between days 1 and 7. Therefore the substance was classified into Category 1. It is rated R34 in the EU classification (equivalent to Category 1B or 1C) (EU-Annex 1 (accessed in August 2008)).
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
Based on descriptions that in a test using rabbit eyes, reversible chemosis (Draize scores of 2 to 3), iritis (Draize scores of 1), and opacity of the cornea (Draize scores of 1) were seen, and no injury was observed in any of the animals after seven days (SIDS (accessed in August 2008)), the substance should be classified into Category 2B. However, since it is a skin corrosive, the substance was classified into Category 1.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Not classified - - - - Since it showed negative results in an in vivo micronucleus test (SIDS (accessed in August 2008)), the substance was classified into "Not classified".
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - In a rat teratogenicity test (inhalation exposure, on gestational days 6?15, doses of 20.8, 41.4, and 79.2 ppm), no abnormality such as the number of corpora lutea or loss of implantation, fetal sex ratio, malformations or variations by category (external, visceral, or skeletal) was found. The incidence of fetal atelectasis (a variation) increased in the low-dose group, but not in the intermediate- or high-dose groups (SIDS (accessed in August 2008)). In a rabbit teratogenicity test (inhalation exposure, on gestational days 6?18, doses of 20.8, 41.4, and 79.2 ppm), there was no abnormality in the numbers of pregnancies or implantations, but there were two resorptions (resorbed) in the low-dose group and one in the high-dose group. Based on the above results, since fetal atelectasis in rats and resorption in rabbits were not dose-dependent, and parental fertilities have not been tested, the substance was classified into "Classification not possible".
8 Specific target organ toxicity - Single exposure Category 2 (respiratory system) Warning H371: May cause damage to organs (respiratory system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
Since it has been documented that in an oral test using rats, signs of mucosal irritation were presented, indicating potential lung damage by aspiration (ECETOC, TR95, vol.2, 2005), the substance was classified into Category 2 (respiratory organ).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - After a 13-week inhalation test using rats (doses of 20, 41, and 71 ppm) (SIDS (accessed in August 2008)), in the high-dose group (conversion, 0.42 mg/L), females showed changes in liver enzymes (decreases in AST, ALT, and SDH, increase in ALP), and increases in relative kidney weight (0.76 vs 0.69 (control), p < 0.01) and relative liver weight (significant, p < 0.01). Males showed no abnormalities in liver enzymes, but increases in relative kidney weight (0.69 vs 0.64 (control), p < 0.01) and relative liver weight. These results suggested effects of inhalation exposure on the liver and the kidneys, but it is described that the significance of the changes in liver enzymes is unclear, since decreases were observed in 3/4 of the enzymes and an increase was observed in only one of the enzyme, and no histopathological lesions were found in the liver or the kidneys, and therefore, the substance was classified into "Classification not possible". As relevant information, it is described that the increase in relative kidney weight in males in the intermediate-dose group was not biologically significant, and that the increase in relative liver weight in females appears to be adaptive.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - Since its 48h-EC50 = 145 mg/L for crustaceans (Daphnia magna) (SIDS, 2004), the substance was classified into "Not classified".
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since the substance is water soluble (water solubility, 9900 mg/L (SRC, 2005)) and its preexisting classification for acute toxicity is "Not classified", it was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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